关键词: 心肌酶谱, 心肌损害, 缺氧, 肺动脉高压, 新生儿

Abstract: 【Objective】 To study the changes and clinical value of the serum myocardial enzymes in neonates with hypoxic pulmonary hypertension(HPH). 【Methods】 There were totally 30 cases of neonates as HPH group and 30 cases of neonates as control group enrolled. Tests were performed on the 1^st and 7^th day after birth separately, which included the level of serum myocardial enzymes, pulmonary artery systolic pressure(PASP) by using the color Doppler echocardiography and blood gas analysis tested by the femoral arterial blood at the same time. 【Results】 1)There were significant differences(P<0.05) of the values of PaO₂, PASP between the HPH group and the control group on the 1st day, while there were no significant difference(P>0.05) on the 7th day. There was a negative relation between the PaO₂ and PASP(P<0.05)on the 1^st day in the HPH groups, but there was no relation between PaO₂ and PASP(P>0.05)on the 7^th day in the HPH group. 2)The level of serum myocardial enzymes obviously increased and had a significant difference in the HPH group between the control group(P<0.05) on the 1^st day, however, the result had no significance statistically on the 7^th day. The values of creatine kinase myocardial myoglobin isoenzyme(CK-MB) had significant difference(P<0.05) on the 1^st day in the HPH group. It had a positive relation among the level of serum creatine kinase myocardial myoglobin isoenzyme and PASP(P<0.05), but it had no relation among the level of blood serum myocardial enzymes and PASP(P>0.05)on the 7^th day between the HPH group and the control group. 【Conclusions】 Hypoxic pulmonary hypertension can result in myocardial damage in the neonates, and the level of myocardial enzymes will increase when myocardium are damaged. They are correlative with PaO₂ and PASP.With the improvement of hypoxia and decrease of PASP, the level of blood serum myocardial enzymes will also decrease. So the level of blood serum myocardial enzymes can reflect the myocardial damage in the neonatal hypoxic pulmonary hypertension, they provide an evidence for early diagnosis and treatment of the myocardial damage in the neonatal hypoxic pulmonary hypertension.

Key words: myocardial enzymes, myocardial damage, hypoxic, pulmonary hypertension, neonatal