Advances in potential mechanisms of non-invasive electrical vagus nerve  stimulation in the treatment of attention-deficit/hyperactivity disorder

doi:10.11852/zgetbjzz2024-0605

Abstract

Abstract: The vagus nerve (VN) originates from the brainstem, serving as a bidirectional communication bridge between the brain and the body, and is widely distributed throughout the central and peripheral nervous systems. Noninvasive vagus nerve stimulation (nVNS) is a neuromodulation technique with active regulatory functions that has been applied in the treatment of various diseases in recent years, demonstrating significant effects in conditions such as depression and epilepsy. However, there have been relatively few studies on its use in the treatment of attention deficit hyperactivity disorder (ADHD). By summarizing the pathogenesis of ADHD and the mechanism of nVNS, this article identifies associations between the two in terms of neurotransmitters, inflammation, apoptosis, and other aspects, and explore the potential mechanisms that exist between them, so as to provide a theoretical foundation for nVNS treatment of ADHD.

Key words: non-invasive, vagus nerve stimulation, attention-deficit/hyperactivity disorder

摘要： 迷走神经(VN)起自脑干,在脑-体间建立了双向沟通的桥梁,广泛分布于中枢和周围神经系统。非侵入性迷走神经刺激(nVNS)是一种具有主动调控功能的神经调控手段,近年来已经被应用于许多疾病的治疗,例如在抑郁、癫痫等疾病中发挥着显著作用,但在治疗注意缺陷多动障碍(ADHD)的相关研究较少,本文通过对ADHD发病机制、nVNS作用机制的总结,发现两者在神经递质、炎症以及凋亡等方面存在着关联,探寻两者之间存在的潜在机制,以期为nVNS治疗ADHD奠定理论基础与治疗的思路。

关键词: 非侵入性, 迷走神经电刺激, 注意缺陷多动障碍

CLC Number:

R179

XU He, ZHI Jincao, CHANG Qing, WANG Yan. Advances in potential mechanisms of non-invasive electrical vagus nerve stimulation in the treatment of attention-deficit/hyperactivity disorder[J]. Chinese Journal of Child Health Care, 2025, 33(8): 883-887.

徐河, 支金草, 常庆, 王艳. 非侵入性迷走神经电刺激治疗注意缺陷多动障碍的潜在机制研究进展[J]. 中国儿童保健杂志, 2025, 33(8): 883-887.

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Advances in potential mechanisms of non-invasive electrical vagus nerve stimulation in the treatment of attention-deficit/hyperactivity disorder

非侵入性迷走神经电刺激治疗注意缺陷多动障碍的潜在机制研究进展

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