Abstract: Objective To systematically evaluate the correlation between vitamin D level and nonalcoholic fatty liver disease (NAFLD) in adolescents, in order to provide new ideas for the treatment of the disease. Methods The literatures regarding the correlation between NAFLD and vitamin D in adolescents from January 2013 to December 2022 were searched in PubMed, Embase, Cochrane Library, China knowledge Network and Wanfang database. Quality of the literature was evaluated by the Newcastle-Ottawa scale (NOS) and the adapted NOS quantitative change, and the Meta-analysis was carried out by Stata15.0. Results A total of 12 studies were included, including 922 adolescent NAFLD patients. Meta-analysis results showed that the level of 25(OH)D in NAFLD adolescents significantly decreased (SMD=-1.02, 95%CI: -1.54 - -0.49, I²=96.9%). The source of heterogeneity was not found in the subgroup analysis on the type of study and the degree of national development,but the vitamin level in each subgroup decreased. Sensitivity analysis excluded each study one by one, and the results did not change in essence, suggesting that the results were stable. No obvious publication bias was found. Conclusion The level of Vitamin D is decreased in adolescent patients with NAFLD, which may be involved in the development of NAFLD.

Key words: adolescent, vitamin D, nonalcoholic fatty liver disease, Meta-analysis

摘要： 目的 系统评价维生素D水平与青少年非酒精性脂肪性肝病(NAFLD)的相关性,为该病的治疗提供新思路。方法 检索PubMed、Embase、Cochrane Library、中国知网、万方数据库自2013年1月—2022年12月有关青少年NAFLD与维生素D相关性的文献。通过纽卡斯尔-渥太华量表(NOS)及改编后的NOS量变进行质量评价,采用Stata15.0进行Meta分析。结果 共纳入12篇研究,包括922名青少年NAFLD患者。Meta分析显示,NAFLD青少年25(OH)D水平降低(SMD=-1.02,95%CI:-1.54~-0.49,I²=96.9%)。根据研究类型及国家发展程度进行亚组分析,未找到异质性来源,但在各个亚组中NAFLD患者维生素D水平均降低;进行敏感性分析逐一排除各项研究,结果未发生本质改变,提示结果稳定;发表偏倚评价显示未存在明显发表偏倚。结论 青少年NAFLD患者维生素D水平降低,维生素D可能参与NAFLD的发展。

关键词: 青少年, 维生素D, 非酒精性脂肪性肝病, Meta分析