Effects of sleep fragmentation on cognitive function in children

doi:10.11852/zgetbjzz2024-0362

Abstract

Abstract: Sleep fragmentation refers to the state of several brief awakenings during night sleep, which is an intermittent sleep pattern, and its symptoms are manifested as difficulty in falling asleep again after waking up, daytime sleepiness, and lack of attention. Cognitive function includes executive function, attention deficit, learning and memory function, etc. This paper comprehensively analyzes the possible mechanism of the influence of sleep fragmentation on cognitive function, and expounds its clinical significance, so as to provide insights for further clinical research and treatment.

Key words: sleep fragmentation, cognitive function, executive function, attention deficit, memory function

摘要： 睡眠碎片化是指夜间睡眠中有多次简短的唤醒状态,是一种断断续续的睡眠模式,其症状表现为夜间醒来再次入睡困难,白天困倦,注意力不集中等。认知功能包括执行功能、注意缺陷、学习及记忆功能等,本文综合分析了睡眠碎片化对认知功能影响的可能机制,并阐述其临床意义,为进一步的临床研究和治疗提供思路。

关键词: 睡眠碎片化, 认知功能, 执行功能, 注意缺陷, 记忆功能

CLC Number:

R740

WANG Leilei, ZHAO Pengjun. Effects of sleep fragmentation on cognitive function in children[J]. Chinese Journal of Child Health Care, 2024, 32(11): 1241-1245.

王蕾蕾, 赵鹏军. 睡眠碎片化对儿童认知功能影响的研究进展[J]. 中国儿童保健杂志, 2024, 32(11): 1241-1245.

