Table of Content

10 August 2016, Volume 24 Issue 8

Previous Issue    Next Issue

Research of the change characteristics of the cerebrospinal fluids matrix metalloproteinase-9 in 60 cases of full-term newborns with hypoxic-ischemic encephalopathy.

WANG Qi,CHAI Yan-nan,CHEN Chang-chun,YAN Yan,YIN Xiao-juan.

2016, 24(8):  788-790.  DOI: 10.11852/zgetbjzz2016-24-08-02

Asbtract ( )   PDF (579KB) ( )  

References | Related Articles | Metrics

Objective To explore the change characteristics of the cerebrospinal fluids matrix metalloproteinase-9 (MMP-9) in different severity levels of hypoxic-ischemic encephalopathy (HIE). Method Totally 60 HIE child patients were selected as the subjects and they were divided into three groups:the mild group,the moderate group and the severe group in terms of the severity,20 patients in each group.The 1^st,7^th,14^th and 21^st day were the time points after the seizure,the ELISA method was employed to detect the levels of MMP-9.Electroencephalography (aEEG) was also monitored with an observing table to record the clinical data. Results The detected levels of MMP-9 were different in different time points for the HIE with the same severity.The different levels of MMP-9 in different time points in the HIE mild group showed no statistic significance (P>0.05).The HIE moderate group and the HIE severe group showed statistic significances (P<0.05).The detected levels of MMP-9 were also different at the same time point for the HIE with the different severity.The 1^st day MMP-9 levels showed statistic significance (P＜0.05) among the three groups.The 7^th day showed statistic significance between the mild and moderate group,between the moderate and severe group (P＜0.05).The 14^th and 21^st day showed statistic significance between the mild and severe group (P＜0.05).The 21^st day showed statistic significance between the MMP-9 with different prognoses (P＜0.05),and there was a weak correlation between MMP-9 levels and the HIE prognosis (P=0.007).On the 1^st,14^th and 21^st day,the MMP-9 levels changed in certain correlation with the 60 cases (P<0.05). Conclusions The levels of the cerebrospinal fluids MMP-9 are in correlation with the severity of HIE and can be used as an indicator for the early treatment and prognosis of HIE.

The amino acid and acylcarnitine profile of full-term and premature newborns by LC-MS/MS.

YAN Lei,YANG Yao,WANG Yan,FENG Zhi-chun.

2016, 24(8):  791-794.  DOI: 10.11852/zgetbjzz2016-24-08-03

Asbtract ( )   PDF (565KB) ( )  

References | Related Articles | Metrics

Objective To measure the amino acid and acylcarnitine in blood of full-term and premature newborns by LC-MS/MS,establish the normal range of different gestational ages for diagnosis of inborn error of metabolism,and explore the development of newborns at the metabolic level. Methods A total of 1 652 premature newborns in hospital from January 2013 to November 2015 were tested.524 normal full-term newborns were collected for the control group.The dry blood spot samples were collected and detected by tandem mass spectrometry for amino acids and acylcarnitines analysis. Results There were significant differences in the normal full-term and premature newborns for most of the amino acids and acylcarnitines (P<0.01).Twelve amino acids and six acylcarnitines levels of the the normal full-term newborns were significantly higher than those of the premature newborns.Six amino acids and twenty acylcarnitines levels of the the normal full-term newborns were significantly lower than those of the premature newborns. Conclusions The significantly difference of different ages (full-term and premature) is evaluated at the metabolic level.The normal range of different ages is established for diagnosis of inborn error of metabolism.The development of newborns is explored at the metabolic level.

Screening of double oxide enzyme mutations in patients with congenital hypothyroidism.

HAN Wen-xiu,ZANG Hong-wei,ZANG Yu-cui,YI Ming-ji,YAN Sheng-li,LIU Shi-guo,GE Yin-lin.

2016, 24(8):  795-799.  DOI: 10.11852/zgetbjzz2016-24-08-04

Asbtract ( )   PDF (657KB) ( )  

References | Related Articles | Metrics

Objective To study the types and characteristics of double oxide enzyme (DUOX1) mutation in patients with congenital hypothyroidism (CH) and thyroid goiter from Shandong province,and provide theoretical basis for the diagnosis and treatment of CH. Methods Totally 100 healthy individuals and 43 cases of patients who were diagnosed as congenital hypothyroidism (CH) were extracted their genomic DNA from peripheral blood and thyroid goiter in neonatal screening in Shandong Province.All the exons of DUOX1 were amplified by polymerase chain reaction (PCR) and direct sequencing (Sanger sequencing),DUOX1 gene was analysed whether there was mutation combining with the results of DNA sequencing and bioinformatics analysis,and χ² test was used. Results No DUOX1 gene mutation was found in 43 cases of CH with thyroid goiter patients and 100 healthy individuals enrolled according to the sequencing results and bioinformatics analysis,however,two SNPs were found (rs16939752,c.3076T>C; rs1706804,c.3228A>G) in exon region,the former was a missense mutation (Cys→Arg),the latter was a synonymous mutation (Thr→Thr); one SNP was found (rs2020216,IVS8+129C>T) in intron region.There was no significant difference between the SNP rate in CH patients and controls(P>0.05). Conclusion The DUOX1 gene mutation rate is very low which may not be the main factor leading to the congenital hypothyroidism with thyroid goiter in Shandong province,China.

