Objective To explore the effect of perinatal high energy on lipid metabolism in SD rat offspring. Methods A total of 15 pregnant SD rats were divided randomly into control group,high fat group and high fat and high carbohydrate group,which were fed with lab chow,high fat diet(containing 20% of lard) and high fat and high carbohydrate diet(containing 20% of lard and 20% of sucrose) respectively.The pups of 4 weeks old were killed,and their body weight,the mass of liver and visceral fat and the levels of plasma TC,TG,HDL and leptin were determined. Results With aspects of body weight,the mass of liver and visceral fat,the data of high fat group(90.05±6.71),(3.73±0.18) and (0.41±0.12)g and high fat and high carbohydrate(89.82±5.08),(3.82±0.27) and (0.41±0.13)g were higher than those of control group(70.60±17.30),(2.87±0.83) and (0.22±0.07)g (P＜0.05);The level of plasma TC of high fat and high carbohydrate(1.72±0.10) was higher than that of high fat group(0.9±0.33) and control group(0.8±0.3)(P＜0.05);The levels of plasma TG of high fat group (0.83±0.54) and high fat and high carbohydrate group(1.02±0.22) were higer than that of control group(0.45±0.21)(P＜0.05);The level of plasma HDL and leptin of high fat group(0.23±0.08),(1.16±0.06) and high fat and high carbohydrate group(0.26±0.09),(1.15±0.04) were higher than those of control group(0.50±0.03),(1.26±0.08)(P＜0.05).Conclusion Perinatal high energy leads lipid dysfunction including obesity,disorder of plasma lipid,decline of plasma leptin and so on.