The influence factors of vitamin D and its correlation with vitamin K1 and K2 in children aged 0 - 6 years

CHEN Xiujin; JIANG Xiaolan; CHEN Hongyi; WANG Qi; CHEN Junlin

doi:10.11852/zgetbjzz2023-0964

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Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (9) : 1014-1018. DOI: 10.11852/zgetbjzz2023-0964

Clinical Research

The influence factors of vitamin D and its correlation with vitamin K1 and K2 in children aged 0 - 6 years

CHEN Xiujin, JIANG Xiaolan, CHEN Hongyi, WANG Qi, CHEN Junlin

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Abstract

Objective To investigate the factors influencing vitamin D status in children aged 0 - 6 years and its correlation with vitamins K1 and K2, in order to provide scientific grounds for promoting the healthy development of children in this area. Methods A total of 1 447 children aged 0 - 6 years, who underwent pediatric health follow-ups at Jianyang Maternal and Child Health Hospital between January 2021 and December 2022, were selected as study subjects. Serum levels of 25-(OH)D, vitamin K1, and vitamin K2 were obtained through laboratory tests. The current status of vitamin D, influencing factors, and its correlations with vitamins K1 and K2 were analyzed. Results Vitamin D was found to be correlated with both vitamins K1 and K2 (r=0.349 - 0.656, P<0.001). Protective factors against insufficient serum 25-(OH)D levels in children aged 0 - 6 years included mothers being under 35 years at childbirth (OR=0.467, 95%CI:0.318 - 0.823), mothers having education levels of junior college or above (OR=0.321, 95%CI: 0.253 - 0.373), children having a birth weight over 2 500g (OR=0.518, 95%CI: 0.377 - 0.672), and children regularly taking VD supplementation (400U/day) (OR=0.425, 95%CI: 0.341 - 0.613,P<0.05). Conclusions Greater emphasis is needed on the regular administration of vitamin D supplements by parents, accompanied by intensified health education efforts targeting low-birth-weight infants, older mothers, and those with lower educational backgrounds. For children deficient in vitamin D, closer attention should also be paid to their serum levels of vitamins K1 and K2.

Key words

vitamin D / vitamin K / coagulation function / children

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CHEN Xiujin, JIANG Xiaolan, CHEN Hongyi, WANG Qi, CHEN Junlin. The influence factors of vitamin D and its correlation with vitamin K1 and K2 in children aged 0 - 6 years[J]. Chinese Journal of Child Health Care. 2024, 32(9): 1014-1018 https://doi.org/10.11852/zgetbjzz2023-0964

