Objective To explore the expression and significance of serum cortisol, insulin growth factor binding protein-3(IGFBP-3), and 25-hydroxyvitamin D [25-(OH)D] in children with idiopathic short stature(ISS). Methods A total of 86 patients with ISS diagnosed and treated in Longquanyi District Maternal and Child Health Hospital of Chengdu from April 2020 to June 2022 were selected as the study subjects. Meabwhile, 43 children who took physical examination were enrolled into control group. Baseline data, serum cortisol, IGFBP-3, 25-(OH)D levels were compared. Pearson analysis was used to test the associations of cortisol, IGFBP-3, and 25-(OH)D with height, weight and body mass index(BMI). Logistic regression model was used to construct a combination model of cortisol, IGFBP-3 and 25-(OH)D for diagnosing ISS. The AUC value, sensitivity, and specificity of cortisol, IGFBP-3, 25-(OH)D and three combined indicators for diagnozing ISS were analyzed using the ROC curve model. Results Height, weight and BMI of the observation group were significantly lower than those of the control group(t=6.472, 15.193, 5.208, P<0.05). Serum level of cortisol in the observation group was significantly higher than that in the control group, while IGFBP-3 and 25-(OH)D levles were significantly lower than those in the control group(t=4.505, 5.341, 4.857, P<0.05). Pearson correlation analysis showed that serumcortisol level was negatively correlated with height, body weight and BMI(r＝-0.231,-0.716,-0.720, P<0.05), while serum IGFBP-3 and 25-(OH)D levels were positively correlated with height, body weight and BMI(r=0.200, 0.612, 0.636, 0.365, 0.716, 0.715, P<0.05). ROC curve analysis showed that the AUC values of cortisol, IGFBP-3, 25-(OH)D and three combined diagnosis of ISS were 0.750, 0.736, 0.728, 0.941(P<0.05), and the sensitivities were 54.70%, 93.00%, 90.70% and 93.00%, respectively, while the specificity was 88.40%, 53.50%, 51.20% and 79.10%, respectively. Conclusions Serum cortisol, IGFBP-3, 25-(OH) D levels show an abnormal expression trend in children with ISS. Monitoring the changes in their levels is beneficial to provide guidance for the early detection of ISS.
Key words
cortisol /
insulin growth factor binding protein-3 /
25-hydroxyvitamin D /
idiopathic short stature
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