Research advance in the role of gut microbiota in attention deficit hyperactivity disorder

doi:10.11852/zgetbjzz2022-1269

Abstract

Abstract: The microbial-gut-brain axis (MGB), which is composed of gut microbiota and its metabolites together with the central nervous system, neuroendocrine system, neuroimmune system and autonomic nervous system, is considered to be a bridge between environmental risk factors and pathological mechanisms of ADHD. Monoamine neurotransmitter levels and hypothalamic-pituitary-adrenal (HPA) axis disturbances, which have received much attention in ADHD research, are closely related to MGB imbalance. Given that the differences in geographical environment and dietary habits may cause regional differences in the intestinal microbial composition, exploring the influence of living habits on the specific characteristics and metabolites of intestinal microbes in different regions and their role in the pathological process of ADHD is helpful to understand the mechanism of MGB involving in ADHD and to provide a basis for accurate ADHD prevention and treatment strategies as well as life guidance.

Key words: attention deficit hyperactivity disorder, microbiota-gut-brain axis, pathogenesis, environmental factors, biomarkers

摘要： 肠道微生物群及其代谢产物与中枢神经系统、神经内分泌系统、神经免疫系统、自主神经系统等共同构成的微生物-肠-脑轴(MGB)被认为是环境危险因素参与注意缺陷多动障碍(ADHD)病理机制的桥梁,在ADHD研究中深受关注的单胺类神经递质水平及下丘脑-垂体-肾上腺轴(HPA轴)紊乱与MGB失衡密切相关。肠道微生物组成存在地域差异,探究生活习惯对不同地区患者肠道微生物种属特点和代谢产物的影响及其在病理过程中的作用,有助于理解MGB参与ADHD发病的机制,为制定精确的ADHD防治策略及生活指导提供依据。

关键词: 注意缺陷多动障碍, 微生物-肠-脑轴, 发病机制, 环境因素, 生物标志物

CLC Number:

R749.94

ZHENG Jie, CHEN Yanhui. Research advance in the role of gut microbiota in attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care, 2023, 31(9): 986-989.

郑杰, 陈燕惠. 注意缺陷多动障碍与肠道微生物群的研究进展[J]. 中国儿童保健杂志, 2023, 31(9): 986-989.