Evaluation for the effect of family-based conductive education training on infant's cognitive-motor development.

CAO Zhi-juan,SU Xiu-juan,ZHU Qing-qing,WANG Wei-jie,HUANG Dan,HUA Jing.

2016, 24(8):  800-803.  DOI: 10.11852/zgetbjzz2016-24-08-05

Asbtract ( )   PDF (559KB) ( )  

References | Related Articles | Metrics

Objective To evaluate the effectiveness of family-based conductive education training on cognitive-motor development among 3~12 month old premature and full-term infants. Methods 273 infants who went to child health clinic of our hospital during the period of October 2014 to October 2015 were distributed to the intervention group and 1 572 infants who went to child health clinic of other hospitals were distributed to the control group.Intervention was only conducted among intervention group infants.Cognitive-motor developmental level was measured by ASQ-3 and compared through regression equation between intervention group and control group. Results The ASQ total score existed none statistical difference(P>0.05) between intervention group and control group among full-term infants;On the contrary,there existed significant statistical difference (P<0.01) between intervention group and control group among the preterm population,the ASQ total score of intervention group was higher than that in the control group with an average of 5.554 points. Conclusion The family-based conductive education training intervention on cognitive-motor development is effective for the premature infants and it is worthy to be popularized.

Quality of life and related factors in children with attention deficit hyperactivity disorder.

ZHANG Yue-bing,LI Rong-qin,WANG Ai-qin,ZHANG Guo-hua,LIU-Xia,WEI Hong-kai,SHANG Lu-ning.

2016, 24(8):  804-806.  DOI: 10.11852/zgetbjzz2016-24-08-06

Asbtract ( )   PDF (570KB) ( )  

References | Related Articles | Metrics

Objective To study the quality of life and related factors in children with attention-deficit /hyperactivity disorder (ADHD). Methods 96 patients meeting the diagnoses of ADHD according to the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition (DSM-Ⅳ) were selected into test group.110 healthy children were selected into control group.Inventory of Subjective Life Quality(ISLQ),Achenbach's Child Behavior Checklist (CBCL) and Egma Minnen av Bardndosnauppforstran(EMBU)were administered to them. Results The ADHD patients had lower scores of the quality of life in aggregate score,family life,peer intercommunions,living conditions,anxiety experience,depression experience,cognitive components and emotional components than healthy children (P＜0.05).Correlation analysis showed that scores of parents' affection warmth was positively correlated with scores of quality of life.However,the scores of aggressive behaviors,attention deficiency,father's punishment were negatively correlated with scores of quality of life. Conclusion The quality of life in ADHD is obviously lower than healthy children.Attention deficit symptom and poor parental rearing practices are negatively associated with quality of life.

Influence of early different doses of intravenous amino acid supplementation on preterm infants' nutrition.

TAN Jian-min,ZHENG Yu-qiong,WAN Hong,LUO Tian-kuan,SHEN Chuan-qiao,YANG Li-na.

2016, 24(8):  807-809.  DOI: 10.11852/zgetbjzz2016-24-08-07

Asbtract ( )   PDF (421KB) ( )  

References | Related Articles | Metrics

Objective To assess the effectiveness of early different doses of intravenous amino acid supplementation in preterm infants. Methods According different intravenous amino acid administration,one hundred and forty-six preterm infants (fetal age 29~34,birth weight 1 150~2 250 g) were randomly divided into low dose,median dose,high dose groups.The infants in high dose group were treated with amino acid 2.0 g/(kg·d) within 24 hours,increasing by 1.0 g per day;The median dose group was treated with amino acid 1.0g/(kg·d),increasing by 0.5 g per day;The low dose group was treated with amino acid 0.5 g/(kg·d),increasing by 0.5 g per day. Results The time of rebounding to birth weigh in the high dose group was less than that in the median and low dose group;In two weeks after birth,the rate of weight again in the high dose group was highest than that in other dose groups;In the high dose group,time of achieving enteral nutrition of 100 kCal/kg days was lower than that in other dose groups (P<0.05).On the fourteenth day after birth,there was no significant difference in urea nitrogen,creatinine,PH value,base excess,serum bilirubin and total bile acid among the three groups (P>0.05). Conclusion Early higher doses of amino acid supplementation is beneficial to preterm infants' early growth and nutrition with little incidence of metabolic acidosis,renal dysfunction or cholestasis.

The clinical research of the nasal synchronization intermittent positive pressure ventilation in treating freqent apnea of premature infants.

ZENG Jun-an,KE Hua,LI Zhan-kui,LI Hui.

