【Objective】 To evaluate the association of a history of respiratory infection in the first few months after neonatal birth with current asthma in locality. 【Methods】 A total of 301 children with average aged 4 years were recruited into study group and 301 children without asthma were categorized into control group. The parents of these children were responded to a questionnaire covering demographic factors, lifestyle, home environment, and health history, including a detailed history of respiratory conditions. Logistic regression was used to model the association of asthma and asthma severity with history of respiratory infections, controlling for gender, family history of asthma, and other factors. 【Results】 Our data indicated the significant association of current asthma with the numbers of respiratory infection and ear infection in the past year and the morbidity of bronchiolitis, pneumonia, bronchitis, NICU treatment in neonate, male, asthmatic family history, allergies and passive smoking, but not with the first age at first respiratory and ear infection. 【Conclusion】 There is association of early respiratory and ear infection with children's current asthma in locality, and more attention about the prevention of asthma must be paid for children with high risk factors of early infection disease.