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    Chinese Journal of Child Health Care    2024, 32 (4): 349-358.   DOI: 10.11852/zgetbjzz2024-0279
    Abstract2311)      PDF (1552KB)(2788)      
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    Assessment and management of depression in adolescents
    LUO Xuerong, TANG Xinhai, SHEN Yanmei
    Chinese Journal of Child Health Care    2024, 32 (7): 700-703.   DOI: 10.11852/zgetbjzz2024-0694
    Abstract1908)      PDF (550KB)(105)      
    Adolescent depression is a serious public health issue that affects the mental health of millions of adolescents nationwide. This articleoutlines the current situation of adolescent depression, the challenges in diagnosis, and then introduces the assessment process, including collecting medical history, physical examination, using scales and diagnostic tools for assessment, as well as assessing comorbidities and suicide risk. Treatment should be based on individual′s characteristics and needs, selecting appropriate treatment methods, including psychotherapy, medication, and hospitalization when necessary, inpatient treatment. Psychotherapeutic methods include cognitive-behavioral therapy and interpersonal therapy, while medication treatment requires careful selection of appropriate antidepressants and close monitoring of possible side effects.
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    Children's social and personality development and the influence of family upbringing
    DING Yanhua, FEI Zhixing
    Chinese Journal of Child Health Care    2024, 32 (7): 704-708.   DOI: 10.11852/zgetbjzz2024-0693
    Abstract1604)      PDF (743KB)(111)      
    Children's social and personality development are influenced by the long-term interaction of nature and nurture. Family is the primary source of influence on Children's early social and personality development. The appropriate combination of two significant dimensions of family upbringing, acceptance/responsiveness and demandingness/control, is stably related to Children's good social and personality development outcomes.
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    Correlation of early parent-child interaction and sleep time with emotional and behavioral problems in preschool children
    CAO Hui, YAN Shuangqin, GAO Guopeng, WANG Sumei, XIE Liangliang, JIANG Liu, XIE Fangfang, TAO Fangbiao
    Chinese Journal of Child Health Care    2024, 32 (7): 785-789.   DOI: 10.11852/zgetbjzz2023-1390
    Abstract1539)      PDF (546KB)(76)      
    Objective To explore the correlation of early parent-child interaction and sleep time with emotional and behavioral problems in preschool children,in order to provide evidence for promoting the development of Children's mental health. Methods Children aged 3 years who underwent normal physical examination in Ma′anshan Maternal and Child Health Hospital from January 2019 to May 2020 were selected to collect information about parent-child interaction and sleep status through questionnaires.Emotional and behavioral problems were investigated in patients who came to the clinic for continued medical examination during the period of 5 to 7 years of age.A total of 399 valid questionnaires were collected.Pearson χ 2 test and Logistic regression were used to analyze the data. Results After adjusting for demographic information,lower score of early parent-child interaction was a risk factor for peer interaction( OR=2.30,95% CI:1.16 - 4.58) and emotional and behavioral problems( OR=2.76,95% CI:1.54 - 4.95).Children with total sleep time <12h/d were more likely to have peer interaction ( OR=2.26,95% CI:1.22 - 4.20) and emotional and behavioral problems ( OR=1.73,95% CI:1.04 - 2.87).Combined effect showed that children with lower score of early parent-child interaction and sleep time <12h/d had a higher risk of developing peer interaction ( OR=5.30,95% CI:1.53 - 18.27),emotional and behavioral abnormalities ( OR=6.23,95% CI:2.15 - 18.45). Conclusions Poor quality of early parent-child interaction and insufficient sleep time have adverse effects on preschool Children's emotional and behavioral problems,which should be given more attention.
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    Identification and treatment of nonsuicidal self-injury in adolescents
    CHA Caihui, OU Wanxing
    Chinese Journal of Child Health Care    2024, 32 (7): 697-699.   DOI: 10.11852/zgetbjzz2024-0644
    Abstract1512)      PDF (561KB)(110)      
    Nonsuicidal self-injury, not aimed at suicide, is more common in adolescents and has various self-injury behaviors. Now there is a lack of effective prevention and treatment methods. The types of self-injury behaviors, risk factors, and the psychological needs of patients and treatment strategies are summarized in this review.
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    Association between body satisfaction and depressive symptoms in early adolescents
    YOU Lijun, ZUO Xiayun, YU Chunyan, LIAN Qiguo, FANG Yuhang, TU Xiaowen, LOU Chaohua
    Chinese Journal of Child Health Care    2024, 32 (7): 713-717.   DOI: 10.11852/zgetbjzz2023-1131
    Abstract1447)      PDF (640KB)(73)      
    Objective To explore the association between body satisfaction and depressive symptoms among early adolescents in Shanghai, in order to provide evidence for the promotion of mental health among adolescents. Methods A total of 1 704 students from grade 6 to 8 in 3 junior middle schools in Shanghai were recruited into this study from November to December in 2017 by stratified cluster sampling method.Data were collected by anonymous self-administered electronic questionnaire, and the body satisfaction scale and depressive symptom scale were used to collect the body satisfaction and depressive symptoms of the subjects. Results The average score of body satisfaction was 23.03±4.68, ranging from 7 to 35.There were significant differences in body satisfaction score among adolescents with different genders, education level of primary caregivers and perceived academic performance ( P<0.05).The average score of depressive symptoms in adolescents was 15.94±5.05, ranging from 6 to 30.There were statistically significant differences in depressive symptoms score among adolescents with different genders, age, whether they were the only child, whether they were separated from their parents and perceived academic performance ( P<0.05).Multivariate linear regression analysis indicated that body satisfaction was negatively correlated with scores of depressive symptoms and the association was statistically significant ( β=-0.35, P<0.05).There was significant difference in the associations between body satisfaction and depressive symptom scores in adolescents of different genders (boys: β=-0.30, girls: β=-0.40), and the difference was statistically significant ( P<0.05). Conclusion There is a significant negative association between body satisfaction and depressive symptoms in early adolescence, improving body satisfaction may help reduce depressive mood in adolescents.
