目的 采用两样本孟德尔随机化(TSMR)分析法,探讨新生儿高胆红素血症与抽动障碍(TD)的因果关联,以期为TD的机制研究提供线索。方法 利用全基因组关联研究(GWAS)的数据,暴露因素为新生儿高胆红素血症,结局变量分别为TD、短暂性TD和发声性TD,通过MR分析,将逆方差加权(IVW)作为主要分析方法,MR-Egger回归和加权中位数(WM)补充方法分析二者之间的潜在关系,利用Cochran Q检验、MR-Egger回归截距进行敏感性分析。 结果 逆方差加权法分析显示,新生儿高胆红素血症与TD发病风险之间存在潜在因果关系(OR=1.053,95%CI:1.006~1.102,P=0.024),但与其他类型抽动无潜在因果关联。敏感性分析显示不存在多效性和异质性(P>0.05),结果可靠。 结论 新生儿高胆红素血症与TD之间存在潜在因果关系,但二者关联需要更大样本量进一步验证。
Abstract
Objective To explore the causal relationship between neonatal hyperbilirubinemia and tic disorder (TD) by two-sample Mendelian randomized analysis (TSMR),in order to provide insights for the mechanism research of TD. Methods Data of genome-wide association study (GWAS) was used in this study.The exposure factor was neonatal hyperbilirubinemia,and the outcome variables were TD,multiple TD and vocal TD,respectively.Through MR analysis,inverse variance weighted (inverse-variance weighted,IVW) was used as the main analysis method, MR-Egger regression and weighted median (weighted median,WM) supplementary Methods were used to analyze the potential relationship between them.Cochran Q test and MR-Egger regression intercept were used to analyze the sensitivity. Results The inverse variance weighting method,showed that there was a potential causal relationship between neonatal hyperbilirubinemia and the risk of TD(OR=1.053,95%CI:1.006 - 1.102,P=0.024),but there was no potential causal correlation with other types of TD.Sensitivity analysis showed that there was no pleiotropy and heterogeneity(P>0.05),and the result was reliable. Conclusions There is a potential causal relationship between neonatal hyperbilirubinemia and TD,but the relationship needs to be further verified by a larger sample size.
关键词
新生儿高胆红素血症 /
抽动障碍 /
孟德尔随机化
Key words
neonatal hyperbilirubinemia /
tic disorder /
Mendelian randomization
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基金
四川省中医药管理局中医药科研专项面上项目(2021MS162)
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