Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children

LI Jia, ZHANG Yanchi

Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (5) : 516-520.

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (5) : 516-520. DOI: 10.11852/zgetbjzz2022-1081
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Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children

  • LI Jia, ZHANG Yanchi
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Abstract

Vitamin D and its receptors (VDR) are widely expressed in various regions of human body.VDR mediates all molecular effects of active vitamin D, and its gene polymorphisms have been linked to a variety of neurodevelopmental disease.This article reviews the association of vitamin D and VDR gene polymorphisms with childhood neurodevelopmental disorders, providing theoretical reference for early prevention, intervention and treatment in children.

Key words

vitamin D / vitamin D receptor / gene polymorphisms / neurodevelopmental disorders

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LI Jia, ZHANG Yanchi. Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children[J]. Chinese Journal of Child Health Care. 2023, 31(5): 516-520 https://doi.org/10.11852/zgetbjzz2022-1081

References

[1] 美国精神医学学会.精神障碍诊断与统计手册[M].5版.北京: 北京大学出版社, 2015.
Association American Psychological.Diagnostic and statistical manual of mental disorders,(DSM-5)[M].5th edition.Beijing: Peking University Press, 2015.(in Chinese)
[2] 白瑜, 冯自立.维生素D受体(VDR)对中枢神经系统功能作用的研究进展[J].生命科学,2018,30(7):716-722.
Bai Y, Feng ZL.Progress of vitamin D receptor in function of central nervous system[J].Chin Bull Life Sci,2018,30(7):716-722.
[3] Bojovic K, Stankovic B, Kotur N, et al.Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders[J].Nutr Neurosci, 2019, 22(1): 40-50.
[4] 杨静, 胡燕.维生素D在孤独症谱系障碍中作用机制的研究进展[J].中国儿童保健杂志,2020,28(12):1347-1350.
Yang J, Hu Y.Research progress on the mechanism of vitamin D in autism spectrum disorders[J].Chin J Child Health Care,2020,28(12):1347-1350.(in Chinese)
[5] Zhu J, Guo M, Yang T, et al.Nutritional status and symptoms in preschool children with autism spectrum disorder: A two-center comparative study in Chongqing and Hainan province, China[J].Front Pediatr, 2020, 8(9): 469-480.
[6] Şengenç E, Kıykım E, Saltik S.Vitamin D levels in children and adolescents with autism[J].J Int Med Res, 2020, 48(7): 1-9.
[7] Chen L, Shi XJ, Liu H, et al.Oxidative stress marker aberrations in children with autism spectrum disorder: A systematic review and meta-analysis of 87 studies (n=9 109)[J].Transl Psychiatry, 2021, 11(1): 15-25.
[8] Li B, Xu Y, Zhang X, et al.The effect of vitamin D supplementation in treatment of children with autism spectrum disorder: A systematic review and Meta-analysis of randomized controlled trials[J].Nutr Neurosci, 2022, 25(4): 835-845.
[9] 程爽, 熊振芳, 蔡艺, 等.维生素D治疗孤独症谱系障碍患儿疗效及安全性的Meta分析[J].药物流行病学杂志,2021,30(12):801-805,826.
Cheng S, Xiong ZF, Cai Y, et al.Meta-analysis on the efficacy and safety of vitamin D therapy on children with autism spectrum disorder[J].Chin J Pharmacoepidemiol,2021,30(12):801-805,826.(in Chinese)
[10] Coşkun S, Şimşek Ş, Camkurt MA, et al.Association of polymorphisms in the vitamin D receptor gene and serum 25-hydroxyvitamin D levels in children with autism spectrum disorder[J].Gene, 2016, 588(2): 109-114.
[11] Guerini FR, Bolognesi E, Chiappedi M, et al.Vitamin D receptor polymorphisms associated with autism spectrum disorder[J].Autism Res, 2020, 13(5): 680-690.
[12] Cieslinska A, Kostyra E, Chwala B, et al.Vitamin D receptor gene polymorphisms associated with childhood autism[J].Brain Sci, 2017, 7(9): 115-127.