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    Effects of lifestyle behaviors on psychological and behavioral problems among school-age children
    LI Wenjing, MA Qianqian, CHEN Chen, LI Jun, WU Dandan, ZENG Lingxia
    Chinese Journal of Child Health Care    2024, 32 (7): 718-724.   DOI: 10.11852/zgetbjzz2023-1250
    Abstract1404)      PDF (825KB)(78)      
    Objective To explore the association between lifestyle and psycho-behavioral problems in school-age children,in order to provide scientific basis for the prevention of Children's behavioral problems. Methods Using stratified whole-cluster sampling,1 200 school-age children aged 9 - 13 years in Xi'an were selected for a paper questionnaire survey in May 2023.Their behavioral and emotional problems in the past six months were evaluated using the Youth Self-Report (YSR).Information on basic family situation and lifestyles was collected through self-designed questionnaires on the demographic characteristics of their families and their lifestyles.The correlation between Children's lifestyles and psycho-behavioral problems was explored and validated using the χ 2 test and binary logistic Logistic regression model. Results The detection rate of psychological and behavioral problems in school-age children in this study was 22.4% (252/1 127).Thinking problems were most prominent among the factors (14.8%),followed by social problems (10.6%).Multivariate Logistic regression analysis showed that picking eating ( OR=4.595,95% CI:1.593 - 13.249),doing homework >3h/d ( OR=3.644,95% CI:1.640 - 8.096),and screen time >2h/d ( OR=2.691,95% CI:1.311 - 5.527) or >3h/d ( OR=3.542,95% CI:1.848 - 6.789),and never doing housework ( OR=7.477,95% CI:1.372 - 40.733) were risk factors for psychological and behavioral problems in school-age children.Occasional ( OR=0.530,95% CI:0.315 - 0.892) or frequent ( OR=0.447,95% CI:0.266 - 0.753) participation in physical activity,visiting a healthcare worker ( OR=0.205,95% CI:0.115 - 0.365) or a doctor ( OR=0.341,95% CI:0.150 - 0.772)in sick,having few illnesses in infancy and early childhood ( OR=0.435,95% CI:0.219 - 0.866),and having 4 or more good friends ( OR=0.270,95% CI:0.093 - 0.783) reduced the risk of developing psychological and behavioral problems in school-age children. Conclusions Lifestyle of school-age children is closely related to psycho-behavioral problems.Paying attention to Children's thinking and social problems,advocating scientific diet,active exercise,encouraging children to participate in household chores appropriately,reducing video screen time,and controlling undesirable habits will help improve their behavioral problems.
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    Impact of family harm on the development of Children's early mental cognition and social adaptability
    LIU Sijia, HUANG Chuican, FAN Lichun
    Chinese Journal of Child Health Care    2024, 32 (7): 757-761.   DOI: 10.11852/zgetbjzz2023-0916
    Abstract1362)      PDF (601KB)(56)      
    Family serves as the primary context for a child′s daily life,with family harm emerging as a significant factor influencing early psychological cognitive and social adaptability development in children and adoleacents.This issue has become a serious public concern due to its potential to jeopardize the holistic well-being of children,garnering attention from scholars globally.Despite this,there remains a gap in the domestic literature regarding the comprehensive exploration of the association of family harm with the developmental aspects of early psychological cognitive and social adaptability abilities in children.The article provides a summary and review of the theories,main content,and impact on the cognitive and social adaptive development of children and adolescents regarding family harm,aiming to enhance scholars′understanding of family harm in our country and collectively promote the healthy growth of children and adolescents.
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    Expert consensus on the construction of traditional Chinese medicine child health care specialty
    Child Health Care Branch of Chinese Preventive Medicine
    Chinese Journal of Child Health Care    2024, 32 (5): 465-470.   DOI: 10.11852/zgetbjzz2023-1318
    Abstract1230)      PDF (1044KB)(322)      
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    Communication disorders in children with autism spectrum disorder from speech language pathology perspective
    YANG Feng
    Chinese Journal of Child Health Care    2024, 32 (3): 233-236.   DOI: 10.11852/zgetbjzz2024-0114
    Abstract1128)      PDF (722KB)(317)      
    Children with autism spectrum disorder (ASD) face varying degrees of difficulties in communication, language, and social interactions.This article analyzes the basic communication abilities, language development characteristics, and social pragmatic features of ASD children from the perspective of speech pathology, introduces corresponding assessment tools and proposes intervention strategies based on the International Classification of Functioning, Disability, and Health (ICF).Meanwhile, this article emphasizes the adoption of a comprehensive intervention model that involves medical, family, and school components to enhance the communication, language, and social skills of this group comprehensively, with the aim of effectively improving their overall quality of life.
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    Early screening and intervention of children with developmental coordination disorder
    LIU Zhenhuan
    Chinese Journal of Child Health Care    2024, 32 (5): 475-479.   DOI: 10.11852/zgetbjzz2024-0280
    Abstract1059)      PDF (669KB)(162)      
    Developmental coordination disorder (DCD) is a neurodevelopmental disorder with high incidence, low diagnosis rate and early onset of symptoms, which hinders thedevelopment ofphysical and mental health in children.Early identification and intervention of DCD can help reduce the lifelong adverse effects of the disease.However,general public in China still lacks awareness of this condition,and healthcare workers do not pay enough attention to the early screening and intervention of DCD.This paper summarizes the clinical characteristics, early screening and diagnosis of DCD, and expounds the clinical treatment of DCD from the two aspects of western and Chinese medicine intervention, and proposes the intervention treatment of integrated Chinese and western medicine for the first time, hoping to promote the development of early screening work, provide a new method for the research and development of DCD intervention in China, and improve the effectiveness of treatment.
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    Correlation between deformational plagiocephaly and/or brachycephaly and motor developmental delay in infants
    XU Wei, HE Chengchuan, CHEN Xuejiao, HUANG Mingshou, SONG Guan
    Chinese Journal of Child Health Care    2024, 32 (5): 480-483.   DOI: 10.11852/zgetbjzz2023-0665
    Abstract970)      PDF (592KB)(123)      
    Objective To analyze the correlation between deformational plagiocephaly and/or brachycephaly (DPB) and motor developmental delay in infants, so as to provide theoretical basis for early motor development screening and intervention in DPB infants. Methods A total of 7 826 children aged 6 - 12 months who visited Mianyang Maternal & Child Health Care Hospital from January 2021 to December 2022 were inlcuded in this study. DPB infants were selected as the study subjects, and the prevalence rate was analyzed.2 761 DPB infants were divided into mild, moderate, and severe DPB groups, and 1 900 normal children were included as the control group. Peabody Developmental Motor Scale-2 (PDMS-2) was used to evaluate the levels of gross and fine motor development in children in each case group and control group. Univariate analysis and LSD- t test were used to analyze the differences in gross motor quotient (GMQ) and fine motor quotient (FMQ) of children in each group. χ2 test was used to analyze the rate of motor developmental delay in children in each group. Results The prevalence rate ofDPB was 35.47%. There were statistically significant differences in GMQ and FMQ among the mild DPB group, moderate DPB group, severe DPB group, and control group ( F=171.271, 194.877, P<0.05). Further statistical comparison showed that there was no statistically significant difference in GMQ and FMQ between mild DPB group and control group ( P>0.05). The GMQ and FMQ of the moderate and severe DPB groups were significantly lower than those of the control group ( P<0.05). There was no statistically significant difference in the rate of developmental delay in gross and fine motor development between each case group and the control group ( χ2=7.478 , 5.777 , P>0.05). Conclusions The prevalence of DPB in Mianyang area is relatively high, and DPB do not increase the probability of motor development delay. However, infants with moderate to severe DPB have significantly lower levels of motor development compared to healthy infants. It is recommended to screen infants with DPB as soon as possible, and conduct motor development screening and exercise promotion for infants with moderate to severe DPB.
