Abstract: 【Objective】 To investigate the epidemiological characteristics of the children infected with rotavirus in Hangzhou,and to provide evidence to prevent and cure the children with acute diarrhea caused by rotavirus infection. 【Method】 The antigen assay of rotavirus in stool from the outpatient and inpatient children with acute diarrhea was employed in 2007-2011,and the positive patient information was statistically analyzed. 【Results】 The rotavirus-positive rate of the children of Hangzhou was 29.25% in 2007-2011,the annual rotavirus-positive rate decreased from 39.42% in 2007 to 19.61% in 2011.The epidemic period of children rotavirus was mainly in November and December of every year,and the children aged 6~18 months had the high infection rate.The rotavirus-positive rate was 32.28% in outpatient children with diarrhea,and the positive rate was 20.70% in hospitalized children. 【Conclusion】 The children rotavirus infection rate was lower than the national average level in Hangzhou,the safe and effective rotavirus vaccine development may eradicate the hazards of children rotavirus in the prevention and treatment of children rotavirus.

Key words: diarrhea, rotavirus, epidemiology, children

摘要： 【目的】 探讨杭州地区腹泻儿童感染A组轮状病毒的流行病学特征,指导临床防治。 【方法】 对2007-2011年门诊和住院的急性腹泻儿童的大便进行轮状病毒抗原检测,并采用统计方法分析流行病学特征。 【结果】 杭州地区2007-2011年腹泻儿童A组轮状病毒平均阳性率为29.25%。阳性率从2007年的39.42%下降到2011年的19.61%,其中每年11-12月份为儿童轮状病毒感染高峰期;且以6~18月的患儿感染率最高。腹泻儿童中门诊轮状病毒阳性率为32.28%,住院儿童的阳性率为20.70%。 【结论】 杭州地区儿童A组轮状病毒感染率低于全国平均水平,而且有逐年下降趋势。在今后应加快安全高效的轮状病毒疫苗的开发,从根本上解决儿童轮状病毒的危害。

关键词: 腹泻, 轮状病毒, 流行病学, 儿童