Objective To analyze the correlation of lipid metabolism with left ventricular hypertrophy (LVH) and left ventricular remodeling (LVR) in obese children, so as to provide reference for early clinical intervention of obese children. Methods A total of 86 cases of obese children who visited Affiliated Hospital of Jiangnan University from January 2018 to December 2021were enrolled in this study, meanwhile 80 cases of non-obese children were taken as the non-obese group in the same period. The levels of lipid metabolism indicators [including low density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), and high density lipoprotein (HDL)] and the incidence rates of LVH and LVR were compared between the two groups. The correlation of lipid metabolism with LVH and LVR was analyzed by Spearman correlation. The lipid metabolism indicators which could predict the risk of LVH and LVR were analyzed by a non-conditional Logistic regression model. Results The levels of LDL, TG and TC of children in obese group were significantly higher than those in non-obese group (t=5.604, 6.018, 5.273, P<0.001), while the level of HDL of children in obese group was significantly lower than that in non-obese group (t=6.437, P<0.001). The incidence rates of LVH and LVR in obese group was significantly higher than those in non-obese group (χ2=15.472, 13.079, P<0.001). The levels of LDL(r=0.506, 0.430), TG(r=0.547, 0.429) and TC(r=0.528, 0.475) were positively correlated with LVH and LVR (P<0.05 or <0.001), while thelevels of HDL were negatively correlated with LVH and LVR(r=-0.490, -0.411,P<0.05 or <0.01). Logistic regression analysis indicated that the levels of TG(OR=1.268, 1.183, 95%CI:1.107-1.468, 1.017-1.290), LDL(OR=1.280, 1.271, 95%CI:1.105-1.392, 1.136-1.385), HDL(OR=0.816, 0.847, 95%CI:0.705-0.987, 0.763-0.992)could predict the risk of LVH and LVR in obese children. Conclusion The lipid metabolism is correlated with LVH and LVR in obese children, and the lipid metabolism indicators are expected to be risk predictors of LVH and LVR in obese children
Key words
obesity /
lipid metabolism /
left ventricular hypertrophy /
left ventricular remodeling /
children
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 郑冬梅,梁学军,靳景璐,等.中国儿童肥胖的评估、治疗和预防指南[J].中国妇幼健康研究,2021,32(12):1716-1722.
Zheng DMi, Liang XJ, Jin JL, et al. Guidelines for the assessment, treatment and prevention of childhood obesity in China[J]. Chinese Journal of Woman and Child Health Research,2021,32(12):1716-1722.(in Chinese)
[2] 寇永妹,杨玉梅,陈新春,等.唐山地区青少年超重肥胖和血压偏高与左心室肥厚的关系[J].中国医师杂志,2020,22(9):1285-1289.
Kou YMi, Yang YM, Chen XC, et al. Relationship between overweight, obesity, high blood pressure and left ventricular hypertrophy in adolescents in Tangshan area[J]. J Chin Physician,2020,22(9):1285-1289.(in Chinese)
[3] Cuspidi C, Rescaldani M, Sala C, et al. Left-ventricular hypertrophy and obesity: A systematic review and meta-analysis of echocardiographic studies.[J]. J Hypertens, 2014, 32(1):16-25.
[4] 张云飞. 不同肥胖评价指标筛查儿童左心室肥厚和几何重构的效果比较[D].济南:山东大学,2021.
Zhang YF. Effect of different obesity evaluation indexes on screening left ventricular hypertrophy and geometric remodeling in children[D]. Jinan: Shandong University,2021.(in Chinese)
[5] 侯亚苹. 代谢异常指标聚集性与儿童左心室肥厚的关系[D].济南:山东大学,2019.
Hou YP. The relationship between the aggregation of metabolic abnormalities and left ventricular hypertrophy in children[D]. Jinan: Shandong University,2019.(in Chinese)
[6] 中国肥胖问题工作组.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):97-102.
China Working Group on Obesity. Weight index numerical classification criteria for screening overweight and obesity in school-age children and adolescents in China[J]. Chin J Epidemiol,2004,25(2):97-102.(in Chinese)
[7] 袁焕勤.超声心动图检查在高血压性左心室肥厚诊断中的应用价值[J].河南医学研究,2021,30(13):2470-2472.
Yuan HQ. Value of echocardiography in the diagnosis of hypertensive left ventricular hypertrophy[J]. J Henan Med Research,2021,30(13):2470-2472.(in Chinese)
[8] 肖培,程红,郁兆仓,等.基于体脂肪的肥胖评估指标在学龄儿童持续性血脂异常筛查中的应用[J].中华流行病学杂志,2020,41(12):2066-2071.
