关键词: 窒息, 脑损伤, 新生儿, 危险因素

Abstract: Objective To explore the risk factors for perinatal hypoxic ischemic brain damage in asphyxiated newborn infants. Method A retrospective study was carried out in 102 asphyxiated newborn infants from Nov.2010 to the end of Jun.2011 in Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command of People's Liberation Army. Results In 102 asphyxiated newborn infants,46 new born infants were complicated with hypoxic ischemic brain damage(HIBD).The clinical data of the HIBD group (n=46) were compared with those of the HIBD negative group (n=56).The gestational age,umbilical cord abnormalities,placental abruption,meconium,abnormal fetal heart rate and hypertensive disorders in pregnancy were more common in the perinatal HIBD group (P<0.05).Logistic regression analysis showed gestational age,umbilical cord abnormalities,placental abruption,meconium and hypertensive disorders in pregnancy were the risk factors of HIBD in asphyxiated new born infants. Conclusion Asphyxiated newborn infants with the above mentioned risk factors should be given with appropriate intervention and resuscitation,thereby may prevent the perinatal asphyxia and minimize the occurrence of HIBD.

Key words: asphyxia, brain damage, neonate, risk factors