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    Establishment of joint intervention in hospital-school-home model for developmental coordination disorder
    JIA Feiyong
    Chinese Journal of Child Health Care    2024, 32 (5): 471-474.   DOI: 10.11852/zgetbjzz2024-0281
    Abstract951)      PDF (472KB)(91)      
    Developmental coordination disorder (DCD) is a kind of movement disorder with lifelong adverse effects.According to motor learning and motor control theories, improving movement should be combined with individual, task and environment of children.Interventions for DCD children should not only be limited to the hospital, a more reasonable model should include the hospital, school and home three scenarios of combined treatment.This article expounds the importance and specific content of this intervention model, so as to provide reference for the healthy development of children with DCD.
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    Establishment of early learning opportunities in nurturing care
    TONG Meiling
    Chinese Journal of Child Health Care    2024, 32 (2): 117-121.   DOI: 10.11852/zgetbjzz2024-0044
    Abstract778)      PDF (753KB)(198)      
    Both UNICEF and WHO mention that nurturing care is the most direct and effective approach to promoting early childhood development. Nurturing care emphasizes the importance of caregivers creating a suitable nurturing environment for the early development of children to promote their health and potential. The provision of early learning opportunities is an important aspect of creating a high-quality nurturing environment. This review focuses on the importance of establishing early learning opportunities, the methods of establishing early learning environments, implementing supportive strategies, and employing relevant evaluation methods, in order to provide reference and support for the establishment of early learning opportunities in nurturing care.
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    Chinese Journal of Child Health Care    2024, 32 (9): 929-933.   DOI: 10.11852/zgetbjzz2024-0988
    Abstract733)      PDF (763KB)(132)      
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    Nested case-control study on the risk factors and interaction analysis of positive screening for infant motor development
    HU Yue, BAO Zheng, WANG Ronghuan
    Chinese Journal of Child Health Care    2024, 32 (5): 502-506.   DOI: 10.11852/zgetbjzz2023-0555
    Abstract731)      PDF (1202KB)(70)      
    Objective To identify the influencing factors of infant motor development,and to explore the potential interactive factors, so as to provide scientific basis for early prediction and targeted prevention of infant motor developmental delay. Methods Data of infants receiving "0~1 motor development screening" at 21 community health service centers in Tongzhou District, from January 1st, 2020 to August 31st, 2021 were collected through the Beijing Maternal and Child Information System.Using the method of nested case-control study, 416 infants with positive screening results were selected as case group, 416 infants with negative screening result were selected into the control group by 1∶1 case-control matching of screening age.Chi-square test, Logistic regression analysis, and Exhaustive CHAID decision tree model were used to explore the influencing factors of infant motor development, the interaction effect was investigated by using the additive and multiplicative interaction models. Results Multivariate Logistic analysis showed that birth weight<2 500g ( OR=3.28), cesarean section ( OR=1.63), outdoor activity≤ 1h/d ( OR=3.07), and no supplementation of vitamin D ( OR=2.68) were risk factors for positive screening results of infant motor development ( P<0.01).The Exhaustive CHAID decision tree showed that low birth weight was the primary risk factor for infant with positive screening results, followed by outdoor activity, vitamin D supplementation and delivery.The interaction analysis showed that there was a multiplicative interaction ( OR=13.76, 95% CI:1.20 - 158.08) and an additive interaction ( RERI=10.22, 95% CI:5.05 - 15.38) between non supplementation of vitamin D and low birth weight on infant motor development with positive screening results. Conclusions Attention should be paid to the early motor development of infants with low birth weight and those born by cesarean section, with emphasis on the dosage of vitamin D supplementation and outdoor activity duration.Moreover, the early screening and hierarchical management of infant motor development should also be strengthened.
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    Practice and prospects of integrating nurturing care and family interventions for autism spectrum disorder
    LI Tingyu, WEI Qiuhong, LI Yan, WEI Hua, DAI Ying, CHEN Li
    Chinese Journal of Child Health Care    2024, 32 (9): 937-940.   DOI: 10.11852/zgetbjzz2024-0682
    Abstract627)      PDF (636KB)(108)      
    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with increasing prevalence, posing significant challenges on families and society. As the number of children with mild symptoms and normal intellectual abilities rises, new opportunities for rehabilitation and intervention have emerged. In this context, it is crucial to explore ways to enhance parental caregiving skills to promote the recovery of ASD children. This editorial introduced a novel model that integrated caregiving into family-based interventions, particularly suited for early intervention in economically underdeveloped regions of China for children with ASD. Additionally, it provided valuable insights for resource-limited developing regions.
