Advances in understanding epigenetic motor regulation mechanisms in early childhood development

ZHANG Ting

Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (8) : 821-825.

PDF(1195 KB)
PDF(1195 KB)
Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (8) : 821-825. DOI: 10.11852/zgetbjzz2024-0840
Professional Forum

Advances in understanding epigenetic motor regulation mechanisms in early childhood development

  • ZHANG Ting
Author information +
History +

Abstract

The health quality of early childhood development is closely related to the balanced diet and active physical activity in children's daily life. With the progress of life science research, the scientific comprehension of this interrelation becomes increasingly profound. Therefore, under the premise of a nutritionally balanced diet for children, this paper describes the influence of body movement on the epigenetic modification of the body. The orderly regulation of downstream functional genes plays a supporting role in the homeostasis of cell communication and tissue communication in the body, so as to ensure the good development of children's bodies. Among them, the mechanism of exercise epigenetics, including DNA methylation, histone modification, non-histone modification, epigenetic modification reader, exercise lactate metabolism and lactoacylation modification and other research progress are introduced, and the molecular basis of children's scientific physical activity is systematically clarified.

Key words

epigenetics / physical activity / early childhood development

Cite this article

Download Citations
ZHANG Ting. Advances in understanding epigenetic motor regulation mechanisms in early childhood development[J]. Chinese Journal of Child Health Care. 2024, 32(8): 821-825 https://doi.org/10.11852/zgetbjzz2024-0840

References

[1] Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: Definitions and distinctions for health-related research[J]. Public Health Rep, 1985, 100(2): 126-131.
[2] Mendes MA, da Silva I, Ramires V, et al. Metabolic equivalent of task (METs) thresholds as an indicator of physical activity intensity[J]. PLoS One, 2018, 13(7): e0200701.
[3] 王健.身体活动与学龄前儿童早期发展[J].中国儿童保健杂志,2022,30(6):585-590.
Wang J.Physical activity and early childhood development of preschool children[J]. Chin J Child Health Care,2022,30(6):585-590.(in Chinese)
[4] Zeng N, Ayyub M, Sun H, et al. Effects of physical activity on motor skills and cognitive development in early childhood: A systematic review[J]. Biomed Res Int,2017,2017:2760716.
[5] St Laurent CW, Burkart S, Andre C,et al. Physical activity, fitness, school readiness, and cognition in early childhood: A systematic review[J]. J Phys Act Health,2021,18(8):1004-1013.
[6] Bangsbo J, Krustrup P, Duda J.et al. The copenhagen consensus conference 2016: Children, youth, and physical activity in schools and during leisure time[J]. Br J Sports Med, 2016, 50(19):1177-1178.
[7] National Scientific Council on the Development of the Child, 2010. Early experiences can alter gene expression and affect long-term development [R]. Opens in a new window Working Paper No. 10.Boston:Harvard University.
[8] Zhu H, Wang GH, Qian J . Transcription factors as readers and effectors of DNA methylation[J]. Nat Rev Genet, 2016,17(9):551-565.
[9] Tsai CH, Liao Y,Chang SH. Cross-sectional association of physical activity levels with risks of sarcopenia among older Taiwanese adults[J].BMC Geriatr.2024,24(1):560-571.
[10] Gomez-Pinilla F, Zhuang Y, Feng J. Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation[J]. Eur J Neurosci, 2011,33(3):383-390.
[11] Sølvsten CA, Paoli FD, Christensen JH, et al. Voluntary physical exercise induces expression and epigenetic remodeling of VegfA in the rat hippocampus[J]. Mol Neurobiol, 2018, 55(1):567-582.
[12] Voisin S, Eynon N. Yan X, et al. Exercise training and DNA methylation in humans[J]. Acta Physiol (Oxf), 2015, 213(1):39-59.
[13] McGee SL, Walder KR. Exercise and the skeletal muscle epigenome[J]. Cold Spring Harb Perspect Med, 2017, 7:a029876.
[14] Petrosino JM, Hinger SA, Golubeva VA, et al. The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice[J]. Nat Commun, 2022,13(1):168.
[15] Yan L, Wei JA, Yang F, et al. Physical exercise prevented stress-induced anxiety via improving brain RNA methylation[J]. Adv Sci, 2022,9(24):e2105731.
[16] Kouzarides T. Chromatin modifications and their function[J]. Cell, 128 (4): 693-705.
[17] Smith JA, Kohn TA, Chetty AK, et al. CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene[J]. Am J Physiol Endocrinol Metab,2008, 295 (3): e698- e704.
[18] Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications[J]. Cell Res,2011, 21(3): 381-395.
[19] RMurphy RM, Watt MJ, Febbraio MA. Metabolic communication during exercise[J]. Nat Metab, 2020,2(9):805-816.
[20] Fletcher, WM. Lactic acid in amphibian muscle[J]. J Physiol,1907, 35 (4): 247-309.
[21] Schurr A. Cerebral glycolysis: A century of persistent misunderstanding and misconception[J]. Front Neurosci, 2014, 19 (8): 360.
[22] Zhang D, Tang Z, Huang H, et al. Metabolic regulation of gene expression by histone lactylation[J]. Nature, 2019, 574(7779):575-580.
[23] Brooks GA, Arevalo JA, Osmond AD, et al. Lactate in contemporary biology: A phoenix risen[J]. J Physiol, 2022, 600(5):1229-1251.
[24] Pan RY, He L, Zhang J, et al. Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease[J]. Cell Metab, 2022, 34(4):634-648.e6.
[25] Han H, Zhao YW, Du JD, et al.Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia[J]. Immun Ageing, 2023,20(1):63.
[26] Desgeorges T, Galle E, Zhang J, et al. Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration[J]. MolMetab, 2024, 83:101923.
[27] Lin J, Wu Y, Tian G, et al. Menin "reads" H3K79me2 mark in a nucleosomal context[J]. Science, 2023,379(6633):717-723.
[28] Huang H, Zhang D, Wang Y, et al. Lysine benzoylation is a histone mark regulated by SIRT2[J]. Nat Commun, 2018, 9(1):3374.
[29] Li Y, Sabari BR, Panchenko T, et al. Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain[J]. Mol Cell, 2016, 62(2):181-193.
[30] Mao YZ, Zhang JJ, Zhou Q, et al.Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation[J]. Cell Res, 2024,34(1):13-30.
[31] Zhang MG, Jia JF, Yang Y, et al.Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis[J]. Ageing Res Rev, 2023,92:102116.
PDF(1195 KB)

Accesses

Citation

Detail

Sections
Recommended

/