关键词: 高压氧, 脑性瘫痪, Meta分析

Abstract: Objective To evaluate the effectiveness and safety of the hyperbaric oxygen (HBO) for cerebral palsy (CP) and provide guidance for clinical applications. Methods From Pubmed,Embase,Cochrane library,CNKI,CBM,VIP,Wanfang databases,the randomized controlled studies of HBO for CP were included.Two individuals assessed the quality and extracted data.Statistical analysis was performed by RevMan5.2.7 software. Results A total of 10 studies with 1 111 patients were included in meta-analysis.Meta-analysis showed:HBO did not improve the motor function of children with CP (MD=-5.64,95%CI:-13.98~2.71,P=0.19),activities of daily living.It could ameliorate the muscle tension (RR=3.38,95%CI:2.05~5.58,P<0.05),and had a positive role in developmental quotient,which could improve the efficiency significantly (RR=1.31,95%CI:1.02~1.69,P=0.04) and reduce the inefficiency (RR=0.30,95%CI:0.19~0.50,P<0.001),but the original studies were poor quality with incredibility.In the process of HBO,middle ear barotraumas and earache were common. Conclusions The evidence that HBO could improve the function of the children with CP is insufficient,security also needed further study.More high quality studies in the future are necessary and needed to objective understanding.

Key words: hyperbaric oxygen, cerebral palsy, meta-analysis