关键词: 瘦素, 体质指数, 肥胖, 幼儿

Abstract: Objective To explore the relationship between the serum leptin (LP) and development degree for obese children. Methods Height was measured with horizontal height analyzer.Serum LP was measured by ELISA,and t-test,Kruskal-Wallis H test,the rank conversion SNK test,the Spearman's rank correlation were used to analyze the data. Results 238 healthy children were inspected (male 121 cases,117 cases),152 cases in the normal group,61 cases in overweight group,25 cases in the obesity group;There had significant statistical difference in LP among the three groups(P<0.05);There had a positive correlation between serum LP and BMI(r_s=0.718,P<0.05);There had significant statistical differences in BMI among the three groups(P<0.05);There had no significant statistical difference in BMI between male and female in three groups(P>0.05). Conclusions With BMI increasing,serum LP is rising,a positive correlation between them indicates that obesity children may exist LP resistance.

Key words: leptin, body mass index, obesity, children