孟德尔随机化法探究新生儿高胆红素血症与抽动障碍的因果关联

doi:10.11852/zgetbjzz2023-1163

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (10): 1116-1121.DOI: 10.11852/zgetbjzz2023-1163

孟德尔随机化法探究新生儿高胆红素血症与抽动障碍的因果关联

崔鹏源¹, 李贵平²

1.西南医科大学中西医结合学院,四川泸州 646000;
2.西南医科大学附属中医医院新生儿科

收稿日期:2023-11-07 修回日期:2024-03-14 发布日期:2024-10-11 出版日期:2024-10-10
通讯作者: 李贵平,E-mail:15328343317@126.com
作者简介:崔鹏源(1999-),女,硕士研究生在读,主要研究方向为中西医结合治疗儿科神经精神类疾病。
基金资助:
四川省中医药管理局中医药科研专项面上项目(2021MS162)

Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization

CUI Pengyuan¹, LI Guiping²

1. School of Integrated Traditional Chinese and Western Medicine,Southwest Medical University,Luzhou,Sichuan 646000, China;
2. Department of Neonatology,Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University

Received:2023-11-07 Revised:2024-03-14 Online:2024-10-10 Published:2024-10-11
Contact: LI Guiping,E-mail:15328343317@126.com

摘要/Abstract

摘要： 目的采用两样本孟德尔随机化(TSMR)分析法,探讨新生儿高胆红素血症与抽动障碍(TD)的因果关联,以期为TD的机制研究提供线索。方法利用全基因组关联研究(GWAS)的数据,暴露因素为新生儿高胆红素血症,结局变量分别为TD、短暂性TD和发声性TD,通过MR分析,将逆方差加权(IVW)作为主要分析方法,MR-Egger回归和加权中位数(WM)补充方法分析二者之间的潜在关系,利用Cochran Q检验、MR-Egger回归截距进行敏感性分析。结果逆方差加权法分析显示,新生儿高胆红素血症与TD发病风险之间存在潜在因果关系(OR=1.053,95%CI:1.006~1.102,P=0.024),但与其他类型抽动无潜在因果关联。敏感性分析显示不存在多效性和异质性(P>0.05),结果可靠。结论新生儿高胆红素血症与TD之间存在潜在因果关系,但二者关联需要更大样本量进一步验证。

关键词: 新生儿高胆红素血症, 抽动障碍, 孟德尔随机化

Abstract: Objective To explore the causal relationship between neonatal hyperbilirubinemia and tic disorder (TD) by two-sample Mendelian randomized analysis (TSMR),in order to provide insights for the mechanism research of TD. Methods Data of genome-wide association study (GWAS) was used in this study.The exposure factor was neonatal hyperbilirubinemia,and the outcome variables were TD,multiple TD and vocal TD,respectively.Through MR analysis,inverse variance weighted (inverse-variance weighted,IVW) was used as the main analysis method, MR-Egger regression and weighted median (weighted median,WM) supplementary Methods were used to analyze the potential relationship between them.Cochran Q test and MR-Egger regression intercept were used to analyze the sensitivity. Results The inverse variance weighting method,showed that there was a potential causal relationship between neonatal hyperbilirubinemia and the risk of TD(OR=1.053,95%CI:1.006 - 1.102,P=0.024),but there was no potential causal correlation with other types of TD.Sensitivity analysis showed that there was no pleiotropy and heterogeneity(P>0.05),and the result was reliable. Conclusions There is a potential causal relationship between neonatal hyperbilirubinemia and TD,but the relationship needs to be further verified by a larger sample size.

Key words: neonatal hyperbilirubinemia, tic disorder, Mendelian randomization

中图分类号:

R722.1

崔鹏源, 李贵平. 孟德尔随机化法探究新生儿高胆红素血症与抽动障碍的因果关联[J]. 中国儿童保健杂志, 2024, 32(10): 1116-1121.

CUI Pengyuan, LI Guiping. Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization[J]. Chinese Journal of Child Health Care, 2024, 32(10): 1116-1121.

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孟德尔随机化法探究新生儿高胆红素血症与抽动障碍的因果关联

Causal relationship between neonatalhy perbilirubinemia and tic disorder by Mendelian randomization

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