Abstract: 【Objective】 To investigate the anti-HBs(hepatitis B virus surface antibody) level of children entering nurseries or kindergartens in Ningbo city after basic hepatitis B vaccination. 【Methods】 466 children in Ningbo city entering nurseries or kindergartens who had finished 3 times basic hepatitis B vaccination were enrolled the study by using the method of random sampling and their HBsAg(hepatitis B virus surface antigen) and anti-HBs levels were detected. 【Results】 The average rate of HBsAg carring and high anti-HBs level were 0 and 30.69%;The incidence of high anti-HBs level in groups aged 1.5~2,3,above 4 were 35.42%,29.24% and 15.79%;The incidence of high anti-HBs level in groups vaccination during the first month and surpass one month after birth were 27.25% and 55.56%. 【Conclusions】 The anti-HBs level of children entering nurseries or kindergartens is low,and it is dropped with the increase of ages.A supplementary immunization was proposed to the low or no anti-HBs level healthy child.

Key words: hepatitis B vaccination, anti-HBs level, children

摘要： 【目的】 了解宁波市区完成基础免疫儿童乙肝抗体水平。 【方法】 采用随机整群抽样的方法抽取宁波市江东区进行过三剂次乙肝基础免疫的466名入托入园儿童进行HBsAg和抗-HBs水平检测。 【结果】 未检测出乙肝病毒表面抗原阳性儿童,乙肝高抗体检出率为30.69%;1.5~2岁组、3岁和4岁以上组儿童高抗体检出率分别为35.42%、29.24%和15.79%;接种时间在出生后1个月内和1个月后的儿童高抗体检出率分别为27.25%和55.56%。 【结论】 入托入园儿童乙肝高抗体检出率较低,且随年龄的增加而降低,建议对低抗体或未检出抗体的健康儿童进行乙肝加强免疫。

关键词: 乙肝疫苗, 抗体水平, 儿童