Abstract: Objective To explore the effect of calcium supplementation on children's height, in order to provide reference for scientific supplementation of calcium. Methods PubMed, the Cochrane Library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data database were searched for randomized controlled trials on the effect of calcium supplementation on children's height. Papers published from the establishment of these databases to November 6th, 2023 were extracted. Meta-analysis was conducted using RevMan 5.3 software, and the quality of the articles was assessed using the Cochrane bias assessment tool in this software. The study subjects were divided into three subgroups according to age (<6 years old, 6 - 12 years old and >12 years old) for subgroup analysis. According to whether the calcium intake reached recommended intake dose, the study subjects were also divided into three groups for subgroup analysis: "both inadequate before and after intervention", " inadequate before and adequate after ", and "adequate before to excessive after". Results A total of 12 randomized controlled trials were included in this Meta-analysis. The overall meta-analysis results showed that the difference in height increment between the calcium supplementation group and the control group was 0.21cm (95%CI: -0.09 to 0.52), but the difference was not statistically significant (P=0.17). Subgroup analysis showed that there was no statistical differences in height increment between the calcium supplementation and control group in different age groups (P>0.05). Among different calcium intake dose groups, only in the "inadequate before and adequate after" group, children in the calcium supplementation group had a significantly higher height increment than control group, with a difference of 0.48cm (95%CI: 0.09 - 0.87, P=0.02), while there was no significant difference in height increments between the calcium supplementation and control group in the other two groups (P>0.05). Conclusions For children with insufficient calcium intake, adequate calcium supplementation can promote their height growth. While for those with sufficient calcium intake, excessive calcium supplementation has no significant effect on height.

Key words: calcium supplementation, height, children, Meta-analysis

摘要： 目的 探讨补钙对儿童身高增长的影响,为儿童科学补钙提供参考依据。方法 检索PubMed、The Cochrane Library、Scopus、Web of Science、中国知网和万方数据库中补钙对儿童身高增长影响的随机对照试验,限定时间为建库至2023年11月6日。采用RevMan 5.3软件进行Meta分析,使用Cochrane偏倚风险评价工具对文献进行评估。将研究对象分别根据年龄(<6岁、6~12岁及>12岁)和干预前后的钙摄入量是否达到钙推荐摄入量(“前后均未达标”、“未达标至达标”和“达标至过量”)分为3个亚组进行分析。结果 共纳入12项随机对照研究。整体Meta分析结果显示,补钙组的身高增长值与对照组相差0.21cm(95%CI:-0.09~0.52),差值无统计学意义(P=0.17)。亚组分析结果显示:从不同年龄组看,补钙组和对照组身高增长差异均无统计学意义(P>0.05);从不同钙摄入量组看,仅在“未达标至达标”组儿童中,补钙组的身高增长值较对照组高0.48cm(95%CI:0.09~0.87),差值有统计学意义(P=0.02),而其他两组儿童中补钙组与对照组的身高增长值差异均无统计学意义(P>0.05)。结论 对钙摄入不足的儿童适量补钙(达到该年龄段的推荐摄入量)可促进其身高的生长;对钙摄入不足的儿童补钙不充分(未达到该年龄段的推荐摄入量)或钙摄入充足的儿童过度补钙对身高增长无促进作用。

关键词: 补钙, 身高, 儿童, Meta分析