Abstract: Objective To study the association of serum irisin level with endocrine and metabolic parameters in obese children,in order to provide reference for clinicd practice. Methods Data of 89 children treated in Linyi People's Hospital from May 2022 to May 2023 were retrospectively analyzed.According to body mass index (BMI), children were divided into obesity group (n=48) and normal control group (n=41).Multiple linear regression analysis was used to analyze the related factors of serum irisin and endocrine metabolism indexes. Results The levels of serum irisin, free triiodothyronine (FT3), free triiodothyronine/free thyroxine (FT3/FT4), thyroid stimulating hormone (TSH),adrenocoriticotropbic hormone(ACTH), triglyceride (TG), C-peptide, insulin, insulin resistance index (HOMA-IR)in obese children were significantly higher than those of the control group (t/Z=2.120, 2.836, 2.403, 2.325, 2.099, 5.870, 7.186, 7.120, 7.103, P<0.05), while high-density lipoproteinwas significantly lower than that in the control group (t=4.084, P<0.05).It was found that serum irisin level was positively correlated with TG (r=0.390, P=0.006) and negatively correlated with FT3 (r=-0.311, P=0.032).Multiple linear regression analysis showed that FT3 (β=-0.468) and TG (β=0.599) were the main factors influencing serum irisin levels in obese children. Conclusion Obese children have a high serum irisin level, and irisin is associated with lipid metabolism and thyroid function.

Key words: serum irisin, thyroid function, obese children, glucose and lipid metabolism

摘要： 目的 探索肥胖儿童的血清鸢尾素水平和内分泌代谢指标的关系,为临床实践提供参考资料。方法 选取2022年5月—2023年5月临沂市人民医院门诊行健康查体的89名儿童,依据体质量指数(BMI)分为肥胖组48例和正常对照组41例,测量体量指标、检测血清鸢尾素及相关内分泌代谢参数。采用多元线性回归分析影响肥胖儿童血清鸢尾素水平的内分泌代谢指标的相关因素。结果 肥胖组儿童血清鸢尾素、游离三碘甲状腺原氨酸(FT3)、游离三碘甲状腺原氨酸/游离甲状腺素(FT3/FT4)、促甲状腺激素(TSH)、促肾上腺皮质激素(ACTH)、甘油三脂(TG)、C肽、胰岛素、胰岛素抵抗指数(HOMA-IR)均高于对照组(t/Z＝2.120、2.836、2.403、2.325、2.099、5.870、7.186、7.120、7.103),高密度脂蛋白(HDL-C)低于对照组(t＝4.084),差异均有统计学意义(P＜0.05)。肥胖儿童血清鸢尾素与TG呈正相关(r＝0.390,P＝0.006),与FT3呈负相关(r=-0.311,P=0.032)。多元线性回归分析发现FT3(β=-0.468)、TG(β=0.599)是肥胖儿童血清鸢尾素水平的主要影响因素(P<0.05)。结论 肥胖儿童血清鸢尾素水平高,与脂质代谢及甲状腺功能存在相关性。

关键词: 血清鸢尾素, 甲状腺功能, 肥胖儿童, 糖脂代谢