Abstract: Objective To investigate the risk factors related to the induction of embryo damage with meta-analysis and to provide theoretic evidence for the exploration and prevention. Methods References related to embryo damage were retrieved and collected with case-control study.Mantel-Haensel fixed effect model and Dersimonian-Laird random effect model were used to perform meta-analysis by Review Manager 5.2. Results Thirty-seven articles which included 7 223 cases in embryo damage group and 6 689 cases in control group were synthetically and quantitatively analyzed by Meta-analysis.The factors with odds ratios and 95% confidence intervals in descending order were Chlamydia trachomatis 8.46(5.84~12.25),Mycoplasma urealytium 6.13(4.45~8.43),Chlamydia trachomatis and mycoplasma urealytium 5.90(3.7 7~9.25),radiation 4.83(3.63~6.44),smoking passively 4.27(3.76~4.85),home decoration 2.11(1.76~2.54),pregnancy anxiety 1.42 (1.25~1.59);pre-marital check-up 0.60(0.51~0.71),physical exercise 0.45(0.35~0.57).All these factors were statistically significant. Conclusion Chlamydia trachomatis,Mycoplasma urealytium,radiation and smoking passively were considered to be risk factors of embryo damage,while pre-marital check-up and physical exercise might be associated with protective factors.

Key words: embryo damage, missed abortion, risk factors, Meta-analysis

摘要： 目的 利用Meta分析方法探讨影响妇女胚胎停育的危险因素,为防治措施的制定提供理论依据。方法 通过文献检索收集有关胚胎停育病例对照研究的文献,采用随机效应模型和固定效应模型通过Review Manager 5.2软件进行综合定量分析评价。结果 纳入文献37篇,累计病例组7 223例,对照组6 689例;有统计学意义的因素及其合并OR(95%CI):沙眼衣原体8.46(5.84~12.25)、解脲支原体6.13(4.45~8.43)、沙眼衣原体与解脲支原体混合感染5.90(3.77~9.25)、电磁辐射4.83(3.63~6.44)、被动吸烟4.27(3.76~4.85)、家庭装修2.11(1.76~2.54)、妊娠焦虑1.42 (1.25~1.59);婚检0.60(0.51~0.71)、体育锻炼0.45(0.35~0.57)。结论 沙眼衣原体、解脲支原体、沙眼衣原体与解脲支原体混合感染、电磁辐射、被动吸烟、家庭装修是胚胎停育的危险因素,婚检、体育锻炼则是胚胎停育的保护性因素。

关键词: 胚胎停育, 稽留流产, 影响因素, Meta分析