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    Relationship between responsive caregiving for infants and young children and parenting confidence among caregivers
    LIU Panting, ZHANG Lei, HONG Qin, CHI Xia, TONG Meiling, QIAN Jun
    Chinese Journal of Child Health Care    2024, 32 (2): 133-137.   DOI: 10.11852/zgetbjzz2023-0689
    Abstract565)      PDF (501KB)(90)      
    Objective To investigate the current state of infant responsive caregiving and to analyze its correlation with caregiver parenting confidence, in order to provide theoretical basis for improving the level of responsive care for infants and young children. Methods A cross-sectional survey was conducted from October 2022 to February 2023 to select 1 028 infants and young children under 3 years old who underwent health examinations in the Department of Child Healthcare. Participants completed a general data questionnaire, the Karitane Parenting Confidence Scale, and the Infant Responsive Caregiving Scale. Hierarchical multiple linear regression analysis was used to investigate the related influencing factors of infant responsive care and to analyze the relationship between caregiver parenting confidence and responsive caregiving. Results The level of responsive caregiving was found to be associated with various factors such as infant age(χ 2=21.196), mode of pregnancy(Z=-2.072), history of pregnancy protection during pregnancy(Z=-4.713), history of pregnancy complications (Z=-4.504), gestational week at birth(χ 2=41.358), small for term infants(Z=-3.497), neonatal intracranial hemorrhage(Z=-5.425), neonatal hyperbilirubinemia(Z=-2.184), maternal education level(χ 2=9.419), family income(χ 2=11.211) as well as type of family (χ 2=15.360)(P < 0.05). Additionally, a significant correlation was observed between parenting confidence and responsive caregiving(r=0.421, P<0.001). Hierarchical multiple linear regression analysis revealed that caregiver parenting confidence had a significant positive effect on the level of responsive caregiving (B=0.623, P<0.05), even after controlling for the effect of demographic factors. Conclusion The level of infant responsive caregiving is influenced by caregiver parenting confidence, and increasing caregiver parenting confidence can effectively improve the quality of responsive caregiving for infants and young children.
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    Assessment and influencing factors of bone health in children and adolescents
    WANG Ai, ZHOU Bingqian, YU Jian, CAO Hong
    Chinese Journal of Child Health Care    2024, 32 (9): 980-983.   DOI: 10.11852/zgetbjzz2023-0932
    Abstract538)      PDF (728KB)(87)      
    Osteoporosis begins in childhood, and the accumulation of bone strength and bone mass during growth and development is essential for the prevention of osteoporosis and fragility fractures. Dual energy X-ray absorptiometry, as the preferred bone mass assessment technique for children and adolescents with osteoporosis, can be combined with clinically significant fractures to make a diagnosis of osteoporosis. Peak bone mass and bone mineral density(BMD) can be increased through intervention of factors such as physical activity, nutritional intake, medication, and lifestyle. Hospitals, families, schools, the internet and other parties should join forces to strengthen the popularization of osteoporosis knowledge and promote the disease cognition and bone protection behavior of children and adolescents. This article reviews the definition, assessment tools and influencing factors of osteoporosis in children and adolescents, so as to provide reference for promoting the prevention and intervention of osteoporosis in children and adolescents.
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    Dietary therapy and challenges for familial chylomicronemia syndrome
    WANG Qiao, GONG Chunxiu
    Chinese Journal of Child Health Care    2024, 32 (9): 934-936.   DOI: 10.11852/zgetbjzz2024-0894
    Abstract514)      PDF (571KB)(57)      
    Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive genetic disorder caused by variations in the LPL gene, which codes for lipoprotein lipase, or in genes coding for proteins that regulate lipoprotein lipase activity. Markedly elevated plasma triglyceride (TG) levels (typically >10mmol/L), along with the resulting rash yellow tumor, retinal hyperlipidemia, splenomegaly, recurrent abdominal pain, and pancreatitis attacks are the main clinical manifestations of FCS. Among them, pancreatitis is the primary life-threatening complication and the main cause of reduced quality of life, with its incidence and severity clearly related to plasma TG levels. Conventional lipid-lowering drugs are typically ineffective in FCS patients. Currently, a long-term strict very low-fat diet is the main treatment for this disease. This usually involves reducing dietary fat intake to 10% - 15% of total energy needs while ensuring adequate intake of essential fatty acids. Dietary management can rapidly lower plasma TG levels and effectively prevent complications related to hypertriglyceridemia. However, maintaining and adhering to such a strict very low-fat diet regimen over the long term remains challenging. Surveys have shown that a large part of patients face psychological and social support issues. Therefore, the treatment of FCS requires interdisciplinary collaboration in pharmacology, genetics, nutrition, psychology, and other fields.
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    Factors associated with nursery care institution attendance for children aged 0 - 3 years old and the basic characteristics of nursery care institutions that children were enrolled in
    DONG Wenhong, YAO Xinmeng, XU Xin, LYU Lina, WANG Shasha, ZHENG Shuangshuang, WANG Lei, ZHU Bingquan, SHAO Jie
    Chinese Journal of Child Health Care    2024, 32 (2): 122-126.   DOI: 10.11852/zgetbjzz2023-0670
    Abstract463)      PDF (661KB)(123)      
    Objective To understand factors associated with children's attendance at nursery care institutions (NCIs) and the basic characteristics of the NCIs children were enrolled in, so as to provide scientific evidence for policymakers. Methods During November 2020 and January 2021, parents who visited the Department of Child Health Care in six selected maternal and children's hospitals, as well as nearby NCIs in Zhejiang were invited to finish an online questionnaire. Information such as children's sociodemographic characteristics, parents' knowledge, attitude and practice regarding nursery and feeding, etc. were collected. A total of 1 756 questionnaires were collected. Results Compared to children who were not in NCIs, children enrolled in NCIs were older (94.4% of children ≥24 months vs. 30.1%, χ 2=835.27), more likely to be from the local area (87.2% vs. 81.4%, χ 2=12.25), more likely to have parents with a college degree (mother:83.6% vs. 74.2%, χ 2=35.29; father:79.9% vs. 70.0%, χ 2=27.01), had a higher prevalence of family annual income >200 000 CNY (49.5% vs. 28.2%, χ 2=110.49), and were less likely to have their grandparents available to take care of them (16.7% vs. 26.8%, χ 2=31.4)The difference all have great significant.(P<0.05). In a multivariate Logistic regression model, the older the child, the more likely they were to attend an NCI (for children aged 6 - 23 months, OR=6.70; for children aged 24 - 35 months, OR=134.03; and for children aged 36 - 42 months, OR=699.33; P<0.05). Family annual income was positively associated with children's attendance at NCIs (for those earning 100 000 - 200 000 CNY/year, OR=1.63; for those earning 200 000 - 500 000 CNY/year, OR=2.96; and for those earning >500 000 CNY/year, OR=4.62, P<0.05). Conversely, the higher the level of grandparent involvement in daily care, the lower the attendance at NCIs (for children cared for by both parents and grandparents, OR=0.57; for those primarily cared for by grandparents, OR=0.26, P<0.05). For children who used to stay at NCIs, 82.8% stayed at institutions that only recruited children aged 0 - 3 years, 97.4% spent their whole day in NCIs, and 71.4% spent less than 3 000 CNY per month for NCI services. Additionally, over 95% of parents were satisfied with the food and care services in NCIs, as well as their children's physical development in NCIs. However, 32.1% of NCIs were reported by parents as having no room for breastfeeding. Conclusions Children's age, grandparent involvement in routine care, and family annual income are the main factors associated with children's attendance at NCIs. There is a greater need for more affordable and community-based NCIs, particularly for children under 2 years old. Additionally, more attention should be paid to the quality surveillance, assessment and management of NCIs.
