Relationship between MP-IgG and lipid metabolism in children

YAN Sangsang; ZHANG Jingxia; XU Meimei; WANG Guizhi; ZHU Tang; HAN Lihong

doi:10.11852/zgetbjzz2022-0606

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (8) : 904-908. DOI: 10.11852/zgetbjzz2022-0606

Relationship between MP-IgG and lipid metabolism in children

YAN Sangsang¹, ZHANG Jingxia¹, XU Meimei², WANG Guizhi³, ZHU Tang¹, HAN Lihong¹

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Abstract

Objective To investigate the relationship between Mycoplasma pneumonia (MP) infection and hyperlipidemia in children, in order to provide better guidance for the prevention and treatment of MP infection in children. Methods Serum specimens were collected from 472 children who took routine physical examinations in pediatric outpatient clinic from October 2020 to January 2021.MP-IgG and lipid metabolism indicators, including triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), apolipoprotein Protein B (ApoB), was detected separately. Results The levels of TC and LDL-C in theMP-IgG positivegroup were higher than those in the MP-IgG negative group (Z=-2.746,-2.510, P＜0.05).The proportion of hypercholesterolemia in the MP-IgG positive group was significantly higher than that in theMP-IgG negative group (χ²=5.984, P=0.014).There was a statistically linear trend, also named a dose-response relationship, between MP-IgG grades and TC grades/LDL-C grades (χ²=12.704, 9.731, P＜0.05).Both Spearman correlation test and Kendall'tau b correlation test showed that MP-IgG was positively correlated with TC and LDL-C(P<0.05).Multi-class Logistic regression analysis showed that hypercholesterolemia may be an important factor affecting MP infection in children.The probability of MP-IgG positive in children with hypercholesterolemia was 2.865(95%CI:1.202 - 6.832) times that in children with normal TC. Conclusions There is a correlation between MP infection in children and hyperlipidemia.Appropriately reduction in cholesterol level may be beneficial to prevent and treat MP infection in children.

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mycoplasma pneumoniae / infection / lipid metabolism / hypercholesterolemia / children

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YAN Sangsang, ZHANG Jingxia, XU Meimei, WANG Guizhi, ZHU Tang, HAN Lihong. Relationship between MP-IgG and lipid metabolism in children[J]. Chinese Journal of Child Health Care. 2023, 31(8): 904-908 https://doi.org/10.11852/zgetbjzz2022-0606

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