2016, 24(8):  810-813.  DOI: 10.11852/zgetbjzz2016-24-08-08

Asbtract ( )   PDF (569KB) ( )  

References | Related Articles | Metrics

Objective To investigate the therapeutic effects on premature infant apnea by the two different treatments of the nasal synchronization intermittent positive pressure ventilation (NSIPPV) and nasal continuous positive airway pressure (NCPAP). Methods NSIPPV group included 40 cases of frequent apnea on premature infants with gestational age≤34 weeks treated in Northwest Women and Children Hospital during the period from January 1,2015 to December 31,2015.And NCPAP group included randomly selected 40 cases of frequent apnea on premature infants with gestational age≤34 weeks treated in Northwest Women and Children Hospital during the period from January 1,2014 to December 31,2014.There were no significant differences in their gestational ages at birth and birth weights.The two groups were given comprehensive treatments and the effects were observed. Results NSIPPV group had higher efficiency (P<0.01).The two groups were respectively given assisted ventilation for 1 h,12 h,24h,48h,and there were significant differences in pH,PCO₂,PO₂ indicator (P<0.01).There were significant differences between the two groups in the total ventilation time and total oxygen exposure time (P all<0.01).Rate of switched to intubation and the probability of mechanical ventilation of NSIPPV group after treatment failure was significantly less than that of NCPAP group (P<0.01).The NSIPPV probability of air leak was lower than NCPAP (P<0.01). Conclusion NSIPPV is more effective than NCPAP on preterm infants with frequent apnea,blood gas results were improved significantly.The probabilities of intubation and mechanical ventilation,air leak are reduced.The overall time assisted ventilation are also reduced.

The characteristics of temporal processing in childreh with attention deficit hyperactivity disorder.

LI Ying,YANG Bin-rang,PENG Gang,LI Jian-ying,YANG Si-yuan.

2016, 24(8):  814-817.  DOI: 10.11852/zgetbjzz2016-24-08-09

Asbtract ( )   PDF (522KB) ( )  

References | Related Articles | Metrics

Objective To determine cognitive function domains of temporal processing,the possible etiopathogenisis,and to supply scientific evidence for intervention of attention deficit hyperactivity disorder (ADHD)children. Methods One hundred children with ADHD and 100 healthy controls matched in age,gender,grade,handedness were measured with neuropsychological tests concerning the domain of temporal processing (i.e,time production).The performances were compared using repeated measurement of multivariate analysis of variance (MANOVA) and MANCOVA with FIQ controlled between two groups. Results The omnibus MANOVA had group and duration main effects and interaction effect in time production task,the absolute discrepancies,the accuracy coefficients were significant different.The results showed that the abosulte discrepancyies were greater and the accuracy coefficients were less in children with ADHD than those in healthy controls.The performance in both groups became worse with the time duration increasing,but much worse in children with ADHD.The results remained unchanged after controlling for FIQ.The ACOVAs of each duration showed that children with ADHD performed worse than healthy controls in the long durations. Conclusion Temporal processing deficiency may be inherent and not stem from other cognitive deficiencies.

Childhood psychological abuse and adaptability of college freshmen:The mediating role of automatic thoughts and the moderating role of social support.

WANG Yu-hua,YU Zeng-yan.

2016, 24(8):  818-820.  DOI: 10.11852/zgetbjzz2016-24-08-10

Asbtract ( )   PDF (433KB) ( )  

References | Related Articles | Metrics

Objective To constructe relational model between freshmen's childhood emotional maltreatment and social adaptability by using path analysis and other empirical methods,and explore the mediating effects of automatic thoughts and moderating effects of social support. Methods A stratified cluster sample of 553 college freshmen from a certain college of Heilongjiang Province were surveyed with the Childhood Psychological Maltreatment Scale (CMPS).The Automatic Thoughts Questionnaires (ATQ),The Social Support Scale and The China College Student Adjustment Scale(CCSAS). Results Analyses of the mediation model showed a good fit to the data,and revealed that the relationship between childhood emotional maltreatment and social adaptability was mediated by automatic thoughts (χ²/df=3.46,P≤0.001,AGFI=0.93;GFI=0.96;CFI=0.95,NFI=0.94;IFI=0.96;TLI=0.93;RMSEA=0.067);The social support regulated the second half intermediary effect path on the psychological abuse-automatic thinking-social adaptability(a₁=0.275,t=6.700,P<0.001;b₂=-0.152,t=-3.941,P<0.001). Conclusion Effective intervention by changing negative thoughts and providing social support is benefit for young adults with childhood emotional maltreatment.

Association of Dll4 and VEGFR-1,VEGFR-2 in mice model of oxygen-induced retinopathy.

LIU Wang-kai,SU Yi-hua,LI Yi-juan,YU Mu-xue,LI Xiao-yu,HUANG Yue-fang,ZHUANG Si-qi.