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    Status of vitamin A, vitamin D and comorbidity of both deficiency in Chinese children
    YIN Shian, YANG Zhenyu
    Chinese Journal of Child Health Care    2024, 32 (3): 301-306.   DOI: 10.11852/zgetbjzz2024-0146
    Abstract458)      PDF (617KB)(435)      
    Vitamin A and vitamin D deficiencies or insufficiencies in children remain global public health problems. The deficiencies of both vitamin A and vitamin D exist in Chinese children, the deficiency of vitamin A is mainly marginal (about 30%) in children aged 0 - 12 years.Vitamin D deficiency and prevalence are common in healthy children aged 0 - 18 years, among which the severe deficiency rate is 2.46%, the deficiency rate is 21.57%, and the marginal deficiency rate is 28.71%.The deficiency rate gradually increases with the increase of age.Since the respective bioactive metabolites of vitamin A and vitamin D, retinoic acid and 1 and 25-dihydroxyvitamin D 3 have hormone-like properties, and both metabolites are synthesized from their vitamin precursors by different tissues and cells in the body, there may be a synergistic effect between both on target cells remotely by binding to nuclear hormone receptors.A high proportion of concurrent vitamin A and vitamin D deficiencies (comorbidities) in malnourished children under 5 years of age in low- and middle-income countries and poor areas will affect the immune response in a highly specific way, in addition to causing growth and developmental disorders (e.g., growth retardation, motor retardation), it also increases susceptibility to infectious diseases (e.g., recurrent respiratory infections, diarrhea), allergic diseases (e.g., asthma, atopic dermatitis), and neurodevelopmental disorders (touretic disorder, autism spectrum disorder).Therefore, children in the period of growth and development may benefit from supplementing with vitamin A and vitamin D.
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    New concepts of complementary feeding in infants and toddlers
    WANG Zhixu
    Chinese Journal of Child Health Care    2024, 32 (4): 362-367.   DOI: 10.11852/zgetbjzz2024-0250
    Abstract334)      PDF (1443KB)(457)      
    Infants go through a transition period before fully adapting to a diversified balanced diet after being breastfed, during which foods introduced other than milk, aimed at supplementing energy and nutrients, are referred to as complementary foods. The process of introducing complementary foods is called complementary feeding (CF). The purpose and significance of adding complementary foods include not only supplementing energy and nutrients, but also promoting the development of eating skills and fine motor functions, establishing healthy eating and food-related psychological behaviors, preventing food allergies and other allergic diseases, and materializing diversity of children's gut flora. The feeding suggestions of introducing red meat paste first other than iron-fortified baby rice flour at the age of 6 months, and rapidly achieving diversified food exposure, is comply with the above principles. This article analyzes the purpose of infant CF, reviews the historical development of CF, and interprets relevant feeding recommendations based on new concepts of CF.
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    Chinese Journal of Child Health Care    2024, 32 (9): 1040-1044.   DOI: 10.11852/zgetbjzz2023-0905
    Abstract334)      PDF (1724KB)(40)      
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    Infancy tummy time guideline
    WU Qiong, WANG Xiaotong, HUANG Yiwen, ZHANG Yanfeng, YANG Yufeng, ZHANG Ting, ZHU Zonghan
    Chinese Journal of Child Health Care    2024, 32 (8): 813-820.   DOI: 10.11852/zgetbjzz2024-0433
    Abstract289)      PDF (2211KB)(330)      
    Tummy time is defined as awake prone positioning with unrestricted movement of limbs, which is encouraged and supervised by adults. As one of the most important physical activities during early stages of life, tummy time plays a critical role in promoting gross motor and cognitive development, preventing plagiocephaly and decreasing overweight and obesity. Recently, the World Health Organization and many countries worldwide issued guidelines on tummy time for infants; however, there is no tummy time guideline in China. To fill in this gap, the Capital Institute of Pediatrics, together with experts from sports science, pediatrics and child health care, has jointly developed the Infancy Tummy Time Guideline. As the first tummy time guideline for infants under one year old in China, it aims to provide professional recommendations for both child care professionals and parents. The guideline raises recommendations from four aspects, including principles for tummy time, duration and frequency, types of tummy time activities, and monitoring and evaluation, which gives professional guidance on scientific and safe tummy time activities for infants to meet their developmental needs.
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    Intervention methods and development trends of autism spectrum disorder
    ZOU Hong, ZHU Jianfang, LUO Jiayi, LI Dandan, WU Di
    Chinese Journal of Child Health Care    2024, 32 (3): 317-321.   DOI: 10.11852/zgetbjzz2023-0684
    Abstract267)      PDF (624KB)(198)      
    Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which is manifested by symptoms such as difficulties in social interaction and communication, stereotypical repetitive behaviors, and narrow areas of interests.At present, the intervention methods for ASD mainly include behavioral intervention, pharmacological intervention, physical intervention, exercise intervention, complementary and alternative medicine intervention.With the progress of science and technology and in-depth research, the intervention methods of ASD will develop in the direction of personalized intervention, deep learning technology, gene therapy and neurofeedback technology.These new intervention methods would hopefully improve the treatment effect and the quality of life of patients.
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    Advances in clinical characteristics,diagnosis and treatment of children with developmental language delay
    SUN Yanhui, LI Yangfang
    Chinese Journal of Child Health Care    2024, 32 (9): 999-1003.   DOI: 10.11852/zgetbjzz2023-1386
    Abstract264)      PDF (676KB)(123)      
    Language delay is the most common developmental disorder in childhood,and as children grow older,it will have a lasting impact on their daily life and learning ability,and the impact on children's health can last into adulthood.Early active intervention and treatment will greatly improve the short-term and long-term adverse effects of abnormal language development on children,effectively promote the recovery of children's language ability.Language delay of children has been the current research hotspot.This article reviews the clinical characteristics,diagnosis and treatment of language retardation in children.
