Correlation between overweight or obesity and common neurodevelopmental disorders in children

doi:10.11852/zgetbjzz2024-0344

Abstract

Abstract: With the escalating prevalence of obesity,it has emerged as a significant public health concern affecting children and adolescents both physically and mentally.There is growing evidence indicating a substantial co-occurrence of overweight and obesity alongside neurodevelopmental disorders,notably attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).This paper reviews the literature exploring the correlation between childhood overweight,obesity,and prevalent neurodevelopmental disorders,with the aim of enhancing clinicians′ recognition of overweight or obesity in children diagnosed with neurodevelopmental disorders,thereby furnishing a foundation for integrated management strategies for these common conditions.

Key words: overweight, obesity, children, neurodevelopmental disorders

摘要： 随着肥胖患病率的逐年增加,肥胖已成为影响儿童和青少年身心健康的重要公共卫生问题。越来越多的文献证据表明,超重、肥胖与注意缺陷多动障碍、孤独症谱系障碍等神经发育障碍具有较高的共患率。本文综述了儿童超重、肥胖与常见神经发育障碍相关性的文献,旨在提高临床医生对神经发育障碍患儿中超重或肥胖的识别,为常见神经发育障碍的综合管理提供依据。

关键词: 超重, 肥胖, 儿童, 神经发育障碍

CLC Number:

R723.14

WANG Xifei, XUE Yang, JIA Feiyong, LI Honghua. Correlation between overweight or obesity and common neurodevelopmental disorders in children[J]. Chinese Journal of Child Health Care, 2025, 33(2): 191-195.

王熙扉, 薛洋, 贾飞勇, 李洪华. 儿童超重肥胖与常见神经发育障碍的相关性研究进展[J]. 中国儿童保健杂志, 2025, 33(2): 191-195.