2016, 24(8):  821-824.  DOI: 10.11852/zgetbjzz2016-24-08-11

Asbtract ( )   PDF (644KB) ( )  

References | Related Articles | Metrics

Objective To investigate the role that Notch1-Dll4 signal pathway played in the oxygen-induced retinal neovascularization of mice by analyzing the expression of Dll4,VEGFR-1,and VEGFR-2 in retinal neovascularization. Methods Thirty 7-day-old C57BL/6J mice were divided into oxygen-induced retinopathy group and control group.In oxygen-induced retinopathy group,15 mice were exposed to (75±2) % oxygen for 5 days and then back to room air.In control group,15 mice were raised in room air.5 mice were taken from each group at p7(postnatal seventh day),p12 and p17 respectively,and then enucleated the eyeballs to detect the Dll4,VEGFR-1 and VEGFR-2 by immunohistochemistry. Results There were Dll4,VEGFR-1 and VEGFR-2 positive cells in the retina of both groups.The positive rate of VEGFR-1 had no difference between two groups in p7 and p12 (P＞0.05).While in p17,the positive rate of VEGFR-1 in oxygen-induced retinopathy group was lower than that in control group(P<0.05).The positive rate of VEGFR-2 had no difference between two groups in p7,p12,p17(P＞0.05).The positive rate of Dll4 had of no difference between these two groups in p7(P＞0.05),and in p12 and p17,the positive rate of Dll4 in oxygen-induced retinopathy group was lower than that in control group (P₁₂＜0.05,P₁₇＜0.001).In oxygen-induced retinopathy group,the positive rate of VEGFR-1 and Dll4 decreased from p7 to p17(P＜0.001,P＜0.001),and that of VEGFR-2 increased from p7 to p17 (P＜0.05).In control group,the positive rate of VEGFR-1 showed a decreased tendency at different timing(P＜0.05=0.017),and that of VEGFR-2 increased at different timing(P＜0.001),while that of Dll4 didn't changed obviously(P＞0.05). Conclusion Notch1 - Dll4 signaling pathway may be involved in the regulation of VEGF in the process of retinal angiogenesis.The expression of Dll4 is inhibited in oxygen-induced retinopathy mice during the formation of neovascularization,so it failed to show negative feedback regulation to VEGF; The expression of VEGFR-1 is inhibited in oxygen-induced retinopathy mice and has a consistent trend with Dll4.

Mechanism of Erythropoietin-induced hypoxic-ischemic brain injury protection.

CHEN Qin-ling,JIANG Hui-ying,YANG Mei,LI Xiao-dong,ZHAO Xiao-li.

2016, 24(8):  825-828.  DOI: 10.11852/zgetbjzz2016-24-08-12

Asbtract ( )   PDF (678KB) ( )  

References | Related Articles | Metrics

Objective To assess the expression levels of excitatory amino acid transporter 2 (EAAT2) in classical rat model of hypoxic ischemic encephalopathy (HIE),and the expression level of that after erythropoietin (EPO) treatment. Methods Totally,108 postnatal 72 h SD rats were randomly assigned into six groups,including control,hypoxia,ischemia,hypoxia-ischemia,EPO treatment,and saline treatment.A neonatal rat model of HIE by bilateral ligation of carotid artery and subsequent anaerobic treatment for 2 hrs was constructed.The behavior of rats was recorded.The expression level of EAAT2 was assessed by Western blotting.Moreover,mRNA levels of EAAT1 and EAAT2 was measured using real time polymerase chain reaction. Results Typical HIE characteristics were observed on the models.The mRNA level of EAAT1 and expression level of EAAT2 was obviously reduced after hypoxia,ischemia,and hypoxia-ischemia.After treatment by EPO,the expression levels of EAAT1 and EAAT2 increased.Moreover,the gene expression levels in cortex were higher than that in hippocampe. Conclusion Reduced EAAT2 expression levels may be one reason for the development of HIE,which might also contribute to the curative effect of EPO.

Meta-analysis of ganglioside treatment for children with cerebral palsy.

PAN Zi-qi,LIU Yan,ZHENG Wei,ZHANG Jian,ZHANG Yu-mei.

2016, 24(8):  842-845.  DOI: 10.11852/zgetbjzz2016-24-08-17

Asbtract ( )   PDF (531KB) ( )  

References | Related Articles | Metrics

Objective To evaluate the efficacy and safety of gangliosides in the treatment of children with cerebral palsy,to provide some evidence for its clinical application. Methods The papers related to gangliosides in the treatment of children with cerebral palsy were searched in PubMed,EMBASE,Cochrane library,CBM,CNKI,CSPD (form establishments to October 2015).Randomized controlled trials on the treatment of cerebral palsy with gangliosides were included and assessed for quality.A Meta-analysis was conducted to evaluate the effectual rate and effective rate of the trials as ordinal categorical variable,to evaluate the total effective rate as binary variable,to evaluate the DQ(developmental quotient) value as continuous variable. Results A total of 10 randomized controlled trial 806 cases of children were included in the study,the OR(odds ratio) values of effectual and effective rate was 2.63 (1.95~3.53);the OR value of total effective rate was 4.74 (2.99~7.52);the DQ scores were increased,SMD=1.30,95%CI=0.33~2.27. Conclusion The efficacy of gangliosides in the treatment of children with cerebral palsy is well,and the DQ value of the children are improved.

Analysis of retinopathy screening in 11 553 newborns.

ZHANG Min,SUN Ming,CHENG Kai,YANG Hai-xia,ZHANG Lin-na.