References

[1] Peroni DG, Trambusti I, Di Cicco ME, et al. Vitamin D in pediatric health and disease[J]. Pediatr Allergy Immunol,2020,31(Suppl 24):54-57.
[2] Li J, Qin S, Zhang S, et al. Serum vitamin D concentration, vitamin D-related polymorphisms, and colorectal cancer risk[J].Int J Cancer,2023,153(2):278-289.
[3] 彭田川,喻梅.反复上呼吸道感染患儿维生素A和维生素D缺乏现状及与免疫功能的关系研究[J].中国医药导报,2022,29:97-100.
Peng TC, Yu M. Status of vitamin A and vitamin D deficiency and its relationship with immune function in children with recurrent upper respiratory tract infection[J]. China Medical Herald, 2022,29:97-100.(in Chinese)
[4] 闫玉辰,查云飞.维生素D与糖尿病骨病影像学研究进展[J].中国骨质疏松杂志,2021,27(3):450-453,458.
Yan YC, Zha YF. Research progress of vitamin D and diabetic bone disease imaging[J]. Chin J Osteoporos, 2021,27(3):450-453,458. (in Chinese)
[5] 张樊,唐鑫,张敏,等.原发性发育迟滞患儿血清维生素A、25-羟-维生素D3、维生素E含量及其与神经发育的相关性[J].中国医药导报,2022,19(17):96-99,103.
Zhang F, Tang X, Zhang M, et al. Serum levels of vitamin A, 25-hydroxyvitamin D3 and vitamin E and their correlation with neurodevelopment in children with primary developmental retardation[J]. China Medical Herald,2022,19(17):96-99,103.(in Chinese)
[6] 王淑慧,高雪婷,周银月,等.儿童运动发育迟缓与血碱性磷酸酶、血25-羟VD3表达水平的相关性[J].现代生物医学进展,2021,21(7):1356-1359,1314.
Wang SH, Gao XT, Zhou YY, et al. Correlation between motor retardation and expression levels of blood alkaline phosphatase and 25-hydroxyvitamin D3 in children[J]. Progress in Modern Biomedicine, 2021,21(7):1356-1359,1314.(in Chinese)
[7] Wang Z, Ding R, Wang J.The association between vitamin D status and autism spectrum disorder(ASD):A systematic review and Meta-analysis[J].Nutrients,2020,13(1):86.
[8] Liu Z, Huang S, Yuan X, et al.The role of vitamin D deficiency in the development of paediatric diseases[J].Ann Med,2023,55(1):127-135.
[9] 刁颖颖,岳保珠,张同清,等.儿童孤独症谱系障碍影响因素及与维生素D的关系分析[J].中国听力语言康复科学杂志,2021,19(2):156-160.
Diao YY, Yue BZ, Zhang TQ, et al.The influence factors of autism spectrum disorders in children and their relationship with vitamin D[J].Chinese Scientific Journal of Hearing and Speech Rehabilitation, 2021,19(2):156-160. (in Chinese)
[10] 李娟,唐琰捷,康英,等.6岁以下儿童VD营养状况及影响因素[J].中国妇幼健康研究,2022,33(4):109-114.
Li J,Tang YJ,Kang Y,et al.Vitamin D nutritional status and its influencing factors in children under 6 years old[J].Chinese Journal of Woman and Child Health Research,2022,33(4):109-114.(in Chinese)
[11] 赵艳,秦锐,马向华.江苏省0～5岁儿童维生素D营养状况研究[J].中国儿童保健杂志,2020,11:1214-1218.
Zhao Y, Qin R, Ma XH. Study on vitamin D nutritional status of 0 - 5 year old children in Jiangsu Province[J].Chin J Child Health Care,2020,11:1214-1218.(in Chinese)
[12] 梁珍花,戴艺,陶美娇,等.维生素A、E、D水平与儿童生长激素缺乏症的相关性研究[J].重庆医学,2021,50(1):77-80.
Liang ZH, Dai Y, Tao MJ, et al. Study on the relationship between vitamin A, E and D levels and growth hormone deficiency in children[J].Chongqing Medicine, 2021,50(1):77-80.(in Chinese)
[13] 杜长秀,李娜.1 732例儿童血清维生素K2临床分析及其与骨代谢标志物关系的研究[J].中国当代儿科杂志,2022,24(10):1130-1135.
Du CX, Li N. Clinical analysis of serum vitamin K2 and its relationship with bone metabolic markers in 1 732 children[J]. Chinese Journal of Contemporary Pediatrics, 2022,24(10):1130-1135.(in Chinese)
[14] Passeron T, Bouillon R, Callender V, et al. Sunscreen photoprotection and vitamin D status[J].Br J Dermatol,2019,181(5):916-931.