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    Advance in exercise intervention enhancing social function in children with autism spectrum disorder
    HOU Yaoqi, SONG Xiangqin
    Chinese Journal of Child Health Care    2024, 32 (3): 291-295.   DOI: 10.11852/zgetbjzz2023-1031
    Abstract256)      PDF (530KB)(183)      
    Autism spectrum disorder (ASD) is a commonly observed neuropsychological behavioral disorder in children.Communication difficulty is one of the typical symptoms, which may restrict building and maintaining of social relationship, cause severe impact on daily life and personal development.While traditional therapeutic approaches offer some effectiveness, they tend to be time-consuming and expensive.In contrast, exercise intervention, a burgeoning treatment strategy, has garnered widespread attention.Neurological studies validate that exercise can rectify brain functional anomalies in ASD patients and bolster their social skills.This paper synthesizes and analyzes existing studies on exercise intervention aimed at improving the social functioning of children with autism, offering a foundational reference for the development of therapeutic and interventional strategies for ASD.
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    Development and application of a Social-Emotional and Communicative Assessment Scale for preschool children in China
    WANG Jingtao, WU Qian, WEI Wenfei, DONG Kena, WANG Lin, LIU Ling, ZHU Zhongliang, LU Yushan, LI Hui
    Chinese Journal of Child Health Care    2024, 32 (7): 732-738.   DOI: 10.11852/zgetbjzz2023-0923
    Abstract253)      PDF (728KB)(130)      
    Objective To develop the Chinese Preschool Children Social Emotional and Communication Development Assessment Scale (CSECA), and to test its reliability and validity, in order to provide an objective standard for early intervention in clinical child care and mental health. Methods The scale development followed internationally recognized procedures and sampled 2 009 children aged 3 - 6 from Xi'an, Foshan, Jiujiang, and Tianshui using convenience sampling from December 2021 to December 2022. Then initial items were generated through interviews, and factor analysis was utilized for item screening and validity testing. Criterion-related validity was assessed through using the Strengths and Difficulties Questionnaire (SDQ) as a criterion measure. Results 1) The scale included five dimensions: sense of control, autonomy, emotional management, social skills, and emotional responsiveness, then the scale was divided into four subscales with 22, 24, 26, and 29 items, respectively. All subscales demonstrated good content validity, structural validity, and criterion validity, with cumulative variance contributions ranging from 57.80% to 66.58%. 2) The overall Cronbach′s α coefficients for the subscales ranged from 0.81 to 0.90, with individual dimension coefficients being 0.71 - 0.90. Criterion-related validity of CSECA varied from 0.573 to 0.849. Test-retest reliability for total scores of subscales was 0.78 - 0.89, and 0.51 - 0.58 for dimensions. 3) Scoring standards were categorized into four levels based on percentile ranges: < P 10, P 10 - P 50, P 50 - P 90, and > P 90, which were classified as low, general, good, and excellent level, respectively. 4) The positive rates of early warning signs for social emotional and communication skills were 9.38% for 3-year-old children, 29.44% for 4-year-old children, 11.80% for 5-year-old children, and 8.23% for 6-year-old children, with 4-year-old children displaying a notably higher detection rate in social emotions compared to other age groups. Conclusion The CSECA scale is successfully established and initially applied in clinical settings, which demonstrated a stable factor structure and good reliability and validity.
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    Challenge for diagnosis and treatment of attention-deficit/hyperactivity disorder comorbid with intellectual disability/developmental delay
    ZHANG Yiwen
    Chinese Journal of Child Health Care    2024, 32 (6): 581-585.   DOI: 10.11852/zgetbjzz2024-0567
    Abstract233)      PDF (669KB)(243)      
    Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and is one of the most common childhood disorders in those with intellectual disability/developmental delay (ID/DD). Patients with this comorbidity present complex symptoms and significant functional impairments, leading to difficulties in diagnosis and suboptimal treatment outcomes. Treatment of ADHD comorbid with ID requires a comprehensive approach that includes both non-pharmacological and pharmacological interventions. Overall, multidisciplinary comprehensive assessment and treatment, combined with long-term follow-up and individualized management, can help improve the quality of life and functionality of patients with this comorbidity.
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    Nutrition and brain development in early life
    SHAO Jie, GAO Jiaying
    Chinese Journal of Child Health Care    2024, 32 (4): 368-371.   DOI: 10.11852/zgetbjzz2024-0273
    Abstract230)      PDF (515KB)(303)      
    The early life period is a rapid period, as well as a critical/sensitive period for brain development. Proteins, long-chain polyunsaturated fatty acids (LCPUFAs), iron, zinc, iodine, folate, choline, vitamins A, D, B 6, and B 12, all play a role in key neural development processes and thus influence brain development. Different brain regions or circuits have specific critical periods during different stages of development that depend on specific nutrients. Any nutrient deficiency during this period, even if corrected with supplementation, may still affect the trajectory of brain development and result in long-term cognitive and behavioral impairment. This article elucidates the effects of major nutrient deficiencies during early life on brain development, the possible sensitive/critical timing, and the impacts on long-term cognitive and behavioral development, providing insights for the prevention and intervention of nutritional diseases and psychiatric developmental disorders, and the promotion of early childhood development.
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    Chinese Journal of Child Health Care    2024, 32 (11): 1161-1162.   DOI: 10.11852/zgetbjzz2024-1105
    Abstract215)      PDF (475KB)(222)      
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    Association between screen time and psychological behaviors of preschool children in Lanzhou City
    HUANG Lei, NAN Nan, SU Yue, WANG Pengli, WU Xiaoyan, GUO Jinxian
    Chinese Journal of Child Health Care    2024, 32 (3): 242-247.   DOI: 10.11852/zgetbjzz2023-0396
    Abstract211)      PDF (788KB)(174)      
    Objective To analyze the associations between different types of video screen time and psychological behaviors of preschool children, in order to provide evidence for promoting the development of children's mental health. Methods From February to March 2023, a total of 1 361 parents of children aged 3 - 6 years from 6 kindergartens of Lanzhou were surveyed by cluster sampling method.Parents were surveyed to obtain information about the video use, and the children's Strengths and Difficulties questionnaire (parent version) was used to assess children's psychological and behavioral problems. Results The rate of daily screen time exceeding standard was 36.96% (503/1 361).The screen time was mainly spent in watching TV cartoons, followed by educational APP.The detection rate of abnormal total difficulty score was 11.61% (158/1 361), and the abnormalities of peer communication (32.26%) and prosocial behavior (12.34%) were the most prominent.After adjusting for related factors by multiple Logistic regression analysis, total screen time≥2h/d ( OR=1.802) was found to be a risk factor for abnormal total difficulty score; watching TV cartoons≥2h/d was a risk factor for abnormal total difficulty score ( OR=2.409) and peer communication ( OR=2.222); playing games≥1h/d was a risk factor for abnormal total difficulty score, emotional symptoms, conduct problems, hyperactive behavior, and abnormalities of peer communication, the differences were all statistically significant ( P<0.05).However, educational APP screen time<1h/d was a protective factor for abnormal total difficulty score( OR=0.615) and prosocial behavior ( OR=0.549), but educational APP screen time≥2h/d was a risk factor for conduct problems ( OR=2.302), the differences were all statistically significant ( P<0.05). Conclusions The screen time of preschool children in Lanzhou cannot be ignored, and there is a significant correlation between overuse and children's psychological and behavioral problems.Parents and schools should attach importance to the parent-child and peer interaction of preschool children and strengthen the intervention of preschool children's video behavior.
