Vitamin D status of early infants in winter in northern China

Abstract

Abstract: Objective To explore vitamin D status of early infants and provide the evidence for the application. Methods 72 subjects were selected from the infants who were born in winter in northern China.All subjects took vitamin D supplement from the 15th day after birth and accepted history and physical examination during the medication monthly.Umbilical cord blood at birth and the blood of infants at 4 months were collected.The levels of serum 25-(OH)D,calcium,phosphorus and alkaline phosphatase were measured. Results The serum 25-(OH)D level was (21.91±5.75)nmol/L of cord blood and vitamin D status was deficiency in 72 (100.0%) cases.The serum 25-(OH)D level was (108.12±45.30) nmol/L of infants and vitamin D status was deficiency in 10(13.9%) cases.The serum 25-(OH)D levels of vitamin D daily supplement of 200U~,400U~ groups were (112.37±37.98)nmol/L and (133.97±34.93) nmol/L.There were 6(23.1%) cases of the serum 25-(OH)D levels ＜75nmol/L in daily intake of vitamin D 200U~ group and 2 cases (7.1%) in 400U~ group.Calcium,phosphorus,alkaline phosphatase levels of neonates and infants were normal. Conclusions Neonatal vitamin D deficiency is prevalent in the region.Intake sufficient vitamin D as soon as possible after birth could significantly improve neonatal and early infant vitamin D deficiency;vitamin D daily supplement of 200 U could significantly increase serum 25-(OH)D levels.In order to achieve adequate vitamin D nutrition for the general population,400U vitamin D is recommended.

Key words: vitamin D, 25-hydroxyvitamin D, cord blood, infants

摘要： 目的观察早期婴儿维生素D营养状况,为合理地补充维生素D提供依据。方法以我国北方地区冬季出生的72例婴儿为研究对象,自生后15 d起口服维生素D补充剂,满月起逐月询问生活史和体检。于出生及4月龄时分别采集脐血和静脉血,测定血清25-(OH)D、钙、磷和碱性磷酸酶浓度。结果脐血25-(OH)D平均水平(21.91±5.75)nmol/L,72例(100.0%)维生素D缺乏;婴儿4月龄时血清25-(OH)D平均水平(108.12±45.30)nmol/L,10例(13.9%)维生素D缺乏。血清25-(OH)D平均水平在每日摄入维生素D 200 U~组升至(112.37±37.98)nmol/L,在400 U~组升至(133.97±34.93)nmol/L。但维生素D不足和缺乏者在每日摄入维生素D 200 U~组6例(23.1%),400 U~组仅2例(7.1%)。新生儿及婴儿血钙、磷、碱性磷酸酶水平均正常。结论北方地区冬季新生儿普遍存在维生素D缺乏,生后尽早补充可以显著改善维生素D营养状况。每日补充200 U维生素D可显著提高早期婴儿血清25-(OH)D水平;若要达到维生素D营养充足,至少补充400 U维生素D。

关键词: 维生素D, 25-羟维生素D, 脐血, 婴儿

CLC Number:

R153.2

WANG Xiao-yan,JIN Chun-hua,WU Jian-xin,SUN Li-juan,LIU Zhuo,LI Yun-feng,WU Guang-chi. Vitamin D status of early infants in winter in northern China[J]. journal1, 2013, 21(11): 1178-1181.

王晓燕,金春华,吴建新,孙丽娟,刘卓,李云峰,吴光驰. 冬季早期婴儿维生素D营养状况观察[J]. 中国儿童保健杂志, 2013, 21(11): 1178-1181.

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