Dose-response relationship between weight loss rate and changes in resting metabolic rate of obese adolescents

QIN Yuling; ZHU Lin; CHENG Guodong

doi:10.11852/zgetbjzz2024-0795

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (2) : 155-159. DOI: 10.11852/zgetbjzz2024-0795

Original Articles

Dose-response relationship between weight loss rate and changes in resting metabolic rate of obese adolescents

QIN Yuling¹, ZHU Lin², CHENG Guodong¹

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Abstract

Objective To investigate the dose-response relationship between weight loss rate and changes in resting metabolic rate(RMR) in adolescents with obesity, so as to provide scientific and accurate theoretical support for the prevention of weight rebound in adolescents with obesity. Methods From July to August 2023,sixty obese adolescents aged 10 - 17 were recruited and underwent a 4-week weight loss intervention.The weight loss rate was calculated as [(post-intervention weight after intervention －pre-intervention weight) ×(－1) /weight before intervention] ×100%. A gas metabolism analyzer was used to collect oxygen intake and carbon dioxide exhalation, which were then substituted into the Weir formula to determine RMR. The adjusted Δ relative resting metabolic rate(ΔRMR) per kilogram of body weight change was calculated as the difference between post-intervention and pre-intervention values. Paired-sample t-test was used to compare differences in weight and relative RMR before and after the weight loss intervention. Linear regression analysis was conducted to assess the dose-effect relationship between weight loss rate and ΔRMR, while restricted cubic spline(RCS) analysis was employed to examine threshold effects. Results Forty-nine obese adolescents were included in the statistical analysis,(including 26 males) with a mean age of(13.15±1.80) years and a mean body mass index(BMI) of(31.20±3.91) kg/m². Significant weight loss was observed after the 4-week intervention(t=20.486, P<0.05), while there was no significant change in relative RMR before and after the intervention(t=0.222, P>0.05). Linear regression analysis showed that for every 1% increase in weight loss rate, ΔRMR increased by 0.874kCal/(d·kg)(95%CI: 0.185 to 1.563, P<0.05). RCS results indicated a nonlinear dose-effect relationship between weight loss rate and ΔRMR among obese adolescents after adjusting for age, sex, and baseline weight(P-Nonlinear<0.05). Specifically, when the weight loss rate was ≤7.90%, each additional 1% of weight loss was associated with an increase in ΔRMR by 2.245kCal/(d·kg)(95%CI: 1.032 to 3.467, P<0.05). However, when the weight loss rate exceeded 7.90%, further increases in the weight loss rate did not significantly elevate ΔRMR(P>0.05). Conclusions There is a nonlinear dose-response relationship and threshold effect between 4-week weight loss and changes in RMR among obese adolescents. When the weight loss rate does not exceed 7.90%, there is a quantitative relationship with changes in RMR, such that increasing the weight loss rate gradually enhances changes in RMR. Once the weight loss rate exceeds 7.90%, the relationship between them is not significant.

Key words

weight loss rate / resting metabolic rate / dose-response relationship / obesity / adolescents

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QIN Yuling, ZHU Lin, CHENG Guodong. Dose-response relationship between weight loss rate and changes in resting metabolic rate of obese adolescents[J]. Chinese Journal of Child Health Care. 2025, 33(2): 155-159 https://doi.org/10.11852/zgetbjzz2024-0795

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