References

[1] 中华医学会儿科学分会内分泌遗传代谢学组,中华医学会儿科学分会儿童保健学组,中华医学会儿科学分会临床营养学组,等.中国儿童肥胖诊断评估与管理专家共识[J].中华儿科杂志,2022,(6):507-515.
The Subspecialty Group of Endocrinologic,Hereditary and Metabolic Diseases,The Society of Pediatrics,Chinese Medical Association,The Subspecialty Group of Child Health Care,The Society of Pediatrics,Chinese Medical Association,The Subspecialty Group of Clinical Nutrition,The Society of Pediarics,Chinese Medical Association,et al.Expert consensus on diagnosis,assessment,and management of obesity in Chinese children[J].Chin J Pediatr,2022,(06):507-515.(in Chinese)
[2] Collaboration NCDRF.Worldwide trends in body-mass index,underweight,overweight,and obesity from 1975 to 2016:A pooled analysis of 2 416 population-based measurement studies in 128.9 million children,adolescents,and adults[J].Lancet,2017,390(10113):2627-2642.
[3] 胡霄,李丽,欧阳一非,等.2000—2018年中国十六省(自治区、直辖市)7～17岁儿童青少年超重与肥胖流行趋势[J].卫生研究,2022,51(4):568-573.
Hu X,Li L,Ouyang YF,et al.Trends of overweight and obesity among children and adolescents aged 7-17 in 16 provinces of China from 2000 to 2018[J].J Hyg Res,2022,51(4):568-573.(in Chinese)
[4] American Psychiatric Association.Diagnostic and statisticalmanual of mental disorders:DSM-5[M].5th ed.Washington DC:American Psychiatric Association,2013.
[5] Wentz E,Bjork A,Dahlgren J.Neurodevelopmental disorders are highly over-represented in children with obesity:A cross-sectional study[J].Obesity (Silver Spring),2017,25(1):178-184.
[6] Li YJ,Xie XN,Lei X,et al.Global prevalence of obesity,overweight and underweight in children,adolescents and adults with autism spectrum disorder,attention-deficit hyperactivity disorder:A systematic review and meta-analysis[J].Obes Rev,2020,21(12):e13123.
[7] Zhang S,Huang Y,Zaid M,et al.ADHD symptoms and obesity in Chinese children and adolescents:A longitudinal study with abnormal eating behaviors as moderating factors[J].J Atten Disord,2022,26(11):1452-1463.
[8] Hughes AM,Sanderson E,Morris T,et al.Body mass index and childhood symptoms of depression,anxiety,and attention-deficit hyperactivity disorder:A within-family mendelian randomization study[J].Elife,2022,11:e74320.
[9] Turkoglu S,Bilgic A,Akca OF.ADHD symptoms,breast-feeding and obesity in children and adolescents[J].Pediatr Int,2015,57(4):546-551.
[10] Ben Amor L,Lachal J.Impulsivity and obesity in children with attention deficit hyperactivity disorder:A clinical,neuropsychological and magnetic resonance spectroscopy exploratory study[J].Encephale,2019,45(6):494-500.
[11] 刘芮卓,陈立.儿童注意缺陷多动障碍与肥胖的相关性研究[J].中国儿童保健杂志,2023,31(4):412-415.
Liu RZ,Chen L.Research progress in the correlation between attention-deficit hyperactivity disorder and obesity in children[J].Chin J Child Health Care,2023,31(4):412-415.(in Chinese)
[12] O′Hara VM,Curran JL,Browne NT.The co-occurrence of pediatric obesity and ADHD:An understanding of shared pathophysiology and implications for collaborative management[J].Curr Obes Rep,2020,9(4):451-461.
[13] Wentz E,Bjork A,Dahlgren J.Is there an overlap between eating disorders and neurodevelopmental disorders in children with obesity?[J].Nutrients,2019,11(10):2496.
[14] 林霜,吴丹丹,陈书进,等.注意缺陷多动障碍儿童的体格生长和膳食特征:一项横断面研究[J].中国当代儿科杂志,2023,25(7):711-717.
Lin S,Wu DD,Chen SJ,et al.Physical growth and dietary characteristics of children with attention deficit hyperactivity disorder:A cross-sectional study[J].Chin J Contemporary Pediatrics,2023,25(7):711-717.(in Chinese)
[15] Garcia-Hermoso A,Ezzatvar Y,Izquierdo M,et al.Can an active lifestyle reduce the risk of obesity in adulthood among adolescents with attention-deficit/hyperactivity disorder symptoms? An ambispective cohort study[J].Psychiatry Res,2024,334:115770.
[16] Seymour KE,Reinblatt SP,Benson L,et al.Overlapping neurobehavioral circuits in ADHD,obesity,and binge eating:Evidence from neuroimaging research[J].CNS Spectr,2015,20(4):401-411.
[17] Barkley RA.Behavioral inhibition,sustained attention,and executive functions:Constructing a unifying theory of ADHD[J].Psychol Bull,1997,121(1):65-94.
[18] Graziano PA,Bagner DM,Waxmonsky JG,et al.Co-occurring weight problems among children with attention deficit/hyperactivity disorder:The role of executive functioning[J].Int J Obes (Lond),2012,36(4):567-572.
[19] Hayes JF,Eichen DM,Barch DM,et al.Executive function in childhood obesity:Promising intervention strategies to optimize treatment outcomes[J].Appetite,2018,124:10-23.
[20] Turan S,Tuncturk M,Ciray RO,et al.ADHD and risk of childhood adiposity:A review of recent research[J].Curr Nutr Rep,2021,10(1):30-46.
[21] Micai M,Fatta LM,Gila L,et al.Prevalence of co-occurring conditions in children and adults with autism spectrum disorder:A systematic review and meta-analysis[J].Neurosci Biobehav Rev,2023,155:105436.
[22] Sammels O,Karjalainen L,Dahlgren J,et al.Autism spectrum disorder and obesity in children:A systematic review and meta-analysis[J].Obes Facts,2022,15(3):305-320.
[23] Kahathuduwa CN,West BD,Blume J,et al.The risk of overweight and obesity in children with autism spectrum disorders:A systematic review and meta-analysis[J].Obes Rev,2019,20(12):1667-1679.
[24] Levy SE,Pinto-Martin JA,Bradley CB,et al.Relationship of weight outcomes,co-occurring conditions,and severity of autism spectrum disorder in the study to explore early development[J].J Pediatr,2019,205:202-209.