References

[1] Milena C, Serena S, Maurizio G, et al. EEG patterns prior to motor activations of parasomnias: A systematic review[J]. Nat Sci Sleep, 2021,13(1):713-728.
[2] Steffey MA, Scharf VF, Risselada M, et al. A narrative review of the pathophysiology and impacts of insufficient and disrupted sleep[J]. Can Vet J, 2023,64(6):579-587.
[3] Paruthi S, Brooks LJ, D'Ambrosio C, et al. Recommended amount of sleep for pediatric populations: A consensus statement of the american academy of sleep medicine[J]. JCSM, 2016,12(6):785-786.
[4] Girardeau G, Lopes-dos-Santos V. Brain neural patterns and the memory function of sleep[J]. Science, 2021,374(6567):560-564.
[5] Lewis LD. The interconnected causes and consequences of sleep in the brain[J]. Science, 2021,374(6567):564-568.
[6] Newbury CR, Crowley R, Rastle K, et al. Sleep deprivation and memory: Meta-analytic reviews of studies on sleep deprivation before and after learning[J]. Psychol Bull, 2021,147(11):1215-1240.
[7] Beattie L, Kyle SD, Espie CA, et al. Social interactions, emotion and sleep: A systematic review and research agenda[J]. Sleep Med, 2015,24(6):83-100.
[8] Santos IM, Silva A, Bem-Haja P, et al. The impact of sleep on face recognition memory: A scoping review[J]. Brain Sci, 2022,12(10):1385-1411.
[9] Perez E, Dzierzewski JM, Aiken-Morgan AT, et al. Anxiety and executive functions in mid-to-late life: The moderating role of sleep[J]. Aging Ment Health, 2019,24(9):1459-1465.
[10] Dzierzewski JM, Dautovich N, Ravyts S. Sleep and cognition in older adults[J]. Sleep Med Clin, 2018,13(1):93-106.
[11] Tai XY, Chen C, Manohar S, et al. Impact of sleep duration on executive function and brain structure[J]. Commun Biol, 2022,5(1):201-210.
[12] Alber J, Alladi S, Bae HJ, et al. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities[J]. Alzh Dement-Trci, 2019,5(1):107-117.
[13] Sexton CE, Storvsve AB, Walhovd KB, et al. Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults[J]. AAN, 2014,83(11):967-973.
[14] Walhovd KB, Zsoldos E, Westerhausen R, et al. Self-reported sleep relates to hippocampal atrophy across the adult lifespan: Results from the lifebrain consortium[J]. Sleep, 2020,43(5):1-15.
[15] Cheng W, Rolls E, Gong W, et al. Sleep duration, brain structure, and psychiatric and cognitive problems in children[J]. Mol Psychiatry, 2020,26(8):3992-4003.
[16] Brevik EJ, Lundervold AJ, Halmøy A, et al. Prevalence and clinical correlates of insomnia in adults with attention-deficit hyperactivity disorder[J]. Acta Psychiatr Scand 2017,136(2):220-227.
[17] Wynchank D, Have M, Bijlenga D, et al. The association between insomnia and sleep duration in adults with attention-deficit hyperactivity disorder: Results from a general population study[J]. JCSM, 2018,14(03):349-357.
[18] Gregory AM, Agnew-Blais JC, Matthews T, et al. ADHD and sleep quality: Longitudinal analyses from childhood to early adulthood in a twin cohort[J]. J Clin Child Adolesc Psychol,2016,46(2):284-294.
[19] Wiggs L, Montgomery P, Stores G. Actigraphic and parent reports of sleep patterns and sleep disorders in children with subtypes of attention-deficit hyperactivity disorder[J]. Sleep, 2005,28(11):1437-1445.
[20] Hvolby A. Associations of sleep disturbance with adhd: Implications for treatment[J]. Atten Def Hyp Disord, 2014,7(1):1-18.
[21] Petti T, Gupta M, Fradkin Y, et al. Management of sleep disorders in autism spectrum disorder with co-occurring attention-deficit hyperactivity disorder: Update for clinicians[J]. BJ Psych Open, 2023,10(1):1-13.
[22] O'Brien LM, Holbrook CR, Mervis CB, et al. Sleep and neurobehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder[J]. Pediatrics, 2003,111(3):554-563.
[23] Friedman NP, Corley RP, Hewitt JK, et al. Individual differences in childhood sleep problems predict later cognitive executive control[J]. Sleep, 2009,32(3):323-333.
[24] Miano S, Donfrancesco R, Bruni O, et al. NREM sleep instability is reduced in children with attention-deficit/hyperactivity disorder[J]. Sleep, 2006,29(6):797-803.
[25] Ringli M, Souissi S, Kurth S, et al. Topography of sleep slow wave activity in children with attention-deficit/hyperactivity disorder[J]. Cortex, 2013,49(1):340-347.
[26] Scarpelli S, Gorgoni M, D'Atri A, et al. Advances in understanding the relationship between sleep and attention deficit-hyperactivity disorder (ADHD)[J]. J Clin Med Res, 2019,8(10):1737-1756.
[27] Zhang DW, Li H, Wu ZL, et al. Electroencephalogram Theta/Beta ratio and spectral power correlates of executive functions in children and adolescents with AD/HD[J]. J Atten Disord, 2017,23(7):721-732.
[28] Cremone A, Lugo-Candelas CI, Harvey EA, et al. REM Theta activity enhances inhibitory control in typically developing children but not children with ADHD symptoms[J]. Exp Brain Res, 2017,235(5):1491-1500.
[29] Zamore Z, Veasey S. Neural consequences of chronic sleep disruption[J]. Trends Neurosci, 2022,45(9):678-691.
[30] Chidambaram AG, Jhawar S, McDonald CM, et al. Sleep disordered breathing in children with neuromuscular disease[J]. Children, 2023,10(10):1-11.
[31] Hoedlmoser K,Peigneux P, Rauchs G. Recent advances in memory consolidation and information processing during sleep[J]. J Sleep Res, 2022,31(4):1-36.
[32] Astill RG, Van der Heijden KB, Van Ijzendoorn MH, et al. Sleep, cognition, and behavioral problems in school-age children: A century of research meta-analyzed[J]. Psychological Bulletin, 2012,138(6):1109-1138.
[33] Dahat P, Toriola S, Satnarine T, et al. Correlation of various sleep patterns on different types of memory retention: A systematic review[J]. Cureus, 2023,15(7):1-14.
[34] Memon AA, Coleman JJ, Amara AW. Effects of exercise on sleep in neurodegenerative disease[J]. Neurobiol Dis, 2020,140(7):1-21.
[35] Borbély A. The two-process model of sleep regulation: Beginnings and outlook[J]. J Sleep Res, 2022,31(4):1-8.
[36] Tononi G, Cirelli C. Sleep and the price of plasticity: From synaptic and cellular homeostasis to memory consolidation and integration[J]. Neuron, 2014,81(1):12-34.
[37] Zeller CJ, Züst MA, Wunderlin M, et al. The promise of portable remote auditory stimulation tools to enhance slow-wave sleep and prevent cognitive decline[J]. J Sleep Res, 2023,32(4):13818-13827.
[38] Zhang YJ, Gruber R. Can slow-wave sleep enhancement improve memory? A review of current approaches and cognitive outcomes[J]. Yale J Biol Med, 2019,92(1):63-80.
[39] Abel T, Havekes R, Saletin Jared M, et al. Sleep, plasticity and memory from molecules to whole-brain networks[J]. Curr Biol, 2013,23(17):774-788.
[40] Vecsey CG, Peixoto L, Choi JHK, et al. Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus[J]. Physiol Genomics, 2012,44(20):981-991.
[41] Mackiewicz M, Shockley KR, Romer MA, et al. Macromolecule biosynthesis: A key function of sleep[J]. Physiological Genomics, 2007,31(3):441-457.
[42] Xia ZG, Storm DR. Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory[J]. Learn Mem, 2012,19(9):369-374.
[43] Havekes R, Park AJ, Tolentino RE, et al. Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory[J]. J Neurosci, 2016,36(34):8936-8946.
[44] Zhu B, Dong YL, Xu ZP, et al. Sleep disturbance induces neuroinflammation and impairment of learning and memory[J]. Neurobiol Dis, 2012,48(3):348-355.
[45] Hudetz JA, Gandhi SD, Iqbal Z, et al. Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery[J]. J Anesth, 2010,25(1):1-9.
[46] Chauvette S, Seigneur J, Timofeev I. Sleep oscillations in the thalamocortical system induce long-term neuronal plasticity[J]. Neuron, 2012,75(6):1105-1113.
[47] Grosmark AD, Mizuseki K, Pastalkova E, et al. REM sleep reorganizes hippocampal excitability[J]. Neuron, 2012,75(6):1001-1007.
[48] Dash MB, Douglas CL, Vyazovskiy VV, et al. Long-term homeostasis of extracellular glutamate in the rat cerebral cortex across sleep and waking states[J]. J Neurosci, 2009,29(3):620-629.
[49] Ulrich D. Sleep spindles as facilitators of memory formation and learning[J]. Neural Plast, 2016,2016(2016):1-7.
[50] Mednick SC, McDevitt EA, Walsh JK, et al. The critical role of sleep spindles in hippocampal-dependent memory: A pharmacology study[J]. J Neurosci, 2013,33(10):4494-4504.