Advances in the possible mechanisms of tic disorders comorbid with allergic diseases in children

doi:10.11852/zgetbjzz2023-1327

Abstract

Abstract: In the past few decades,the incidence rate of children's allergic diseases in the world has been gradually increasing worldwide,and its impact on children has exceeded the condition of allergy itself.There is evidence suggesting a correlation between allergic diseases and the different of tic disorder (TD) in children,and allergies may be an important risk factor of TD.The underlying mechanism may be related to intestinal microbiota disorders,changes in immunological characteristics,and DNA methylation.Further exploration of the relationship between allergic diseases and TD will be of great significance for the prevention and treatment of TD.

Key words: allergic diseases, tic disorder, intestinal microbiota, immunological characteristics, DNA methylation, children

摘要： 在过去的几十年中,儿童过敏性疾病在全球范围内的发病率逐年升高,其对患儿的影响已经超出了过敏本身。有证据表明儿童过敏性疾病与抽动障碍的发生发展具有相关性。并且过敏性疾病可能是抽动障碍的重要危险因素。其发生机制可能与肠道微生态紊乱、免疫学特征改变以及DNA甲基化相关。深入探讨儿童过敏性疾病和抽动障碍之间的关系,将对预防和治疗抽动障碍具有重要意义。

关键词: 过敏性疾病, 抽动障碍, 肠道微生态, 免疫学特征, DNA甲基化, 儿童

CLC Number:

ZHANG Panpan, CAO Fan, XIAO Xuwu. Advances in the possible mechanisms of tic disorders comorbid with allergic diseases in children[J]. Chinese Journal of Child Health Care, 2024, 32(12): 1333-1338.

张盼盼, 曹凡, 肖绪武. 儿童过敏性疾病并发抽动障碍机制的研究进展[J]. 中国儿童保健杂志, 2024, 32(12): 1333-1338.

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