[25] Healy S,Aigner CJ,Haegele JA.Prevalence of overweight and obesity among US youth with autism spectrum disorder[J].Autism,2019,23(4):1046-1050.
[26] van der Lubbe A,Swaab H,Vermeiren R,et al.Novel insights into obesity in preschool children with autism spectrum disorder[J].Child Psychiatry Hum Dev,2024.doi:10.1007/s10578-024-01679-1.
[27] Ptomey LT,Walpitage DL,Mohseni M,et al.Weight status and associated comorbidities in children and adults with down syndrome,autism spectrum disorder and intellectual and developmental disabilities[J].J Intellect Disabil Res,2020,64(9):725-737.
[28] Dhaliwal KK,Orsso CE,Richard C,et al.Risk factors for unhealthy weight gain and obesity among children with autism spectrum disorder[J].Int J Mol Sci,2019,20(13):3285.
[29] Zheng Z,Zhang L,Li S,et al.Association among obesity,overweight and autism spectrum disorder:A systematic review and meta-analysis[J].Sci Rep,2017,7(1):11697.
[30] Kahathuduwa CN,West B,Mastergeorge A.Effects of overweight or obesity on brain resting state functional connectivity of children with autism spectrum disorder[J].J Autism Dev Disord,2019,49(12):4751-4760.
[31] Kupis L,Goodman ZT,Kircher L,et al.Altered patterns of brain dynamics linked with body mass index in youth with autism[J].Autism Res,2021,14(5):873-886.
[32] Kim T,Kwon EH.Investigating socioecological obesogenic factors in children with autism spectrum disorder[J].Fronti Public Health,2022,10:867456.
[33] Hendrix CG,Prins MR,Dekkers H.Developmental coordination disorder and overweight and obesity in children:A systematic review[J].Obes Rev,2014,15(5):408-423.
[34] Zhu YC,Wu SK,Cairney J.Obesity and motor coordination ability in Taiwanese children with and without developmental coordination disorder[J].Res Dev Disabil,2011,32(2):801-807.
[35] Barros WMA,da Silva KG,Silva RKP,et al.Effects of overweight/obesity on motor performance in children:A systematic review[J].Front Endocrinol (Lausanne),2021,12:759165.
[36] 刘明霞,花静,柯李,等.中国儿童发育性协调障碍现况分析[J].中华儿科杂志,2021,59(11):928-934.
Liu MX,Hua J,Ke L,et al.Analysis of developmental coordination disorder in Chinese children[J].Chin J Pediatr,2021,59(11):928-934.(in Chinese)
[37] Biino V,Pellegrini B,Zoppirolli C,et al.Gross motor coordination in relation to weight status:A longitudinal study in children and pre-adolescents[J].Front Public Health,2023,11:1242712.
[38] Fernandes AC,Viegas AA,Lacerda ACR,et al.Association between executive functions and gross motor skills in overweight/obese and eutrophic preschoolers:Cross-sectional study[J].BMC Pediatr,2022,22(1):498.
[39] Noordstar JJ,Volman MJM.Self-perceptions in children with probable developmental coordination disorder with and without overweight[J].Res Dev Disabil,2020,99:103601.
[40] Maiano C,Hue O,Morin AJ,et al.Prevalence of overweight and obesity among children and adolescents with intellectual disabilities:A systematic review and meta-analysis[J].Obes Rev,2016,17(7):599-611.
[41] Yuan YQ,Liu Y,Wang MJ,et al.Prevalence of overweight and obesity in children and adolescents with intellectual disabilities in China[J].J Intellect Disabil Res,2021,65(7):655-665.
[42] Emerson E,Robertson J,Baines S,et al.Obesity in British children with and without intellectual disability:Cohort study[J].BMC Public Health,2016,16:644.
[43] 马冰洁,卢少敏,邢艳菲,等.超重肥胖儿童智力水平及执行功能的表现特征[J].中国儿童保健杂志,2023,31(6):601-605.
Ma BJ,Lu SM,Xing YF,et al.Characteristics of intelligence and executive function in overweight and obese children[J].Chin J Child Health Care,2023,31(6):601-605.(in Chinese)
[44] Belsky DW,Caspi A,Goldman-Mellor S,et al.Is obesity associated with a decline in intelligence quotient during the first half of the life course?[J].Am J Epidemiol,2013,178(9):1461-1468.
[45] Norris T,Salzmann A,Henry A,et al.The relationship between adiposity and cognitive function:A bidirectional Mendelian randomization study in UK Biobank[J].Int J Epidemiol,2023,52(4):1074-1085.
[46] Wright L,Davies NM,Bann D.The association between cognitive ability and body mass index:A sibling-comparison analysis in four longitudinal studies[J].PLoS Med,2023,20(4):e1004207.
[47] Cadenas-Sanchez C,Migueles JH,Verdejo-Roman J,et al.Physical activity,sedentary time,and fitness in relation to brain shapes in children with overweight/obesity:Links to intelligence[J].Scand J Med Sci Sports,2023,33(3):319-330.
[48] Migueles JH,Cadenas-Sanchez C,Esteban-Cornejo I,et al.Associations of sleep with gray matter volume and their implications for academic achievement,executive function and intelligence in children with overweight/obesity[J].Pediatr Obes,2021,16(2):e12707.
[49] 刘洋,原雅青,刘飏.智力障碍儿童青少年超重肥胖状况及影响因素研究进展[J].中国学校卫生,2018,39(2):317-320.
Liu Y,Yuan YQ,Liu B.Progress in the study of overweight and obesity status and influencing factors in children and adolescents with intellectual disabilities[J].Chin J School Health,2018,39(2):317-320.(in Chinese)
[50] Carvalho LML,D′Angelo CS,Villela D,et al.Genetic investigation of syndromic forms of obesity[J].Int J Obes (Lond),2022,46(9):1582-1586.
[51] Zwack CC,McDonald R,Tursunalieva A,et al.Exploration of diet,physical activity,health knowledge and the cardiometabolic profile of young adults with intellectual disability[J].J Intellect Disabil Res,2022,66(6):517-532.
[52] Bodde AE,White DA,Forseth B,et al.Parent factors associated with BMI,diet,and physical activity of adolescents with intellectual and developmental disabilities[J].Disabil Health J,2023,16(4):101507.