[13] Zhang ZY, Li SF, Yu LF, et al.Polymorphisms in vitamin D receptor genes in association with childhood autism spectrum disorder[J].Dis Markers, 2018, 49(10): 9481-9488.
[14] Mobasheri L, Moossavi SZ, Esmaeili A, et al.Association between vitamin D receptor gene FokⅠ and TaqⅠ variants with autism spectrum disorder predisposition in Iranian population[J].Gene, 2020, 723(1): 144133-144138.
[15] Bozdogan ST, Kutuk MO, Tufan E, et al.No association between polymorphisms of vitamin D andoxytocin receptor genes and autistic spectrum disorder in a aample of Turkish children[J].Clin Psychopharmacol Neurosci, 2018, 16(4): 415-421.
[16] Yang HC, Wu XP.The correlation between vitamin D receptor (VDR) gene polymorphisms and autism: A meta-analysis[J].J Mol Neurosci, 2020, 70(2): 260-268.
[17] Coskunpinar E, Kose T, Demirayak PA, et al.Investigation of VDR gene polymorphisms in twins with autism spectrum disorder[J].Res Autism Spectr Disord, 2021, 82(4): 101737-101746.
[18] Usategui-Martín R, Luis-Román D, Fernández-Gómez JM, et al.Vitamin D receptor (VDR) gene polymorphisms modify the response to vitamin D supplementation: A systematic review and Meta-analysis[J].Nutrients, 2022, 14(2): 360-369.
[19] Balta B, Gumus H, Bayramov R, et al.Increased vitamin D receptor gene expression and rs11568820 and rs4516035 promoter polymorphisms in autistic disorder[J].Mol Biol Rep, 2018, 45(4): 541-546.
[20] 李曼曼, 仰曙芬.维生素 D 在儿童注意力缺陷多动障碍中作用的研究进展[J].中国儿童保健杂志,2019,27(9):979-985.
Li MM, Yang SF.Research advances on the role of vitamin D in attention deficit/hyperactivity disorder children[J].Chin J Child Health Care,2019,27(9):979-985.(in Chinese)
[21] 欧阳秋星, 李万乐.儿童注意缺陷多动障碍与血清 25 羟基维生素 D 水平的关系[J].中国妇幼保健,2017,32(14):3228-3230.
Ouyang QX, Li WL.Relationship between attention deficit hyperactivity disorder and serum 25-hydroxyvitamin D level in children[J].Matern Child Health Care China,2017,32(14):3228-3230.(in Chinese)
[22] Khoshbakht Y, Bidaki R, Salehi-Abargouei A.Vitamin D status and attention deficit hyperactivity disorder: A systematic review and Meta-analysis of observational studies[J].Adv Nutr, 2018, 9(1): 9-20.
[23] 陈先睿, 黄建琪, 陈玲, 等.不同维生素 D 水平与注意缺陷多动障碍关系的 Meta 分析[J].中国全科医学,2020,23(35):4490-4497.
Chen XR, Huang JQ, Chen L, et al.Relationship between vitamin D level and attention deficit hyperactivity disorder:A meta-analysis[J].Chin Gen Pract,2020,23(35):4490-4497.(in Chinese)
[24] 上官莉莉, 赵亚茹.注意缺陷多动障碍患儿血清 25 羟基维生素 D 水平的检测[J].中国当代儿科杂志,2015,17(8):837-840.
Shangguan LL, Zhao YR.Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder[J].Chin J Contemp Pediatr,2015,17(8):837-840.(in Chinese)
[25] 应琴, 黄清选, 张剑英.注意缺陷多动障碍患儿血清 25(OH)D和微量元素表达水平及临床意义[J].浙江中西医结合杂志,2022,32(1):50-53.
Ying Q, Huang QX, Zhang JY.Clinical significance of serum 25(OH)D and trace elements levels in children with attention deficit hyperactivity disorder[J].J Zhejiang Integr Tradit Chin West Med,2022,32(1):50-53.(in Chinese)
[26] 沈玲, 蔡世忠, 季忆婷, 等.注意缺陷多动障碍儿童血清维生素 D 水平分析[J].右江民族医学院学报,2021,43(3):373-375.
Shen L, Cai SZ, Ji YT, et al.Analysis of serum vitamin D levels in children with attention deficit hyperactivity disorder[J].J Youjiang Med Univ Natl,2021,43(3):373-375.(in Chinese)
[27] 崔继华,凌昱,宋玉,等.注意缺陷多动障碍患儿血清25(OH)D营养水平状况分析[J].昆明医科大学学报,2020,41(1):91-95.
Cui JH, Ling Y, Song Y, et al.Plasma level of 25-hydroxyl vitamin D in children with attention deficit hyperactivity disorder[J].J Kunming Med Univ,2020,41(1):91-95.(in Chinese)