2016, 24(8):  846-849.  DOI: 10.11852/zgetbjzz2016-24-08-18

Asbtract ( )   PDF (555KB) ( )  

References | Related Articles | Metrics

Objective To screen and analyze the incidence of retinopathy in newborns. Methods Retinopathies in newborns born from September 1,2014 to August 31,2015 in our hospital were analyzed retrospectively.All newborns were classified into 3 groups:normal newborns,high-risk newborns,and premature newborns according to their clinical conditions.Incidence of retinopathy in normal newborns was compared with high-risk newborns and premature newborns separately. Results Overall,3 001 of 11 553 (25.98%) newborns were found to have retinopathy.The incidence of retinopathy among normal newborns was 25.20% (2 512/9 967).The incidence among high-risk newborns was 31.96%(272/851),and higher than that in normal newborns.In addition,the incidence among premature newborns(29.52%,217/735) was also higher than that in normal newborns. Conclusions The incidences of retinopathy in high-risk newborns and premature newborns are significantly higher than that in normal newborns.Early screening can contribute to early detection and intervention of retinopathy in newborns,and help saving visions and even lives.

The prevalence and risk factors of asthma in children in two districts of Yunnan Province.

QI Zhi-ye,DUAN Jing,SHI Ting-ming,ZHANG Quan,JI Hong-yan,CAO Zhi-lang,LU Ping.

2016, 24(8):  850-852.  DOI: 10.11852/zgetbjzz2016-24-08-19

Asbtract ( )   PDF (568KB) ( )  

References | Related Articles | Metrics

Objective To understand the prevalence,risk factors and treatment of asthma in children in urban areas of Yunnan province and provide evidence for standardized diagnosis,treatment and prevention. Methods Children were selected by random cluster sampling.Standardized preliminary questionnaire was used for screening out possible patients in the survey.Diagnosis of asthma was confirmed by diagnostic criteria in suspected asthmatic children.Asthmatic children were further asked for past diagnosis and treatment with the questionnaire of asthma in children.Double entry and validation were adopted for all data and analysis were carried out using Epi-Info software. Result The total asthma incidence rate was 1.24%.In all asthmatic children,66.37% were previous diagnosed with classical asthma or cough variant asthma.Antibiotics were used in 69.64%,bronchodilators in 54.76%,inhaled corticosteroid in 60.71%.Family history of allergy,premature delivery,house decoration,tobacco smoke exposure were independent risk factors for the onset of asthma. Conclusions Compared with 10 years ago,the total asthma incidence of childhood asthma aged 0~14 year old in urban district of Yunnan Province is significantly increased.The treatment and management of asthma in children awaits improvement as well.Prevention of premature birth,reduction of indoor and outdoor pollution,timely treatment of allergic diseases and prevention of respiratory tract infections are effective ways to reduce the prevalence of asthma and prevent asthma attacks.

Analysis on detection results of mumps antibody levels in 3 to 15 years old students in high-tech industrial development zone,Urumqi.

GUO Qi,ZHU Yang,WANG Yi,XIN Xiu-mei.

2016, 24(8):  853-855.  DOI: 10.11852/zgetbjzz2016-24-08-20

Asbtract ( )   PDF (411KB) ( )  

References | Related Articles | Metrics

Objective To detect and analyse mumps virus antibody levels of 3 to 15 years old children and adolescents in High-tech Industrial Development Zone,Urumqi,and provide the basis for the formulation and adjustment mumps prevention and control strategies. Method By adopting the cluster sampling method,560 students aged 3 to 15 were select from six schools in High-tech Industrial Development Zone,Urumqi.The antibody of serum was detected by ELISA. Results The mumps virus antibody positive average rate was 78.92% in different age groups,the highest positive rate was found in the age group of 7~ and 14~15 up to 90%,the positive rate was decreased with the growth of age in the other groups,and was at its lowest in 5 to 12 years old; There was no significantly difference of mumps virus antibody positive rate in different gender and nation; Students of residence antibody positive rate was higher than shack students,and antibody positive rate was in proportion to the doses of vaccination. Conclusion Mumps virus antibody-positive rate in 3 to 15 years old students is lower in high-tech industrial development zone,Urumqi.The inoculating units should strengthen the management of floating children,improve the mumps vaccination rates in school-age children and succeed in doing preschool check verification and second dose of strengthening to prevent the disease outbreaks in our region.

Analysis on vision screening results of 17 129 preschool children.

ZHANG Pei-bin,YANG Ling,WU Hai-xia,BAI Ling.

2016, 24(8):  856-858.  DOI: 10.11852/zgetbjzz2016-24-08-21

Asbtract ( )   PDF (419KB) ( )  

References | Related Articles | Metrics

Objective To measure the vision screening to 3~6 years old children,and the follow-up to the abnormal children of vision screening,analyse preschool children's abnormal rate and the causes of abnormal vision screening results in Pukou district in the year of 2014,and carrie out the status of preschool children's visual impairment. Methods The vision screening included the using of Suresight screening instrument to check up the refractive errors and anisometropia,and the using the methods of the corneal reflection and the covered tests for dominant eye strabismus.The children with abnormal vision screening results would be in visit for further examination specialized amblyopia,strabismus and other eye diseases. Results The vision screening coverage rate of preschool children was 93.13% in 2014,the vision screening abnormal rate was 7.39%.The refractive errors and anisometropia accounted for 88.85% of total abnormal children by vision screening.Strabismus incidence was 0.36%,the incidence of exotropia was significantly higher than esotropia.Strabismus incidence and vision screening abnormal rate had no significant relation with gender.There were 345 children with vision screening abnormal to the Maternal and Child Health Care Institute for further examination,168 cases diagnosed with amblyopia and strabismus and other eye diseases,the diagnosis rate was 48.69%,the incidence of visual impairment was 3.60%. Conclusion The main causes of abnormal children by vision screening are the refractive errors and anisometropia,followed by strabismus,and the vision screening is the early method for detecting visual impairment effectively.

