Abstract: 【Objective】 To observe the changes of serum 25-(OH)D₃ in newborns in different gestation ages,to know nutritional status of the vitamin D,and study exogenous vitamin D supplements. 【Methods】 Ninety-five newborns were studied.All the newborns were divided into three groups according to gestational age:Group A had 30 newborns(GA≤33 weeks),Group B had 34 newborns(33 weeks<GA<37 weeks),Group C had 31 newborns(37 weeks≤GA<42 weeks).Serum 25-(OH)D₃ was measured within 1 d,14 d,30 d after birth. 【Results】 The mean serum 25-(OH)D₃ concentration[(35.03±9.72) nmol/ L] of A group were lower than the mean serum 25-(OH)D₃ concentration of B and C group[(41.31±11.35) nmol/L,(42.05±15.93) nmol/L] (P<0.05)1 d after birth.76.8%,53.7% and 75.8% of newborns had vitamin D deficiency (serum 25-(OH)D₃ levels ＜50 nmol/L)in 1 d,14 d and 30 d after birth. 【Conclusion】 The vitamin D deficiency of newborns is common,and the vitamin D should be supplied as early as after birth.

Key words: newborn, 25-(OH)D₃, vitamin D deficiency

摘要： 【目的】 通过动态监测不同胎龄新生儿血清25羟维生素D₃[25-(OH)D₃]水平的变化,了解不同胎龄新生儿维生素D的营养状况,探讨外源性维生素D的补充时机。【方法】 选择95例新生儿为研究对象,按胎龄分为3组:A组30例(胎龄≤33周),B组34例(33周＜胎龄＜37周),C组31例(37周≤胎龄＜42周),于生后第1天、第14天及第30天检测血清25-(OH)D₃水平。【结果】 生后第1天A组血清(25-(OH)D₃)平均浓度[(35.03±9.72) nmol/L]低于B组和C组血清(25-(OH)D₃)平均浓度[(41.31±11.35) nmol/L和(42.05±15.93) nmol/L](P＜0.05)。生后第1 、14天及第30天各有76.8%、53.7% 和75.8%的新生儿存在维生素D缺乏[25-(OH)D₃<50 nmol/L]。【结论】 新生儿普遍存在维生素D缺乏,生后应尽早补充维生素D。

关键词: 新生儿, 25-羟维生素D₃, 维生素D缺乏