脐膨出畸形胎儿的妊娠结局及发育随访

doi:10.11852/zgetbjzz2023-1323

中国儿童保健杂志 ›› 2024, Vol. 32 ›› Issue (10): 1145-1148.DOI: 10.11852/zgetbjzz2023-1323

脐膨出畸形胎儿的妊娠结局及发育随访

滕云飞¹, 段钊¹, 张婷婷¹, 王惠萍², 乞艳华³, 郭琳琼⁴, 李小鹏¹

1.西安交通大学第二附属医院妇产科,陕西西安 710004;
2.西安交通大学第二附属医院新生儿科;
3.西安交通大学第二附属医院超声研究室;
4.西北妇女儿童医院妇产科

收稿日期:2023-12-20 修回日期:2024-03-01 发布日期:2024-10-11 出版日期:2024-10-10
通讯作者: 段钊,E-mail:duanzhao8@163.com;李小鹏,E-mail:xiaopengli8@126.com
作者简介:滕云飞(1989-),男,硕士研究生,主要研究方向为围产医学。
基金资助:
陕西省重点研发计划项目(2021SF-134);腾讯生机计划2023健康创新公益挑战项目(202407090006)

Pregnancy outcome of the fetus with omphalocele deformity

TENG Yunfei¹, DUAN Zhao¹, ZHANG Tingting¹, WANG Huiping², QI Yanhua³, GUO Linqiong⁴, LI Xiaopeng¹

1. Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi′an Jiaotong University, Xi′an, Shaanxi 710004, China;
2. Department of Neonatology, The Second Affiliated Hospital of Xi′an Jiaotong University;
3. Department of Ultrasonography, The Second Affiliated Hospital of Xi′an Jiaotong University;
4. Department of Obstetrics and Gynecology, Northwest Women′s and Children′s Hospital

Received:2023-12-20 Revised:2024-03-01 Online:2024-10-10 Published:2024-10-11
Contact: DUAN Zhao, E-mail: duanzhao8@126.com;LI Xiaopeng,E-mail:xiaopengli8@126.com

摘要/Abstract

摘要： 目的分析脐膨出畸形胎儿的妊娠结局及发育随访,为该病的临床诊治和预后提供参考。方法回顾性分析西安两家大型三甲医院产前诊断的44例胎儿脐膨出资料,按照出生时胎儿脐膨出大小分为两组,脐膨出≤5cm 组21例,脐膨出>5cm组(50%~75%肝脏位于囊内)23例。收集孕妇年龄、产次、分娩方式、是否合并其他畸形、分娩时妊娠周数、新生儿出生时体重、新生儿不良结局、新生儿性别、新生儿住院时间、新生儿禁食时间、母体孕期是否有妊娠合并症、新生儿远期发育随访资料,分析两组之间的妊娠结局。结果两组孕母年龄、孕周、产次、分娩方式、孕期是否有合并症,以及新生儿是否合并其他畸形、出生时体重、新生儿性别比较,差异无统计学意义(P>0.05)。与脐膨出≤5cm 组新生儿相比,脐膨出>5cm组新生儿住院时间、禁食时间较长,不良结局发生率较高,差异有统计学意义(t=3.054、0.918,χ²=5.750,P<0.05)。远期随访中,两组新生儿的术后喂养困难、运动功能、认知、体重发育、身高发育、行为、二次手术率比较,差异均无统计学意义(P>0.05)。结论大部分新生儿脐膨出≤5cm预后良好。应重视胎儿健康检查,孕期应定期行超声观察胎儿脐带发育情况,对于确诊脐膨出的畸形做好有效防控措施。

关键词: 胎儿脐膨出, 妊娠结局, 新生儿手术所需住院时间, 新生儿禁食时间, 远期发育随访

Abstract: Objective To analyze the pregnancy outcome of the fetus with omphalocele, so as to provide reference for clinical diagnosis, treatment and prognosis of the disease. Methods The data of 44 cases of fetal omphalocele diagnosed prenatal in two large Grade A hospitals in Xi′an were retrospectively analyzed. According to the size of the fetal omphalocele at birth, children were divided into two groups: omphalocele ≤5cm group (n=21) and omphalocele >5cm group(n=23) (50% - 75% of the liver was in the capsule). Data on pregnant women′s age, time of delivery, mode of delivery, whether there were other malformations, gestational weeks at delivery, birth weight of newborns, adverse neonatal outcomes, neonatal sex, neonatal hospitalization time, neonatal fasting time, whether there were pregnancy complications during pregnancy, and long-term follow-up of neonatal development were collected and analyzed. Results There was no significant difference between the two groups in age, gestational age, time of delivery, mode of delivery, complications during pregnancy, birth weight and newborn sex (P>0.05). Compared with the omphalocele ≤5cm group, the hospital stay and fasting time of neonates in the omphalocele >5cm group were longer, and the incidence of adverse outcomes was higher, with statistical significance (t=3.054,0.918,χ²=5.750,P<0.05). In the long-term follow-up, there were no significant differences in postoperative feeding difficulties, motor function, cognition, weight development, height development, behavior and the rate of second operation between the two groups (P>0.05). Conclusions Most newborns with omphalocele ≤5cm have a good prognosis. Attention should be paid to fetal health examination, and regular ultrasound should be performed during pregnancy to observe the development of fetal umbilical cord, and effective prevention and control measures should be taken to diagnose the malformation of omphalocele.

Key words: fetal omphalocele, pregnancy outcome, length of hospital stay required for neonatal operation, fasting time of newborn, long-term development follow-up

中图分类号:

R714.5

滕云飞, 段钊, 张婷婷, 王惠萍, 乞艳华, 郭琳琼, 李小鹏. 脐膨出畸形胎儿的妊娠结局及发育随访[J]. 中国儿童保健杂志, 2024, 32(10): 1145-1148.

TENG Yunfei, DUAN Zhao, ZHANG Tingting, WANG Huiping, QI Yanhua, GUO Linqiong, LI Xiaopeng. Pregnancy outcome of the fetus with omphalocele deformity[J]. Chinese Journal of Child Health Care, 2024, 32(10): 1145-1148.

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脐膨出畸形胎儿的妊娠结局及发育随访

Pregnancy outcome of the fetus with omphalocele deformity

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