References

[1] Liu Y, Grimm M, Dai WT, et al. CB-Dock: A web server for cavity detection-guided protein-ligand blind docking[J]. Acta Pharmacol Sin,2020,41(1):138-144.
[2] Thapar A, Cooper M, Eyre O, et al. What have we learnt about the causes of ADHD?[J]. J Child Psychol Psychiatry,2013,54(1):3-16.
[3] Wolraich ML, Chan E, Froehlich T, et al. ADHD diagnosis and treatment guidelines: A historical perspective[J]. Pediatrics,2019,144(4).
[4] Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, et al. A comprehensive review on the role of the gut microbiome in human neurological disorders[J]. Clin Microbiol Rev,2022,35(1):e33820.
[5] Chen Y, Zheng X, Xie L, et al. Glucocorticoids/glucocorticoid receptors effect on dopaminergic neurotransmitters in ADHD rats[J]. Brain Res Bull,2017,131:214-220.
[6] Vanicek T, Kutzelnigg A, Philippe C, et al. Altered interregional molecular associations of the serotonin transporter in attention deficit/hyperactivity disorder assessed with PET[J]. Hum Brain Mapp,2017,38(2):792-802.
[7] Buitelaar J, Bolte S, Brandeis D, et al. Toward precision medicine in ADHD[J]. Front Behav Neurosci,2022,16:900981.
[8] Bath KG, Manzano-Nieves G, Goodwill H. Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice[J]. Horm Behav,2016,82:64-71.
[9] Agha SS, Zammit S, Thapar A, et al. Maternal psychopathology and offspring clinical outcome:A four-year follow-up of boys with ADHD[J]. Eur Child Adolesc Psychiatry,2017,26(2):253-262.
[10] Dang LC, Samanez-Larkin GR, Young JS, et al. Caudate asymmetry is related to attentional impulsivity and an objective measure of ADHD-like attentional problems in healthy adults[J]. Brain Struct Funct,2016,221(1):277-286.
[11] Ma I, van Holstein M, Mies GW, et al. Ventral striatal hyperconnectivity during rewarded interference control in adolescents with ADHD[J]. Cortex,2016,82:225-236.
[12] Ma L, Chen YH, Chen H, et al. The function of hypothalamus-pituitary-adrenal axis in children with ADHD[J]. Brain Res,2011,1368:159-162.
[13] 陈燕惠,卢龙杰,林晓霞,等. 血清皮质醇作为生物标志物在注意缺陷多动障碍诊断中的价值[J]. 中华实用儿科临床杂志,2021,36(9):669-673.
Chen YH, Lu LJ, Lin XX, et al. Clinical value of serum cortisol as a biomarker in the diagnosis of attention deficit hyperactivity disorder[J]. Chin J Appl Clin Pediatr, 2021,36(9):669-673.(in Chinese)
[14] Chen YH, Zheng X, Xie L, et al. Glucocorticoids/glucocorticoid receptors effect on dopaminergic neurotransmitters in ADHD rats[J]. Brain Res Bull,2017,131:214-220.
[15] 陈燕惠,卢洪珠,郑杰,等. 糖皮质激素受体功能对大鼠前额叶单胺氧化酶A的影响及其交互作用[J]. 解剖学杂志,2021,44(4):295-299.
Chen YH, Lu HZ,Zheng J, et al. Effect of glucocorticoid receptor on monoamine oxidase Aand its interaction in rat prefrontal cortex[J]. Chinese Journal of Anatomy, 2021,44(4): 295-299. (in Chinese)
[16] Ma SR, Yu JB, Fu J, et al. Determination and application of nineteen monoamines in the gut microbiota targeting phenylalanine, tryptophan, and glutamic acid metabolic pathways[J]. Molecules,2021,26(5):1377.
[17] Michels N, Clarke G, Olavarria-Ramirez L, et al. Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts[J]. Psychoneuroendocrinology,2018,94:104-111.
[18] Barrett E, Ross RP, O'Toole PW, et al. gamma-Aminobutyric acid production by culturable bacteria from the human intestine[J]. J Appl Microbiol,2012,113(2):411-417.
[19] Chen H, Nwe PK, Yang Y, et al. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology[J]. Cell,2019,177(5):1217-1231.
[20] Vagnerova K, Vodicka M, Hermanova P, et al. Interactions between gut microbiota and acute restraint stress in peripheral structures of the hypothalamic-pituitary-adrenal axis and the intestine of male mice[J]. Front Immunol,2019,10:2655.
[21] Li C, Cai YY, Yan ZX. Brain-derived neurotrophic factor preserves intestinal mucosal barrier function and alters gut microbiota in mice[J]. Kaohsiung J Med Sci,2018,34(3):134-141.
[22] Derrien M, Alvarez AS, de Vos WM. The gut microbiota in the first decade of life[J]. Trends Microbiol,2019,27(12):997-1010.
[23] Cenit MC, Nuevo IC, Codoner-Franch P, et al. Gut microbiota and attention deficit hyperactivity disorder: New perspectives for a challenging condition[J]. Eur Child Adolesc Psychiatry, 2017, 26(9):1081-1092.
[24] Hsiao EY, Mcbride SW, Hsien S, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders[J]. Cell, 2013,155(7):1451-1463.
[25] Kumperscak HG, Gricar A, Ulen I, et al. A pilot randomized control trial with the probiotic strain lactobacillus rhamnosus GG (LGG) in ADHD: Children and adolescents report better health-related quality of life[J]. Front Psychiatry, 2020,11:181.
[26] Park S, Kim BN, Kim JW, et al. Protective effect of breastfeeding with regard to children's behavioral and cognitive problems[J]. Nutr J,2014,13(1):111.
[27] Konikowska K, Regulska-Ilow B, Rozanska D. The influence of components of diet on the symptoms of ADHD in children[J]. Rocz Panstw Zakl Hig,2012,63(2):127-134.
[28] Checa-Ros A, Jerez-Calero A, Molina-Carballo A, et al. Current evidence on the role of the gut microbiome in ADHD pathophysiology and therapeutic implications[J]. Nutrients,2021,13(1):249.
[29] Duda-Chodak A, Tarko T, Satora P, et al. Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: A review[J]. Eur J Nutr, 2015,54(3):325-341.
[30] Prehn-Kristensen A, Zimmermann A, Tittmann L, et al. Reduced microbiome alpha diversity in young patients with ADHD[J]. PLoS One,2018,13(7):e200728.
[31] Jiang HY, Zhou YY, Zhou GL, et al. Gut microbiota profiles in treatment-naive children with attention deficit hyperactivity disorder[J]. Behav Brain Res,2018,347:408-413.
[32] Wan L, Ge WR, Zhang S, et al. Case-control study of the effects of gut microbiota composition on neurotransmitter metabolic pathways in children with attention deficit hyperactivity disorder[J]. Front Neurosci,2020,14:127.
[33] Szopinska-Tokov J, Dam S, Naaijen J, et al. Investigating the gut microbiota composition of individuals with attention-deficit/hyperactivity disorder and association with symptoms[J]. Microorganisms,2020,8(3):406.
[34] Wang LJ, Yang CY, Chou WJ, et al. Gut microbiota and dietary patterns in children with attention-deficit/hyperactivity disorder[J]. Eur Child Adolesc Psychiatry,2020,29(3):287-297.
[35] Aarts E, Ederveen T, Naaijen J, et al. Gut microbiome in ADHD and its relation to neural reward anticipation[J]. PLoS One,2017,12(9):e183509.
[36] Stevens AJ, Purcell RV, Darling KA, et al. Human gut microbiome changes during a 10 week randomised control trial for micronutrient supplementation in children with attention deficit hyperactivity disorder[J]. Sci Rep,2019,9(1):10128.