[15] 谢明玉,刘静,刘东强,等.东莞地区儿童维生素D缺乏现状及VD对血清铁蛋白及红细胞参数的影响[J].海南医学,2023,34(10):1461-1466.
Xie MY, Liu J, Liu DQ, et al. Status of vitamin D deficiency in children in Dongguan and effects of vitamin D on serum ferritin and erythrocyte parameters[J].Hainan Medical Journal,2023,34(10):1461-1466.(in Chinese)
[16] 马丽,李媛,耿立蒙,等.西安地区新生儿维生素D水平及影响因素分析[J].中国妇幼健康研究,2021,32(1):115-120.
Ma L, Li Y,Geng LM, et al. Analysis of neonatal vitamin D levels and its influencing factors in Xi 'an[J].Chinese Journal of Woman and Child Health Research,2021,32(1):115-120.(in Chinese)
[17] 尼玛顿珠,秦绪珍,边珍,等.拉萨地区1 196例藏族儿童维生素D营养状态分析[J].检验医学与临床,2022,19(10):1337-1339,1343.
Nima DZ, Qin CZ, Bian Z, et al. Analysis of vitamin D nutritional status in 1 196 Tibetan children in Lhasa[J].Laboratory Medicine and Clinic,2022,19(10):1337-1339,1343.(in Chinese)
[18] Balogun H, Jaakkola JJK, Amegah AK.Association of sunlight exposure and consumption of vitamin D-rich foods during pregnancy with adverse birth outcomes in an African population[J]. J Trop Pediatr,2019,65(6):526-536.
[19] 杨辉,余四旺,陈芳,等.中国营养与食品安全问题、对策与展望[J].中华预防医学杂志,2019,53(3):233-240.
Yang H, Yu SW, Chen F, et al.Problems, countermeasures and prospects of nutrition and food safety in China[J].Chin J Preventive Medicine,2019,53(3):233-240.(in Chinese)
[20] 林羿.中国高危妊娠研究的现状、问题和方向[J].上海交通大学学报(医学版),2022(4):403-408.
Lin Y. Status, problems and direction of high-risk pregnancy research in China[J].Journal of Shanghai Jiaotong University(Medical Science),2022(4):403-408. (in Chinese)
[21] 李晶,党少农,相晓妹.家庭社会经济状况与3岁以内儿童生长发育及营养状况的关系[J].中国儿童保健杂志,2022,30(1):80-83,101.
Li J,Dang SN,Xiang XM. Relationship between family socioeconomic status and growth, development and nutrition status of children under 3 years old[J]. Chin J Child Health Care, 2022, 30(1):80-83,101.(in Chinese)
[22] 游芳,孔庆平,强光峰,等.维生素D水平与极低出生体重儿临床结局的相关性研究[J].中国儿童保健杂志,2022,30(2):216-220.
You F, Kong QP, Qiang GF, et al. Correlation between vitamin D level and clinical outcome of very low birth weight infants[J].Chin J Child Health Care, 2022,30(2):216-220.(in Chinese)
[23] 侯秋英,林美玉,袁天明.晚期早产儿脐血维生素D水平及VD3补充对婴幼儿行为发育的前瞻性随机对照研究[J].中国当代儿科杂志,2022,24(11):1189-1194.
Hou QY, Lin MY, Yuan TM. A prospective randomized controlled study of umbilical cord blood vitamin D level and vitamin D3 supplementation on behavioral development of infants in late preterm infants[J]. Chinese Journal of Contemporary Pediatrics, 2022,24(11):1189-1194.(in Chinese)
[24] 王煚楠,徐佳丽,赵艺敏,等.维生素D缺乏经Hippo-YAP信号通路抑制胎盘发育诱发胎儿宫内生长受限[J].营养学报,2022,44(3):270-275.
Wang JN, Xu JL, Zhao YM, et al.Vitamin D deficiency induces fetal intrauterine growth restriction by inhibiting placental development via HiPO-YAP signaling pathway[J].Acta Nutrimenta Sinica,2022,44(3):270-275.(in Chinese)
[25] 刘黎明,帖利军,史晓薇,等.维生素K与儿童健康关系的研究[J].中国妇幼健康研究,2019,30(9):1039-1047.
Liu LM, Tie LJ, Shi XW, et al. Study on the relationship between vitamin K and children's health[J].Chinese Journal of Woman and Child Health Research,2019,30(9):1039-1047.(in Chinese)
[26] 李月,刘艳,路更,等.维生素K对CKD-MBD骨代谢异常以及血管钙化的治疗及作用机制[J].中国骨质疏松杂志,2022,28(2):308-312.
Li Y, Liu Y, Lu G, et al. Effect of vitamin K on CKD-MBD bone metabolism and vascular calcification[J].Chin J Osteoporos,2022,28(2):308-312.(in Chinese)