Impact of outpatient management on the short-term outcome of very preterm infant with brocopulmonary dysplasia.

FENG Mei-mei,LIU Wang-kai,LI Xiao-yu,YU Mu-xue,ZHUANG Si-qi,LI Yi-juan.

2016, 24(8):  859-862.  DOI: 10.11852/zgetbjzz2016-24-08-22

Asbtract ( )   PDF (559KB) ( )  

References | Related Articles | Metrics

Objective To prospectively evaluate the impact of discharge management on the short-term outcome of very preterm infants with bronchopulmonary dysplasia (BPD). Methods The preterm infants who were admitted in Neonatal Intensive Care Unit of the first Affiliated Hospital of Sun Yat-Sen University from January 2013 to October 2014 were enrolled.Their gestational age was<32 weeks and all of them survived ≥28 d.The very preterm infants were divided into BPD group and non-BPD group.All the infants received follow up and early interventions.Their growth parameters,neurodevelopment events and respiratory symptoms were evaluated regularly after discharge. Results Totally 76 preterm infants were enrolled and the morbidity of BPD was 51.3%.There was no death and cerebral palsy among these very preterm infants.Their growths in weight and length between BPD and non-BPD groups had no significant differences(P ≥0.05),while their growth in head circumference of BPD group was slower than that of non-BPD group(P<0.05).The incidences of pneumonia,wheezing and re-hospitalization in BPD group were significantly higher than those of non-BPD group(P<0.05). Conclusions Discharge management could improve the short-term outcome of very preterm infants with BPD.It could promote their growth and neurodevelopment without decreasing the incidence of respiratory symptoms after discharge.

A case-control study of influencing factors of low birth weight in Chongqing.

LI Xue-mei,HE Dan,JIANG Qiu-jing,ZHOU Xiao-jun.

2016, 24(8):  863-866.  DOI: 10.11852/zgetbjzz2016-24-08-23

Asbtract ( )   PDF (506KB) ( )  

References | Related Articles | Metrics

Objective To explore the influence factors of low birth weight in Chongqing,and provide references to prevent and reduce the rate of low birth weight. Methods Case-control study method was implemented among 326 low birth weight infants and 326 normal infants from 6 maternal and child health care hospitals.A uniform questionnaire was used to investigate influencing factors,and conditional Logistic regression was used to analyze the data. Results Low birth weight was associate with mother's general information (BMI before pregnancy,education,average monthly income of family,etc.),condition during pregnancy(singleton pregnancy,antenatal care,gestational hypertension,etc.),living habit(smoking,drinking,passive smoking,etc.),and dietary(multivitamin tablets,meat,seafood,etc.).Multivariate analysis showed that average monthly income of family,singleton pregnancy,weight gain during pregnancy,and antenatal care had important protective effects on low birth weight.Meanwhile gestation complicated anemia was the main risk factor. Conclusion The occurrence of low birth weight is influenced by the various factors,so the comprehensive measures should be taken to control it.

Effect factors of birth weight of 642 neonates.

DANG Qun,ZHAO Zhi.

2016, 24(8):  867-869.  DOI: 10.11852/zgetbjzz2016-24-08-24

Asbtract ( )   PDF (416KB) ( )  

References | Related Articles | Metrics

Objective To explore the risk factors of birth weight,and to provide a proof for reducing the incidence of low birth weight infants and fetal macrosomia. Methods 642 cases born in Shaanxi Provincial People's Hospital were investigated retrospectively from January to May in 2015.Maternal general,previous reproductive history,living conditions during pregnancy and illness etc were collected.The risk factors of birth weight were analyzed by univariate analysis of variance and multivariate generalized linear regression analysis. Results Univariate analysis showed that the birth weight of low education,a history of spontaneous abortion and induced abortion,exposure to secondhand smoke during pregnancy,pregnancy sickness were lower (P<0.05),while the birth weight of infant whose mother supplement sufficient folic acid in pregnancy was higher (P<0.05).And the birth weight of boy was higher (P<0.05).Multivariate generalized linear regression analysis showed that the birth weight of exposure to secondhand smoke during pregnancy,a history of spontaneous abortion,pregnancy sickness were lower (β=-205.555,β=-210.675,β=-102.709,all P<0.05). Conclusions Birth weight is affected by many factors.Pregnant women should increase awareness of self-care during pregnancy,adopt a healthy lifestyle,strengthen nutrition,regular check-ups,and reduce the incidence of the disease during pregnancy.

Clinical analysis and follow up on 48 cases of benign convulsions associated with mild gastroenteritis.

