Objective To detect and analyse mumps virus antibody levels of 3 to 15 years old children and adolescents in High-tech Industrial Development Zone,Urumqi,and provide the basis for the formulation and adjustment mumps prevention and control strategies. Method By adopting the cluster sampling method,560 students aged 3 to 15 were select from six schools in High-tech Industrial Development Zone,Urumqi.The antibody of serum was detected by ELISA. Results The mumps virus antibody positive average rate was 78.92% in different age groups,the highest positive rate was found in the age group of 7~ and 14~15 up to 90%,the positive rate was decreased with the growth of age in the other groups,and was at its lowest in 5 to 12 years old; There was no significantly difference of mumps virus antibody positive rate in different gender and nation; Students of residence antibody positive rate was higher than shack students,and antibody positive rate was in proportion to the doses of vaccination. Conclusion Mumps virus antibody-positive rate in 3 to 15 years old students is lower in high-tech industrial development zone,Urumqi.The inoculating units should strengthen the management of floating children,improve the mumps vaccination rates in school-age children and succeed in doing preschool check verification and second dose of strengthening to prevent the disease outbreaks in our region.