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    Characteristics of cognitive function in children with attention-deficit/ hyperactivity disorder with different levels of attention and control
    LIU Ziqi, LIU Siqi, TAO Mengjiao, REN Yongying, LI Guannan, SUN Jing, WANG Xin, ZHANG Jianzhao, YANG Jian
    Chinese Journal of Child Health Care    2024, 32 (6): 591-596.   DOI: 10.11852/zgetbjzz2023-0969
    Abstract207)      PDF (615KB)(150)      
    Objective To analyze the characteristics of cognitive function in children with attention-deficit/hyperactivity disorder (ADHD) at different levels of attention and control,as well as their relationship with cognitive function. Methods A total of 104 children with ADHD who visited the Outpatient Department of Neurology and ADHD Clinic of the Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2022 to April 2023 were selected into this study to perform Wechwecht test,Integrated Visual and Auditory Continuous Performance Test (IVA-CPT),and cognitive function tests.According to the results ofIVA-CPT, children with ADHD were divided into attention deficit type (ADHD-I),hyperactive and impulsive type (ADHD-HI) and combined type (ADHD-C).SPSS 23.0 statistical software package was used to compare the cognitive function characteristics of the three subtypes of ADHD children,and the correlation of cognitive function with symptom scores,attention and control was analyzed. Results There were significant differences in intelligence quotient (IQ),mathematical cognitive ability,numerical reasoning ability,sequential relationship and short-term memory span (flashback) among the three groups( P<0.05).In pairwise comparisons,children with ADHD-HI showed superior IQ,mathematical cognitive abilities,numerical reasoning abilities,and sequential relationships compared to children with ADHD-C and ADHD-I ( P<0.05).The cognitive ability of ADHD children was positively correlated with IQ ( r=0.332 - 0.399, P<0.05).In the correlation analysis between cognitive function and IVA scores,sequential relationships and comparison performance were slightly positively correlated with IVA-CPT results in children with ADHD ( r=0.300 - 0.337, P<0.05).However,no significant correlation was found between cognitive function and SNAP-Ⅳ symptom scores ( r<0.3). Conclusions ADHD children with low attention level have poor cognitive functions.Attention is correlation with sequential relation and comparison size test scores.
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    Serum vitamin K 2 level in children and its correlation with bone mineral density
    WANG Peikang, JI Xia, ZHANG Man, ZHANG Xinkai, LIU Xing
    Chinese Journal of Child Health Care    2024, 32 (3): 286-290.   DOI: 10.11852/zgetbjzz2023-0711
    Abstract205)      PDF (634KB)(150)      
    Objective To analyze the clinical characteristics of serum vitamin K 2 in children and its correlation with bone mineral density, so as to provide reference for the prevention of insufficient bone strength in children. Methods A total of 4 145 children who underwent serum vitamin K 2 testing and physical examination at pediatric outpatient clinics of several municipal and county hospitals in Chongqing from January 2020 to March 2023 were retrospectively selected into this study for serum vitamin K 2-related analysis.Further 844 school-age children who completed serum 25-(OH)D and lumbar bone densitometry measurements were screened to analyze the correlation between vitamin K 2 level and bone mineral density. Results The overall serum vitamin K 2 deficiency rate was 61.6% (2 553/4 145), and the difference in serum vitamin K 2 deficiency rate between different age groups was statistically significant ( χ 2=39.364, P<0.05).The vitamin K 2 level of children was significantly influenced by season and maternal education level ( χ 2=45.310,9.990, P<0.05).There were significant differences in age ( Z=3.416), gender ( χ 2=9.218) and serum vitamin K 2 deficiency rate ( χ 2=5.826) between normal bone mass development group and insufficient bone mass development group ( P<0.05).Multivariate Logistic regression analysis suggested that vitamin K 2 deficiency was an independent risk factor for insufficient bone mass development in school-age children ( OR=1.37,95% CI:1.03 - 1.83, P=0.030). Conclusions There is a higher serum vitamin K 2 deficiency rate among children, especially infants and school-age children.Decreased bone mineral density in school-age children may be associated with serum vitamin K 2 deficiency.
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    Current status and recommendations for multimodal assessment of attention-deficit/hyperactivity disorder in children
    FENG Tingyong, WANG Xueke
    Chinese Journal of Child Health Care    2024, 32 (6): 586-590.   DOI: 10.11852/zgetbjzz2024-0434
    Abstract204)      PDF (595KB)(183)      
    Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder originating in childhood.Multimodal assessments not only provide a wealth of information to facilitate a more precise diagnosis of ADHD,but also lends critical support to the decision-making process involved in creating tailored and personalized therapeutic interventions.Therefore,this article delineates and examines the current status of ADHD assessment,multimodal assessment methods,and future development trends,with the aim of improving the understanding of multimodal assessment methods and enhancing the quality of diagnosis and treatment for children with ADHD through their application.
