Objective To study the efficacy of comprehensive intervention on the autistic children. Methods After 60 cases (boys 51,girls 9,aged from 1.5 to 6.5) with autism according to the DSM-IV were assessed,individual convention plan was made.The plan,emphasizing family involvement,was applied in training,including Applied Behavior Analysis (ABA),Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) and Relationship Development Intervention (RDI).The scores of Autism Treatment Evaluation Checklist (ATEC) and Infant-Junior Middle school Social Adaptive Capacity Scale (SM)were investigated before and after training. Results The ATEC total score of 60 autistic children was significantly decreased from 79.83±16.98 to 46.82±6.95(P<0.01).The subscale scores including language,social intercourse,sensory and behavior were decreased(P<0.01),and the score of less than 3 years of age group was better than that of greater than 3 years group,and the difference was significant(P<0.01).The SM score was increased from 7.43±1.16 to 8.87±1.06,and the score of less than 3 years of age group was better than that of greater than 3 years group too,and the difference was significant(P<0.01). Conclusion The training strategy of comprehensive intervention in a certain extent could alleviate the symptoms of autism and improve its ability to adapt the society.