Serum vitamin K2 level in children and its correlation with bone mineral density

WANG Peikang; JI Xia; ZHANG Man; ZHANG Xinkai; LIU Xing

doi:10.11852/zgetbjzz2023-0711

PDF(634 KB)

Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (3) : 286-290. DOI: 10.11852/zgetbjzz2023-0711

Original Articles

Serum vitamin K₂ level in children and its correlation with bone mineral density

WANG Peikang¹, JI Xia², ZHANG Man¹, ZHANG Xinkai¹, LIU Xing¹

Author information +

History +

Abstract

Objective To analyze the clinical characteristics of serum vitamin K₂ in children and its correlation with bone mineral density, so as to provide reference for the prevention of insufficient bone strength in children. Methods A total of 4 145 children who underwent serum vitamin K₂ testing and physical examination at pediatric outpatient clinics of several municipal and county hospitals in Chongqing from January 2020 to March 2023 were retrospectively selected into this study for serum vitamin K₂-related analysis.Further 844 school-age children who completed serum 25-(OH)D and lumbar bone densitometry measurements were screened to analyze the correlation between vitamin K₂level and bone mineral density. Results The overall serum vitamin K₂ deficiency rate was 61.6% (2 553/4 145), and the difference in serum vitamin K₂ deficiency rate between different age groups was statistically significant (χ²=39.364, P<0.05).The vitamin K₂ level of children was significantly influenced by season and maternal education level (χ²=45.310,9.990, P<0.05).There were significant differences in age (Z=3.416), gender (χ²=9.218) and serum vitamin K₂ deficiency rate (χ²=5.826) between normal bone mass development group and insufficient bone mass development group (P<0.05).Multivariate Logistic regression analysis suggested that vitamin K₂ deficiency was an independent risk factor for insufficient bone mass development in school-age children (OR=1.37,95%CI:1.03 - 1.83, P=0.030). Conclusions There is a higher serum vitamin K₂ deficiency rate among children, especially infants and school-age children.Decreased bone mineral density in school-age children may be associated with serum vitamin K₂ deficiency.

Key words

vitamin K₂ / bone mineral density / insufficient bone mass development / children

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

WANG Peikang, JI Xia, ZHANG Man, ZHANG Xinkai, LIU Xing. Serum vitamin K₂ level in children and its correlation with bone mineral density[J]. Chinese Journal of Child Health Care. 2024, 32(3): 286-290 https://doi.org/10.11852/zgetbjzz2023-0711