Xiao P, Cheng H, Yu ZC, et al. Application of obesity assessment index based on body fat in screening for persistent dyslipidemia in school-aged children[J]. Chin J Epidemiol,2020,41(12):2066-2071.(in Chinese)
[9] 郭腾,羊柳,张茜,等.儿童超重肥胖和血压偏高联合作用与左心室肥厚的关联研究[J].中华预防医学杂志,2019(7):686-691.
Guo T, Yang L, Zhang Q, et al. Relationship between left ventricular hypertrophy and obesity in children[J]. Chin J Preventive Medicine,2019(7):686-691.(in Chinese)
[10] 吴桂平,刘兆奕,林瑶瑶.儿童期肥胖与其成人高血压和左心室肥厚的相关性研究[J].河北医学,2022,(1):127-131.
Wu GP, Liu ZY, Lin YY. Study on the relationship between childhood obesity and adult hypertension and left ventricular hypertrophy[J]. Hebei Med,2022,(1):127-131.(in Chinese)
[11] Hanlon CE, Edem B, Garofano JS, et al. The association of obstructive sleep apnea and left ventricular hypertrophy in obese and overweight children with history of elevated blood pressure[J]. J Clin Hypertens, 2019,21(7):984-990.
[12] 解頔,陈文佳,尹新华.肥胖相关左心室肥厚的研究进展[J].心血管病学进展,2019,40(4):637-640.
Xie D, Chen WJ, Yin XH. Research progress of obesity-related left ventricular hypertrophy[J]. Progress in Cardiology,2019,40(4):637-640.(in Chinese)
[13] 张健,黄晓红.肥胖对心血管系统的影响研究进展[J].中国分子心脏病学杂志,2020,20(3):3417-3420.
Zhang J, Huang XH. Research progress of obesity on cardiovascular system[J]. Chin J Molecular Cardiology,2020,20(3):3417-3420.(in Chinese)
[14] 卜军,陈章炜,崔晓通,等.中国成人代谢异常与心血管疾病防治[J].上海医学,2020,43(3):129-164.
Bu J, Chen ZW, Cui XT, et al. Study on metabolic disorders and cardiovascular diseases in Chinese adults[J].Shanghai Med,2020,43(3):129-164.(in Chinese)
[15] 李若彤.血脂代谢与心血管的发生关系[J].泰山医学院学报,2014,35(2):154-156.
Li RT. The relationship between lipid metabolism and cardiovascular development[J]. Journal of Taishang Medical College,2014,35(2):154-156.(in Chinese)
[16] 杨鑫,胡炎伟.氧化低密度脂蛋白在动脉粥样硬化性心血管疾病诊断中的作用[J].中华检验医学杂志,2021,44(7):563-568.
Yang X, Hu YW. Role of oxidized low-density lipoprotein in the diagnosis of atherosclerotic cardiovascular disease[J]. Chin J Lab Med,2021,44(7):563-568.(in Chinese)
[17] 朱玉芳,李康,郝冉,等.脂肪细胞型脂肪酸结合蛋白在心血管疾病中的作用[J].中国老年学杂志,2022,42(1):244-248.
Zhu YF, Li K, Hao R, et al.Role of adipocytic fatty acid binding protein in cardiovascular disease[J].Chin J Gerontology, 222,42(1):244-248.(in Chinese)
[18] 王鉴,王華麟,杜博文,等.4岁儿童体重状态与早期血压、心脏结构功能改变的研究[J].中华儿科杂志,2022,60(6):551-556.
Wang J, Wang HL, Du BW, et al. Weight status and early blood pressure, cardiac structure and function changes in 4-year-old children[J]. Chin J Pediatrics, 222,60(6):551-556.(in Chinese)
[19] 彭颖静,刘丽敏,姚健,等.线粒体ATP敏感性钾离子通道开放剂对大鼠冠状动脉硬化斑块及血脂代谢的影响[J].重庆医学,2022,51(9):1441-1447.
Peng YJ, Liu LM, Yao J, et al. Effects of mitochondrial ATP-sensitive potassium channel openers on atherosclerotic plaque and lipid metabolism in rats[J]. Chongqing Med,202,51(9):1441-1447.(in Chinese)
[20] 邹小艳,范香成,田友清,等.木樨草素等抗心肌缺血/再灌注损伤及抑制脂代谢和细胞凋亡作用研究[J].南京中医药大学学报,2020,36(3):380-386.
Zou XY, Fan XC, Tian YQ, et al. Effects of luteolin on myocardial ischemia/reperfusion injury, lipid metabolism and apoptosis[J].J Nanjing Univ TCM,2020,36(3):380-386.(in Chinese)
PDF(483 KB)
