Abstract: 【Objective】 To investigate the auditory sensory memory function of normal preschool children with auditory event-related potential. 【Methods】 The mismatch negativity(MMN)was obtained in preschool children ages ranged from 30 to 72 months in an oddball paradigm.Stimulus consisted of 1 000 Hz tones with 85% probability as standard and 1 200 Hz with 15% probability as deviant. 【Results】 Pure tones elicited a strong MMN(peaking at about 170~175 ms)and a late discrimination negativity(peaking at about 450~500 ms)after stimulus onset mainly in the frontocentral area.There was no significant difference between the right and left hemisphere in the mean amplitude of 100 to 250 ms time-window. 【Conclusions】 The MMN and late discrimination negativity are developmentally quite stable in preschool children.There are probably difference in auditory sensory memory processing between male and female preschool children.

Key words: event-related potential, mismatch negativity, child, preschool, auditory sensory memory

摘要： 【目的】 使用听觉事件相关电位研究正常学龄前儿童的听觉感觉记忆功能。 【方法】 使用听觉oddball范式对30~72个月正常学龄前儿童给予纯音刺激,标准刺激和偏离刺激分别为1 000 Hz和1 200 Hz,二者出现概率分别为0.85和0.15。 【结果】 正常学龄前儿童出现明确的失匹配负波和晚辨别负波,主要分布在额中央区,平均潜伏期在170~175 ms 和450~500 ms。左右半球在100~250 ms时间窗内失匹配负波平均振幅未见显著差异。在F4点男性儿童较女性儿童振幅显著增高。 【结论】 学龄前儿童具有发育稳定的失匹配负波和晚辨别负波。男女性可能在学龄前期存在听觉感觉记忆加工差别。

关键词: 事件相关电位, 失匹配负波, 儿童, 学龄前, 听觉感觉记忆