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    Study on the correlation between home rearing environment and social emotional competence of infants and toddlers
    XU Yuying, GUO Chenming, MEI Fangxuan, ZHANG Xi, YU Liping, DONG Jiali
    Chinese Journal of Child Health Care    2024, 32 (5): 559-565.   DOI: 10.11852/zgetbjzz2023-0892
    Abstract198)      PDF (645KB)(103)      
    Objective To understand the current situation of social emotional competence of infants and toddlers, and analyze its relationship with home rearing environment, in order to provide the basis for improving the level of infant social emotional development. Method A study was conducted on 390 individuals from a child health institution in Hubei and Henan provinces.The "Infant and Toddler Social-Emotional Assessment Scale" and "1 - 3Years Child Home Rearing Environment Scale" were used to investigate the social emotions ability and home rearing environment of infants and toddlers. Results A total of 390 valid questionnaires were collected in this survey, of which 199 were boys (51.0%) and 191 girls (49.0%).The average age of infants was (27.13±6.86)months.The age distribution is mainly among infants and young children aged 24 to 36 months, with a total of 305 people (78.2%).The caregiver′s registered residence ( Z=-3.570), father′s education level ( H=17.106), mother′s education level ( H=7.980), per capita monthly income of the family ( H=13.986), and the home rearing environment ( Z=-8.881) had statistical significance on the social emotional competence of infants( P<0.05 or <0.01).There was a significant positive correlation between family rearing environment and infants′ social emotion ( r=0.582, P<0.01).Multiple regression analysis showed that the social adaptation/self-care( β=0.30,95% CI:0.18 - 0.52, P<0.01)and language cognition dimensions( β=0.22,95% CI:0.07 - 0.59, P<0.05) in the home rearing environment had a statistically significant impact on the social emotional ability of infants and toddlers. Conclusion The home rearing environment is closely related to the social emotional development of infants and young children.Improve the parenting knowledge and skills of the main caregivers of infants and young children, build a good family rearing environment for infants and young children, which is beneficial to promote the development of children′s social emotions.
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    Research progress on the neurocognitive development of small for gestational age
    WANG Weiqin, LIU Zhongling, HUO Yanyan, WAN Qin, LIU Qiaoyun, WU Dan, CHEN Lingyan, CHEN Jinjin
    Chinese Journal of Child Health Care    2024, 32 (5): 527-533.   DOI: 10.11852/zgetbjzz2023-0382
    Abstract193)      PDF (804KB)(103)      
    Small for gestational age (SGA) infants are more likely to experience neurocognitive impairments compared to appropriate for gestational age (AGA) infants. This paper reviews recent research on the neurocognitive development of SGA children. SGA can lead to a "brain-sparing effect" due to growth restriction, which may affect cerebral blood flow and brain structure. However, this does not guarantee normal brain development. Restrictive blood flow can result in changes in brain structure, such as reduced total white matter and gray matter volume in various brain regions, including the cerebral cortex, hippocampus and cerebellum, ultimately leading to decreased head circumference. SGA children also exhibit lower scores in all neurocognitive domains, including intelligence, attention, memory, and executive function. This may result in poor academic performance and an increased risk of social, behavioral, and neurological problems, such as cerebral palsy, epilepsy, visual and hearing impairments, as well as comorbidities like attention deficit hyperactivity disorder(ADHD), autism spectrum disorder(ASD), anxiety, depression, and schizophrenia. Several risk factors for SGA-related neurocognitive impairments have been identified, including gestational hypertension, abnormal gestational weight, smoking, and catch-up growth. Studies have shown that the best interventions to improve cognitive dysplasia include nutrient supplementation, continued breastfeeding, high-quality education, and appropriate early intervention (responsive parenting) are effective in improving cognitive outcomes for SGA children.
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    Influencing factors of adaptive ability development of children aged 2 - 6 in China
    CUI Jiayin, LI Ruili, WANG Lihong, ZHENG Xiaoguo, YANG Huimin, ZHU Liqi, GUO Shuling, ZHAO Lu, ZHAO Wenhua, YANG Zhenyu, ZHANG Qian, WANG Yuying, XU Tao, CHEN Bowen
    Chinese Journal of Child Health Care    2024, 32 (3): 280-285.   DOI: 10.11852/zgetbjzz2023-1054
    Abstract192)      PDF (803KB)(136)      
    Objective To investigate the development of adaptability in children aged 2 - 6, and to explore its influencing factors, so as to provide reference for promoting the development of adaptability in young children. Methods Data were from the National Nutrition and Health Systematic Survey for Children in China, and 3 319 children aged 2 - 6 and their parents from 28 sites across 14 provinces were recruited in this study.The Development Scale for Children Aged 0 - 6 years (WS/T 580-2017) was used to measure the developmental quotient of children's adaptive ability, and a survey questionnaire was used to collect relevant information about children and their parents. Results Among 3 319 children aged 2 - 6, the proportion of slightly low or low level of adaptability, moderate adaptability development, good and excellent adaptability development was 7.68%,66.25% and 26.06%, respectively.The proportion of children aged 5 - 6 with good and excellent adaptability was lower in 3-year-old and 4-year-old groups ( χ2=59.29, P<0.05).Multiple stepwise linear regression showed that children's gender ( β=0.06), gestational age of birth ( β=-0.05), only child ( β=-0.04), left-behind child ( β=-0.04), the main caregiver ( β=-0.06), and the education level of parents =0.09, 0.10), whether parents actively pay attention to children's emotions ( β=-0.06) and whether children play with homemade toys ( β=-0.04) were the influencing factors of children's adaptive development quotient.Girls, full-term children, only children, non-left-behind children, children with parents as main caregivers, parents with a high level of education, parents who often take the initiative to pay attention to children's emotions, and children who play with homemade toys had a higher level of adaptability development quotient. Conclusions The development level of adaptability in children aged 2 - 6 in China is mostly above the average level and is related to multiple factors.Targeted intervention work can be carried out on relevant factors in order to promote the development of children's adaptability.
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    Research progress in the effects of the main active ingredients of breast milk on the intestinal and immune functions of infants
    LYU Lina, ZHU Bingquan
    Chinese Journal of Child Health Care    2024, 32 (4): 424-428.   DOI: 10.11852/zgetbjzz2023-0907
    Abstract192)      PDF (529KB)(109)      
    Gut microbiome plays an important role in maintaining lifelong health. Infancy is a critical period for the establishment of gut microbiota, which is influenced by many factors, including delivery methods, antibiotics, and feeding mode. Human milk contains a variety of bioactive factors, such as human milk oligosaccharide, secretory immunoglobulin, and human milk microbiota, which play important roles in the establishment and stability of newborn microbiota. This article presents the latest research progress on the effects of the aforementioned bioactive factors in breast milk on the colonization and development of infant microbiota, and explains how these substances affect immune function through intestinal bacteria.
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