Objective To investigate the possible role of common environmental hormones in the pathogenesis mechanism of precocious puberty of girls, in order to provide data for further researches on children's exposure to environmental hormones in Fuyang area. Methods Precocious puberty girls visited in Fuyang People's Hospital were randomly selected into this study from October 2020 to April 2021, including central precocious puberty(CPP) group (n=30), peripheral precocious puberty (PPP) group (n=30).Meanwhile, 23 cases healthy girls were selected into the normal control group. A questionnaire survey was conducted on the related ways of environmental hormone exposure. The exposure levels of 15 environmental hormones in urine samples of girls among the three groups were determined by ULTRA performance liquid chromatography-tandem mass spectrometry, and the serum levels of basic sex hormones and thyroid hormones in CPP and PPP groups were determined. Then the exposure levels of environmental hormones in urine samples of girls were analyzed among the three groups. Results There were significance differences in the use of plastic cups,the levels of MEHP and MBP in urine samples among girls in the three groups (χ2=8.111, F=3.741,5.672, P＜0.05). There were no significant differences in the exposure levels of MEHP and MBP in urine between CPP group and normal group (P > 0.05), but significant differences existed in the distribution of exposure levels of MEHP and MBP in urine between PPP and CPP groups, PPP and normal groups (P <0.05). The distribution of MEHP in PPP groups was positively correlated with E2 level (r=0.688, P< 0.05). Conclusions Frequent use of plastic products may lead to the onset of precocious puberty. Girls in Fuyang are generally affected by environmental hormones. Exposure to MEHP and MBP may play an important role in the pathogenesis of PPP and interfere with the secretion of sex hormones of individuals.
Key words
peripheral precocity /
environmental hormone /
monoethyl hexyl phthalate /
mono-butyl phthalate
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