Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers

GAN Kaiyan; HUANG Anqi; ZHANG Ziyi; GUAN Luyang; WANG Fei; KE Xiaoyan

doi:10.11852/zgetbjzz2023-1260

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Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (10) : 1076-1079. DOI: 10.11852/zgetbjzz2023-1260

Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers

GAN Kaiyan¹, HUANG Anqi^1,2, ZHANG Ziyi¹, GUAN Luyang¹, WANG Fei¹, KE Xiaoyan^1,2

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Abstract

Objective To analyze the consistency between the early screening Results of the Modified Checklist for Autism in Toddlers (M-CHAT) for infants and toddlers suspected of having autism spectrum disorder (ASD) and their subsequent clinical diagnosis, in order to provide reference for clinical practice and improve the early identification rate of ASD. Methods Infants and toddlers aged 16 to 30 months who first visited the Child Mental Health Research Center of Nanjing Brain Hospital between January 1st, 2017, and January 1st, 2021, were enrolled in the study. General data were collected and comprehensive assessments were completed at baseline. Between April and September 2023, telephone follow-ups were conducted to ascertain the diagnostic status of the children. The consistency between the M-CHAT screening outcomes for high-risk ASD children under 30 months and their later diagnostic follow-ups was analyzed. Results The M-CHAT showed a sensitivity of 0.937, specificity of 0.514, positive predictive value (PPV) of 0.929, negative predictive value (NPV) of 0.545, and an area under the curve (AUC) of 0.726. No statistically significant difference in the positive screening rate was observed between the two age groups of 16 - 23 months and 24 - 30 months old (83.8% vs.90.6%,χ²=2.824,P=0.113). Conclusion The M-CHAT demonstrates good screening efficacy in the early detection of ASD and exhibits a favorable diagnostic stability.

Key words

autism spectrum disorder / early screening / early diagnosis / Modified Checklist For Autism in Toddlers / diagnostic stability

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GAN Kaiyan, HUANG Anqi, ZHANG Ziyi, GUAN Luyang, WANG Fei, KE Xiaoyan. Prospective study of the stability of early diagnosis of autism spectrum disorder with positive screening results of Modified Checklist for Autism in Toddlers[J]. Chinese Journal of Child Health Care. 2024, 32(10): 1076-1079 https://doi.org/10.11852/zgetbjzz2023-1260

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