Role of regulatory T-cells in different clinical expressions of Helicobacter pylori infection

doi:10.11852/zgetbjzz2018-26-01-13

Abstract

Abstract: Helicobacter pylori (H.pylori) colonization can induce vigorously innate and specific immune responses.However,the infection will not disappear and chronic active gastritis will continue if left untreated.It has been established that the topographical pattern of gastritis and its immune response are the main causes for the persistence of bacteria and the clinical outcome.There have been many controversies over the role of Treg cells in H.pylori infection.Treg cells can inhibit the body's immune response to Hp,thereby reducing the incidence of acute inflammation.At the same time,the response inhibition also causes long-term colonization of Hp in gastric mucosa and the persistence of chronic infection,leading to the further development of the disease.This paper reviews the role of Treg in different clinical expressions of H.Pylori infection.

Key words: Helicobacter pylor, regulatory T-cell, children, gastric cancer

摘要： 幽门螺杆菌(Hp)感染可诱导强烈的先天性免疫和特异性免疫应答。然而,如果未经治疗,Hp感染不会消失,慢性活动性胃炎将会持续进展。胃炎的局部状态及其免疫应答是细菌持续存在的主要原因和最终的临床结果。调节性T细胞在Hp感染中作用已经有许多争议,它可抑制机体对Hp的免疫应答,从而减轻急性炎症的发生,但同时也造成Hp在胃黏膜中的长期定植,从而使慢性感染持续存在,导致病变的进一步发展。现将调节性T细胞在Hp感染的不同临床表现中的作用作一综述。

关键词: 幽门螺杆菌, 调节性T细胞, 儿童, 胃癌

CLC Number:

R179

WANG Fang-fang, XIE Qing-zhi. Role of regulatory T-cells in different clinical expressions of Helicobacter pylori infection[J]. journal1, 2018, 26(1): 48-50.

王芳芳, 谢庆芝. 调节性T细胞在幽门螺杆菌感染相关疾病中的作用[J]. 中国儿童保健杂志, 2018, 26(1): 48-50.

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