Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children

LIU Haodong; LI Cheng; ZHAO Min; XI Bo

doi:10.11852/zgetbjzz2022-1360

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (7) : 707-712. DOI: 10.11852/zgetbjzz2022-1360

Basic Experimental Articles

Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children

LIU Haodong¹, LI Cheng¹, ZHAO Min², XI Bo¹

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Abstract

Objective To examine the relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia among children, in order to provide scientific basis for the prevention and treatment of hyperuricemia in children. Methods Data were from the baseline survey of the Huantai Childhood Cardiovascular Health Cohort Study conducted in Huantai County, Zibo City, Shandong Province from November 2017 to January 2018. A total of 1 202 children with complete data were included in this study. Covariance analysis was used to compare the difference in uric acid levels between children with normal waist circumference (WC), pre-abdominal obesity and abdominal obesity, and multivariate Logistic regression model was used to analyze the relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia among children, using normal WC as reference. Results After adjusting for all potential covariates, uric acid levels in children with pre-abdominal obesity [(289.7±80.6)μmol/L] and abdominal obesity [(332.2±87.8)μmol/L] were significantly higher than those with normal WC [(268.6±71.3)μmol/L] (F=88.51, P<0.05). Compared with children with normal WC, children with pre-abdominal obesity (OR=2.71, 95%CI:1.38-5.31) and abdominal obesity (OR=7.97, 95%CI:4.61-13.76) were at an increased risk of hyperuricemia(P<0.01). The results were similar when using waist-to-height ratio to determine abdominal obesity. Conclusion There is a positive relationship of abdominal obesity and pre-abdominal obesity with hyperuricemia in children, suggesting that more efforts should be made to reduce childhood abdominal obesity, in order to prevent the occurrence of childhood hyperuricemia.

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abdominal obesity / pre-abdominal obesity / hyperuricemia / children

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LIU Haodong, LI Cheng, ZHAO Min, XI Bo. Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children[J]. Chinese Journal of Child Health Care. 2023, 31(7): 707-712 https://doi.org/10.11852/zgetbjzz2022-1360

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