Abstract: Objective To investigate the nutritional status of vitamin D in children of 0~14 years old for providing reasonable scientific basis of vitamin D supplement for children in Guangzhou. Method ELISA was used to detect serum levels of 25-hydroxy vitamin D[25-(OH)D] in 1 000 children who received physical examination in child health care department of the hospital. Results A total of 634 children were found with deficiency and insufficiency of 25-(OH)D (63.4%), and 366 children were sufficiency of 25-(OH)D (36.6%).The 25-hydroxy vitamin D levels in aged 0~1 and 1~2 groups were much higher than that in the other groups, and the serum 25-(OH)D level decreased with age in children over 2-years old.Serum 25-(OH)D level had statistically significant difference between boys and girls aged 7~14, but no significant difference in aged 0~7.According to seasons, the order of the serum 25-(OH)D level was summer＞autumn＞spring＞winter.97 Children were deficiency or insufficiency of 25-(OH)D in winter (70.29%), which was much higher than that in other seasons(P＜0.05). Conclusion Vitamin D deficiency or insufficiency of children is common in Guangzhou, especially in winter and older children.

Key words: 25-hydroxy vitamin D, vitamin D, children

摘要： 目的 了解0~14岁儿童体内维生素D的营养状况, 为本地区儿童合理补充维生素D提供科学依据。方法 对广州中山大学附属第三医院儿童保健门诊进行常规体检的1 000例0~14岁的儿童采用酶联免疫法检测血清25-羟维生素D[25-hydroxy vitamin D, 25-(OH)D]水平。结果 25-(OH)D缺乏及不足者634例(63.4%);25-( OH) D水平充足者366例(36.6%)。0~1和1~2岁组儿童血清25-(OH)D水平最高, 2岁后儿童随着年龄增长逐渐下降(P＜0.01)。0~7岁男、女童血清 25-(OH)D水平差异无统计学意义(P＞0.05), 但在7~14岁组儿童男、女比较差异有统计学意义(P＜0.01)。血清25-(OH)D水平夏＞秋＞春＞冬, 冬季维生素D缺乏或不足的检出率为70.29%, 高于其他季节(P＜0.05)。结论 0~14岁儿童 25-(OH)D平均水平低下, 普遍存在维生素D缺乏或不足, 特别是在冬季和年长儿童。

关键词: 25-羟维生素D, 维生素D, 儿童