LIU Yu,LI Dan,HUANG Shao-ping,YANG Lin.

2016, 24(8):  870-872.  DOI: 10.11852/zgetbjzz2016-24-08-25

Asbtract ( )   PDF (504KB) ( )  

References | Related Articles | Metrics

Objective To explore the clinical characteristics and prognosis in patients of benign convulsions associated with mild gastroenteritis(BICE). Methods The clinical manifestation of 48 patients were evaluated who hospitalized from January 2013 to February 2016,and then followed for 2~39 months. Results The age of onset was minimum 5 months,maximum 33 months respectively,the ratio of male to female was 5∶7.Convulsions occurred in 11 patients on the first day,9 patients on the second day and 28 patients on the third to seventh day.Convulsion occured in 34 cases for less than 5 minutes,14 cases for more than 5 minutes.In children with 48 cases,38 children had generalised seizures and 10 had partial seizures.The interctal EEG was abnormal in 15 patients.7 cases had family history of convulsion.7 cases had abnormal imaging examination.During the follow up,6 cases (12.50%)sufered from recurrence of seizure,5 of them had abnormal EEG and diagnosed as epilepsy. Conclusion Prognosis can have a good effect on patients with BICE,but a few have the risk of recurrence,the abnormal EEG might be the high risk factor,which is necessary for the children to follow up.

Correlation study between recurrent respiratory tract infections and immunoglobulin and IgG subclass in children.

TANG Xiu-ying,LI Li,XI Xiang-hong,SU Rong,ZHANG Yu-rong,LIAO Guo-ling.

2016, 24(8):  873-875.  DOI: 10.11852/zgetbjzz2016-24-08-26

Asbtract ( )   PDF (538KB) ( )  

References | Related Articles | Metrics

Objective To explore the correlation between recurrent respiratory tract infections(RRTI) and immunoglobulin and IgG subtypes in children. Methods According to diagnostic criteria of RRTI,80 cases of children group and 60 cases of control group of different age diagnosed with RRTI were collected from March 2014 to March 2015,and the levels of immunoglobulin (IgG,IgA,IgM)and IgG subtypes (G1,G2,G3,G4) in serum were detected. Results Compared with normal group:in 0 to 2 years old children group,the levels of IgG,IgA and IgM had no obvious differences (P>0.05),the level of IgG4 decreased significantly (P<0.05);In 3 to 5 years old children group,the levels of IgG and IgM had no significant differences (P>0.05),the level of IgA decreased obviously (P<0.05),the levels of IgG2 and IgG4 decreased significantly (P<0.05);In 6 to 12 years old children group,the levels of IgG,IgA and IgM had no obvious differences (P>0.05),the levels of IgG1,IgG2,IgG3 and IgG4 had no significant differences (P>0.05).And as children age,the levels of IgG and IgA had obvious growth trend,the level of IgM changed little.There were defects of IgG subtypes in children with RRTI,the detection rate of 42.5%,individual defects was given priority to with IgG4 accounted for 35%,joint defect was given priority to with IgG2 and IgG4 accounted for 41%. Conclusions There are defects of immunoglobulin IgG subtypes in RRTI of children.The class testing of IgG subtypes should be attached in clinical,the defects in IgG2 and IgG4 may be one of the causes of RRTI in children,which is more sensitive to reflect the immune function of children with RRTI.

Characteristic and trend of injury mortality among children aged 5~19 from 2008 to 2014 in Xi'an city.

ZHANG Xiao-yu,HOU Bin,ZHAO Guo-dong.

2016, 24(8):  876-879.  DOI: 10.11852/zgetbjzz2016-24-08-27

Asbtract ( )   PDF (573KB) ( )  

References | Related Articles | Metrics

Objective To understand the epidemiological characteristics and trend of injury mortality among children aged 5~19 from 2008 to 2014 in Xi'an city,and to provide evidence for making related interventions. Methods Data were derived from the disease death surveillance database during 2008 to 2014.ICD-10 was used to classify death causes.Mortality rate,proportional mortality indicator and annual percent change(APC) were calculated and analyzed. Results Mortality in injured deaths was 14.01/10⁵,which showed a descending tendency with the average decrease rate of 3.23%.The mortality in boys was higher than that in girls,and the mortality in boys showed a descending tendency(APC=-5.58%,t=-4.04,P<0.05).The first 5 kinds of injury death causes were traffic accidents,drowning,accidents,suicide and accidental poisoning,which accounted for 87.92% of total injury mortality among children aged 5 to 19 years old. Conclusions The injury mortality of children aged 5~19 years old showed a descending tendency.Traffic accidents and drowning are major causes of injury death.The damage prevention and control from family,school and social should be strengthened to reduce the injury mortality of young people.

Analysis of video electroencephalogram features in 60 children with cerebral palsy.

LI Yu-qin,LING Ya-ping,YU Ming.

