Abstract: 【Objective】 To investigate the pathogens and drug tolerance of newborn dacryocystitis in order to provide evidence of clinical drug use. 【Method】 From August 2009 to October 2010, 220 cases of newborn dacryocystitis were analyzed for bacterial culture and drug sensitivity tests in children's hospital of Fudan university. 【Results】 Of the 220 samples with newborn dacryocystitis, pathogens detecting rate was 91.4％(201 cases).44.7%(93 cases) strains were gram-negative, the first three kinds of isolated bacteria were escherichia col, klebsiella pneumonia and haemophilus influenza. 52.9%(110 cases) strains were gram-positive, the first three kinds of isolated bacteria were staphylococcus epidermidis, streptococcus viridans and staphylococcus aureus. 2.4%(5 cases) were epiphyte. Gram-negative bacteria were more sensitive to levofloxacin and ciprofloxacin, the sensitivity rate was 93.5% and 90.3%. Gram-positive bacteria were more sensitive to levofloxacin and tobramycin, the sensitivity rate was 91.8% and 90.0%. Both gram-negative bacteria and gram-positive bacteria's sensitivity to erythromycin were lowest. 【Conclusion】 Gram-positive bacteria's detecting rate is higher than gram-negative bacteria's of newborn dacryocystitis, both are more sensitive to the types of antibiotics of quinolones and aminoglycosides.

Key words: newborn, dacryocystitis, pathogenic bacteria, microbial sensitivity test

摘要： 【目的】 通过对新生儿泪囊炎的病原学检测,了解其致病菌分布及药物敏感性结果,指导临床合理用药。 【方法】 选取2009年8月-2010年10月在复旦大学附属儿科医院眼科门诊诊断为新生儿泪囊炎的患者。采取泪囊区挤压获取脓性分泌物,共送检标本220份,进行细菌培养及药物敏感性分析。 【结果】 新生儿泪囊炎致病菌检出率为91.4%(201例)。G^-菌93株(44.7%),检出占前三位的分别是大肠埃希菌(12.0%)、肺炎克雷伯菌(10.1%)和流感嗜血杆菌(9.6%)。G⁺菌110株(52.9%),检出占前三位的分别是表皮葡萄球菌(12.5%)、草绿色链球菌(11.1%)和金黄色葡萄球菌(9.1%)。真菌5株(2.4%)。G^-菌对左氧氟沙星和环丙沙星最为敏感,敏感率分别是93.5%和90.3%;G⁺菌对左氧氟沙星和妥布霉素最为敏感,敏感率分别是91.8%和90.0%。细菌对红霉素的敏感性均最低。 【结论】 新生儿泪囊炎患者致病菌中,G⁺菌检出率略高于G^-菌,两者均对喹诺酮类和氨基糖甙类抗生素最为敏感。

关键词: 新生儿, 泪囊炎, 致病菌, 微生物敏感性试验