[28] Reinehr T, Langrock C, Hamelmann E, et al.25-hydroxvitamin D concentrations are not lower in children with bronchial asthma, atopic dermatitis, obesity, or attention-deficient/hyperactivity disorder than in healthy children[J].Nutr Res, 2018, 52(4): 39-47.
[29] 兰红艳, 霍言言, 吴丹, 等.注意缺陷多动障碍儿童的营养代谢水平及其与脑功能的相关性[J].中国儿童保健杂志,2022,30(1):11-14.
Lan HY, Huo YY, Wu D, et al.Nutrition and metabolism level of children with attention deficit hyperactivity disorder and its correlation with brain function[J].Chin J Child Health Care,2022,30(1):11-14.(in Chinese)
[30] Elshorbagy HH, Barseem NF, Abdelghani WE, et al.Impact of vitamin D supplementation on attention-deficit hyperactivity disorder in children[J].Ann Pharmacother, 2018, 52(7): 623-631.
[31] Nadia D, Gholamreza N, Aida G, et al.Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder[J].World J Pediatr, 2019, 15(1): 78-84.
[32] Mohammadpour N, Jazayeri S, Tehrani-Doost M, et al.Effect of vitamin D supplementation as adjunctive therapy to methylphenidate on ADHD symptoms: A randomized, double blind, placebo-controlled trial[J].Nutr Neurosci, 2018, 21(3): 202-209.
[33] Yan J, Feng JN, Craddock N, et al.Vitamin D receptor variants in 192 patients with schizophrenia and other psychiatric diseases[J].Neurosci Lett, 2005, 380(1-2): 37-41.
[34] Sahin N, Altun H, Kurutas EB, et al.Vitamin D and vitamin D receptor levels in children with attention-d-eficit/hyperactivity disorder[J].Neuropsychiatr Dis Treat, 2018, 14(1): 581-585.
[35] Ogbu D, Xia E, Sun J.Gut instincts: Vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders[J].Open Biol, 2020, 10(7): 200063-200074.
[36] 祝慧琴, 刘潘婷, 洪琴.言语诱发听性脑干反应在交流障碍儿童中的应用[J].中国儿童保健杂志,2022,30(5):517-520,539.
Zhu HQ, Liu PT, Hong Q.Application of speech-evoked auditory brainstem response in children with communication disorders[J].Chin J Child Health Care,2022,30(5):517-520,539.(in Chinese)
[37] Veena SR, Krishnaveni GV, Srinivasan K, et al.Association between maternal vitamin D status during pregnancy and offspring cognitive function during childhood and adolescence[J].Asia Pac J Clin Nutr, 2017, 26(3): 438-449.
[38] Whitehouse AJO, Holt BJ, Serralha M, et al.Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development[J].Pediatrics, 2012, 129(3): 485-493.
[39] Jia F, Shan L, Wang B, et al.Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children: Three cases report[J].Nutr Neurosci, 2019, 22(12): 863-866.
[40] Zhu P, Tong SL, Hao JH, et al.Cord blood vitamin D and neurocognitive development are nonlinearly related in toddlers[J].J Nutr, 2015, 145(6): 1232-1238.
[41] Tuovinen S, Räikkönen K, Holmlund-Suila E, et al.Effect of high-dose vs standard-dose vitamin D supple-mentation on neurodevelopment of healthy term infants: A randomized clinical trial[J].JAMA Netw Open, 2021, 4(9): e2124493.
[42] 杨晓燕, 侯成, 衣明纪.维生素 D 在儿童抽动障碍中的神经生化与免疫机制研究进展[J].中国儿童保健杂志,2021,29(8):857-860.
Yang XY, Hou C, Yi MJ.Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children[J].Chin J Child Health Care,2021,29(8):857-860.(in Chinese)
[43] 崔立华, 杜文冉, 杨笑, 等.唐山市2~5岁孤独症谱系障碍儿童体格发育及健康状况分析[J].中华疾病控制杂志,2022,26(9):1102-1107.
Cui LH, Du WR, Yang X, et al.Physical development and health status of children with autism spectrum disorder aged 2 - 5 years in Tangshan[J].Chin J Dis Control Prev,2022,26(9):1102-1107.(in Chinese)
[44] 方圆, 孔维延, 马晨欢, 等.注意缺陷多动障碍儿童过敏性疾病发生情况的调查[J].中国儿童保健杂志,2022,30(4):431-435, 440.
Fang Y, Kong WY, Ma CH, et al.Investigation on allergic diseases in children with attention deficit hyperactivity disorder[J].Chin J Child Health Care,2022,30(4):431-435, 440.(in Chinese)
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