2016, 24(8):  880-881.  DOI: 10.11852/zgetbjzz2016-24-08-28

Asbtract ( )   PDF (407KB) ( )  

References | Related Articles | Metrics

Objective To review the video electroencephalogram (VEEG) in children with cerebral palsy(CP),analyze the correlation between abnormal characteristics of VEEG and types of CP,and investigate the application value of VEEG. Methods The international 10/20 system electrode placement method was used to collect underwent VEEG examination of 60 cases of children with CP,including waking and sleep state,the results were analyzed retrospectively. Results Abnormal rate of VEEG in the 60 cases of children with CP was 76.67% (46/60).Abnormal rate of VEEG in children with spastic type of CP was the highest,up to 85.37% (35/41).The ratio of spastic CP complicated with epilepsy was 46.34% (19/41). Conclusion The abnormal rate of VEEG in children with CP is high.Abnormal characteristics of VEEG help to judge the location of lesion,determine whether complicated with epilepsy and seizure types,and reflect the functional status of nervous system.

Analysis of health care service and health condition for children under the age of seven of Karamay.

DONG Yue-lian,MAI Re-ye-mu-ni-sha,ZHU Fang.

2016, 24(8):  882-884.  DOI: 10.11852/zgetbjzz2016-24-08-29

Asbtract ( )   PDF (395KB) ( )  

References | Related Articles | Metrics

Objective To understand the status of the child care management of Karamay,further improve the quality of child care service and provide a scientific basis for health management decisions. Method Service index and health indicators of child health care from 2008 to 2015 of Karamay were analized. Results The proportion of health care coverage of children under the seven age from 2008 to 2015 of Karamay were 96.62%.The proportion of system management of children under the three age were 85.08%,neonatal visit rate was 91.04%,and breastfeeding rate of baby within six months was 78.80%,the exclusive breastfeeding rate was 34.73%;Incidence of low birth weight of children under the five age were 0.32%,the morbidity of moderately severe anemia was 0.73%. Conclusion Performance in child care work of Karamay raised significantly year by year in health care service.

Clinic significance of sFas/sFasL in serum of children with asthma.

FENG Jin-huan,WANG Meng-lan,ZHANG Jun-ying,WANG Xiao-jian.

2016, 24(8):  887-888.  DOI: 10.11852/zgetbjzz2016-24-08-31

Asbtract ( )   PDF (256KB) ( )  

References | Related Articles | Metrics

Objective To explore the clinic significance of sFas/sFasL in serum of children with asthma. Methods A total of 67 children with asthma (asthma group) and 40 healthy children (healthy control group) were selected,sFas,sFasL in their serums were detected by ABC-ELISA. Results Compared with healthy control group,the sFas and sFasL in serum of asthma group were elevated markedly(P<0.01). Conclusion The sFas,sFasL in children with asthma were higher than healthy children,sFas/ sFasL maybe take part in the pathological process of asthma.

Effects of low frequency electrical stimulation combined with acupuncture in the treatment on salivation in children with cerebral palsy.

ZHOU Tao-cheng,TONG Guang-lei,CHEN Lu-lu,ZHANG Yan-jiao.

2016, 24(8):  889-891.  DOI: 10.11852/zgetbjzz2016-24-08-32

Asbtract ( )   PDF (415KB) ( )  

References | Related Articles | Metrics

Objective To observe the clinical effect of using low frequency electric based on oral rehabilitation training on stimulation and acupuncture therapy in the treatment of children with cerebral palsy salivation. Methods 45 patients with salivation of children with cerebral palsy were randomly divided into observation group (23 cases) and control group (22 cases).The control group received oral rehabilitation training,while the observation group was treated with low frequency electric stimulation and acupuncture treatment on the basis of the control group.All the children were evaluated before and after treatment with teacher drooling sizing(TDS). Results The TDS of the observation group and the control group were significantly improved (P<0.05) after treatment.The observation group was better than the control group (U=2.97,P=0.03).The total effective rate was 91.30% and 63.64%,the difference between the two groups was statistically significant (χ²=6.63,P=0.04). Conclusion On the basis of oral rehabilitation training combined with low frequency electric stimulation combined with acupuncture therapy can significantly improve the symptoms of cerebral palsy dribbling,further improve the curative effect of rehabilitation.

Influencing factors of unintentional injury among children in rural areas of hunan province.

CHEN Si-si.

2016, 24(8):  892-894.  DOI: 10.11852/zgetbjzz2016-24-08-33

Asbtract ( )   PDF (423KB) ( )  

References | Related Articles | Metrics

Objective To analyze the influencing factors of unintentional injury among children in rural areas and provide scientific evidence to prevent and intervene unintentional injuries. Methods The study was carried out by random cluster stratified sampling method,1 601 children from a rural area of Hunan province were investigated with homemade injury questionnaire; SPSS 18.0 software was used to data analysis. Results 1 601 questionnaires were send out and 1 560 valid questionnaires were retrieved and the effective rate was 97.44%,653 unintentional injured children were screened out and the incidence of children unintentional injury in rural areas was 41.86%;Influencing factors analysis of accident proneness in rural children showed that children's gender,grade,only child or not,left-behind children or not,family economic status,education approaches,guardians' gender and health status were the main factors of it. Conclusion The incidence of children unintentional injury in rural areas is at a higher level,childrens' sociological demographic variables and guardians' related factors are influencing factors of it.