References

[1] Alonso N,Meinitzer A,Fritz-Petrin E,et al.Role of vitamin K in bone and muscle metabolism[J].Calcif Tissue Int, 2023,112(2):178-196.
[2] 何振丹,涂金伟,阮瑜,等.重庆市34219例儿童健康体检结果分析[J].保健医学研究与实践, 2022, 19(8): 16-20.
He ZD,Tu JW, Ruan Y, et al.Analysis of health examination results of 34219 children in Chongqing[J].Health Medicine Research and Practice, 2022, 19(8): 16-20.(in Chinese)
[3] 李辉,季成叶,宗心南,等.中国0～18岁儿童、青少年体块指数的生长曲线[J].中华儿科杂志, 2009, 47(7): 493-498.
Li H,Ji CY, Zong XN, et al.Body mass index growth carves for chinese children and adolescents aged 0 to 18 years[J].Chin J Pediatr, 2009, 47(7):473-498.(in China)
[4] 郑荣飞.重庆市6～18岁健康儿童的骨量和骨密度研究[D].重庆: 重庆医科大学, 2016.
Zheng YF.An evaluation of the bone mineral content and bone mineral density among children from 6 to 8 years old in Chongqing[D].Chongqing: Chongqing Medical University, 2016.(in Chinese)
[5] 刘军廷, 王亮, 孙景辉, 等.中国3~18岁儿童青少年骨密度参照标准:2013—2015年中国儿童青少年心血管健康研究横断面结果[J].英国医学杂志中文版, 2017,20(9):497-503.
Liu JT, Wang L, Sun JH, et al.Bone mineral density reference standards forchinese children aged 3-18: Cross-sectional results of the 2013-2015 china child and adolescent cardiovascular health (ccach) study[J].Chinese Edition of BMJ, 2017, 20(9):497-503.(in Chinese)
[6] Tsugawa N, Shiraki M.Vitamin K nutrition and bone health[J].Nutrients, 2020,12(7):1909.
[7] Tang H, Zhu Z, Zheng Z, et al.A study of hydrophobins-modified menaquinone-7 on osteoblastic cells differentiation[J].Mol Cell Biochem, 2021,476(4):1939-1948.
[8] 王倩, 赵莉, 武艳梅, 等.盘锦市0～6岁儿童骨密度调查及其与血清维生素K的关系研究[J].中国实用医药, 2020, 15(25): 164-165.
Wang Q, Zhao L, Wu YM, et al.Bone density survey of children aged 0-6 years inpanjin city and its relationship with serum vitamin K[J].China Practical Medical, 2020, 15(25): 164-165.(in Chinese)
[9] 杨钰儒, 王红, 许树红, 等.0～14岁儿童骨骼发育与维生素K的关联研究[J].中国儿童保健杂志, 2023,31(7):746-750.
Yang YR, Wang H,Xu SH, et al.Association between bone development and vitamin K in children aged 0 to 14 years[J].Chin J Child Health Care, 2023,31(7):746-750.(in Chinese)
[10] 完颜泽伟.维生素K缺乏与儿童骨代谢异常相关性研究[D].合肥: 安徽医科大学, 2021.
Wanyan ZW.Study on the correlation between vitamin K deficiency and abnormal bone metabolism in children[D].Hefei: Anhui Medical University, 2021.(in Chinese)
[11] 杜长秀, 李娜.1732例儿童血清维生素K2临床分析及其与骨代谢标志物关系的研究[J].中国当代儿科杂志, 2022, 24(10): 1130-1135.
Du ZX, Li N.Serum vitamin K2 level and its association with bone metabolism markers in 1 732 children[J].Chin J Contemp Pediatr,2022,24(10): 1130-1135.(in Chinese)
[12] 金轶.不同年龄段小儿骨骼维生素K营养状况的评价与分析[J].中国全科医学, 2013, 16(30): 2880-2882.
Jin Y.Evaluation and analysis of nutritional status of bone vitamin K in children of different age groups[J].Chin Gen Pract, 2013,16(30): 2880-2882.(in Chinese)
[13] Akbulut AC, Pavlic A, Petsophonsakul P, et al.Vitamin K2 needs an diseparate from vitamin K1[J].Nutrients, 2020,12(6):185.
[14] Inaba N, Sato T, Yamashita T.Low-dose daily intake of vitamin K(2) (menaquinone-7) improves osteocalcinγ-carboxylation: A double-blind, randomized controlled trials[J].J Nutr Sci Vitaminol(Tokyo), 2015,61(6):471-480.
[15] van Summeren MJ, Vermeer C, Engelbert RH, et al.Extremes in vitamin K status of bone are related to bone ultrasound properties in children with juvenile idiopathic arthritis[J].Clin Exp Rheumatol, 2008,26(3):484-491.
[16] van Summeren MJ, Braam LA, Lilien MR, et al.The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children[J].Br J Nutr, 2009,102(8):1171-1178.
[17] Kuang X, Liu C, Guo X, et al.The combination effect of vitamin K and vitamin D on human bone quality: A meta-analysis of randomized controlled trials[J].Food Funct, 2020,11(4):3280-3297.
[18] Solmaz I, Ozdemir MA, Unal E, et al.Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia:A prospective cohort study[J].J Pediatr Endocrinol Metab, 2021,34(4):441-447.