Meta-analysis of effect of calcium supplementation on children's height

WU Huahong; SHU Wen; YU Chengdong; ZHANG Yaqin; WU Ting; ZONG Xinnan

doi:10.11852/zgetbjzz2024-0189

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Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (11) : 1246-1251. DOI: 10.11852/zgetbjzz2024-0189

Meta Analysis

Meta-analysis of effect of calcium supplementation on children's height

WU Huahong¹, SHU Wen¹, YU Chengdong¹, ZHANG Yaqin¹, WU Ting², ZONG Xinnan¹

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Abstract

Objective To explore the effect of calcium supplementation on children's height, in order to provide reference for scientific supplementation of calcium. Methods PubMed, the Cochrane Library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data database were searched for randomized controlled trials on the effect of calcium supplementation on children's height. Papers published from the establishment of these databases to November 6th, 2023 were extracted. Meta-analysis was conducted using RevMan 5.3 software, and the quality of the articles was assessed using the Cochrane bias assessment tool in this software. The study subjects were divided into three subgroups according to age (<6 years old, 6 - 12 years old and >12 years old) for subgroup analysis. According to whether the calcium intake reached recommended intake dose, the study subjects were also divided into three groups for subgroup analysis: "both inadequate before and after intervention", " inadequate before and adequate after ", and "adequate before to excessive after". Results A total of 12 randomized controlled trials were included in this Meta-analysis. The overall meta-analysis results showed that the difference in height increment between the calcium supplementation group and the control group was 0.21cm (95%CI: -0.09 to 0.52), but the difference was not statistically significant (P=0.17). Subgroup analysis showed that there was no statistical differences in height increment between the calcium supplementation and control group in different age groups (P>0.05). Among different calcium intake dose groups, only in the "inadequate before and adequate after" group, children in the calcium supplementation group had a significantly higher height increment than control group, with a difference of 0.48cm (95%CI: 0.09 - 0.87, P=0.02), while there was no significant difference in height increments between the calcium supplementation and control group in the other two groups (P>0.05). Conclusions For children with insufficient calcium intake, adequate calcium supplementation can promote their height growth. While for those with sufficient calcium intake, excessive calcium supplementation has no significant effect on height.

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calcium supplementation / height / children / Meta-analysis

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WU Huahong, SHU Wen, YU Chengdong, ZHANG Yaqin, WU Ting, ZONG Xinnan. Meta-analysis of effect of calcium supplementation on children's height[J]. Chinese Journal of Child Health Care. 2024, 32(11): 1246-1251 https://doi.org/10.11852/zgetbjzz2024-0189

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