miRNA与脂肪细胞分化、肥胖

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (5): 419-423.

miRNA与脂肪细胞分化、肥胖

季晨博^1,2 综述, 郭锡熔^1,2 审校

1 南京医科大学附属南京妇幼保健院儿童保健科,江苏南京 210004;
2 南京医科大学儿科研究所,江苏南京 210029

收稿日期:2012-03-29 发布日期:2012-05-06 出版日期:2012-05-06
通讯作者: 郭锡熔,E-mail:xrguo@njmu.edu.cn
作者简介:季晨博(1983-),男,住院医师,博士学位,主要研究方向为儿童肥胖
基金资助:
江苏省医学创新团队项目(LJ201108);江苏省自然科学基金(BK2011107);南京市科技发展计划(201104013)

Received:2012-03-29 Online:2012-05-06 Published:2012-05-06

摘要/Abstract

摘要： 肥胖已经成为全球面临的一个严重公共健康问题。肥胖是机体能量失衡导致脂肪过度积聚为重要特征的一种代谢异常,主要表现为脂肪细胞数量异常增加和体积异常增大,因此深入理解脂肪细胞分化机制对肥胖防治具有重要意义。microRNA(miRNA)是近年来在真核生物体内发现的、一类长度约22nt的内源性非编码单链小RNA,通过与靶标mRNA不完全互补配对,发挥降解靶mRNA或抑制靶mRNA翻译的作用。miRNA几乎参与所有生命活动的调节和大多数疾病的发病过程,包括脂肪细胞分化、肥胖发生发展。本文主要综述miRNA在脂肪细胞分化、肥胖研究领域取得的成果,并分析该领域的现状、不足及前景。

关键词: miRNA, 脂肪细胞, 分化, 肥胖

中图分类号:

R725

季晨博综述, 郭锡熔审校. miRNA与脂肪细胞分化、肥胖[J]. 中国儿童保健杂志, 2012, 20(5): 419-423.

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