孕期摄入维生素D对婴幼儿哮喘发生率影响的系统回顾和荟萃分析

doi:10.11852/zgetbjzz2018-26-03-16

中国儿童保健杂志 ›› 2018, Vol. 26 ›› Issue (3): 286-289.DOI: 10.11852/zgetbjzz2018-26-03-16

孕期摄入维生素D对婴幼儿哮喘发生率影响的系统回顾和荟萃分析

陈慧, 林晓霞, 陈燕惠

福建医科大学附属协和医院儿科,福建福州 350001

收稿日期:2017-07-10 发布日期:2018-03-10 出版日期:2018-03-10
通讯作者: 陈燕惠,E-mail:yanhui_0655@126.com
作者简介:陈慧(1984-),女,福建人,主治医师,硕士学位,主要研究方向儿内科呼吸系统疾病、心血管系统疾病。
基金资助:
福建省临床重点专科建设项目(2015-593)

Meta-analysis on association of vitamin D intake in pregnancy with infants asthma

CHEN Hui, LIN Xiao-xia, CHEN Yan-hui

Department of Pediatrics,Fujian Medical University Union Hospital,Fuzhou,Fujian 350001,China

Received:2017-07-10 Online:2018-03-10 Published:2018-03-10
Contact: CHEN Yan-hui,E-mail:yanhui_0655@ 126.com

摘要/Abstract

摘要： 目的进行孕期摄入维生素D对婴幼儿哮喘发生率影响的系统分析。方法检索中国知网、万方数据库、维普科技期刊数据库、PubMed数据库、OVID数据库,收集国内外关于孕期摄入维生素D对婴幼儿哮喘发生率影响的研究进行Meta分析。结果 5篇前瞻性队列研究文献和4篇RCT文献纳入研究。1)对5项前瞻性队列研究进行描述性分析显示,孕期饮食维生素D摄入量高的孕妇比摄入量低的孕妇其后代发生哮喘及喘息的几率较小,差异均具有统计学意义。2)对4项RCT中的2项进行Meta分析,共1 355组孕妇-婴幼儿纳入研究,其中补充维生素D组683例,安慰剂对照组672组,结果显示补充维生素D组的孕妇比安慰剂组的孕妇后代发生婴幼儿哮喘的风险较小(OR=0.71,95%CI:0.54～0.92,P=0.01)。结论孕期摄入较大剂量的维生素D有助于减少婴幼儿哮喘的发生率。

关键词: 维生素D, 孕期, 婴幼儿哮喘, Meta分析

Abstract: Objective To evaluate the association of vitamin D intake in pregnancy with infants asthma. Method VIP,Wanfang,CNKI,PubMed,and OVID databases were searched,in order to collect studies regarding association of vitamin D intake in pregnancy with infants asthma to conduct Meta-analysis. Results Totally 5 prospective cohort studies and 4 RCTs were included in this study.1)All 5 articles had reported that higher maternal intake of vitamin D during pregnancy may significantly decrease the risk of asthma or wheeze in early childhood.2)Two of the fore RCTs were conducted Meta-analysis finally.A total of 1 355 mother-children pairs were enrolled,including 683 pairs in group with vitamin D supplementation and 672 pairs in group with placebo.The Results showed that prenatal vitamin D supplementation was reduced the risk of infants asthma compared to the placebo (OR=0.71;95%CI:0.54～0.92;P=0.01). Conclusion Higher prenatal intake of vitamin D may decrease the risk of infants asthma.

Key words: vitamin D, pregnancy, infants asthma, Meta-analysis

中图分类号:

R179

陈慧, 林晓霞, 陈燕惠. 孕期摄入维生素D对婴幼儿哮喘发生率影响的系统回顾和荟萃分析[J]. 中国儿童保健杂志, 2018, 26(3): 286-289.

CHEN Hui, LIN Xiao-xia, CHEN Yan-hui. Meta-analysis on association of vitamin D intake in pregnancy with infants asthma[J]. journal1, 2018, 26(3): 286-289.

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孕期摄入维生素D对婴幼儿哮喘发生率影响的系统回顾和荟萃分析

Meta-analysis on association of vitamin D intake in pregnancy with infants asthma

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