Study on intravenous amino acid administration to late preterm infants directly after birth

KONG Xiang-yong; LIU Jing; KONG Ling-kai; ZHOU Wei-qin; ZHENG Yang; CHI Jing-han; LI Li-hua; SHANG Ming-xia; FENG Zhi-chun

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Chinese Journal of Child Health Care ›› 2011, Vol. 19 ›› Issue (9) : 786-788.

Study on intravenous amino acid administration to late preterm infants directly after birth

KONG Xiang-yong, LIU Jing, KONG Ling-kai, ZHOU Wei-qin, ZHENG Yang, CHI Jing-han, LI Li-hua, SHANG Ming-xia, FENG Zhi-chun

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Abstract

【Objective】 To test the hypothesis that the early administration of amino acids (AA) 2.4 g/(kg·d) to late preterm infants is safe and resultful in a positive nitrogen balance. 【Methods】 A randomized and clinical trial was conducted. Preterm infants with gestational ages between 34W to 36⁺⁶W received either glucose and AA 2.4 g/(kg·d) from birth onward (within 2 hours after birth) (n=56) or solely glucose during the first day with a stepwise increase in AA intake to AA 2.4 g/(kg·d) on days 3 (n=59). Blood gas analysis was performed at admission and in the 2^nd, 4^th postnatal days; blood urea nitrogen levels were determined on the 2^nd day and the 4^thday after birth; nitrogen balances were determined on the 2^nd day and the 4^thday after birth. 【Results】 Modestly altered blood gas values (BE and Bicarbonate) and increased BUN levels with early AA administration in intervention group compared with those in control group (P<0.05 or <0.01 respectively). The infants in the control group had higher glucose level than those in the intervention group at the second day after birth (P<0.05). Nitrogen balance was higher in the intervention group on the 2^nd day after birth as compared with the control group, which had a negative nitrogen balance (P<0.05). 【Conclusions】 High-dose AA administration to late preterm infants can be introduced safely from birth onward and resultful in an anabolic state.

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late-preterm infants / high-dose amino acid administration / early

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KONG Xiang-yong, LIU Jing, KONG Ling-kai, ZHOU Wei-qin, ZHENG Yang, CHI Jing-han, LI Li-hua, SHANG Ming-xia, FENG Zhi-chun. Study on intravenous amino acid administration to late preterm infants directly after birth[J]. Chinese Journal of Child Health Care. 2011, 19(9): 786-788

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