生命早期双酚类物质暴露对儿童心脏发育影响及机制

doi:10.11852/zgetbjzz2024-0945

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (5): 533-536.DOI: 10.11852/zgetbjzz2024-0945

生命早期双酚类物质暴露对儿童心脏发育影响及机制

杨梅^1,2, 杨凡¹, 杨蓓蓓², 卢游¹

1.四川大学华西第二医院儿童保健科,四川成都 610041;
2.成都市第七人民医院儿科

收稿日期:2024-11-19 修回日期:2025-02-11 发布日期:2025-04-30 出版日期:2025-05-10
通讯作者: 杨凡,E-mail:506742295@qq.com
作者简介:杨梅(1987—),女,硕士研究生,主要研究方向为儿童保健。
基金资助:
四川省医学会科研项目(Q20016)

Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development

YANG Mei^1,2, YANG Fan¹, YANG Beibei², LU You¹

1. Pediatric Department, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China;
2. Department of Pediatrics, Chengdu Seventh People's Hospital

Received:2024-11-19 Revised:2025-02-11 Online:2025-05-10 Published:2025-04-30
Contact: YANG Fan, E-mail:506742295@qq.com

摘要/Abstract

摘要： 生命早期阶段是个体生长发育的关键时期,这一时期环境内分泌干扰物对儿童健康有着深远影响。双酚类物质(BPs),如双酚A(BPA)和双酚S(BPS),是一类广泛应用于塑料制造、食品包装和其他消费品中的化学物质。由于潜在的内分泌干扰特性,近年来BPs暴露对儿童健康的影响受到了广泛关注。心脏作为人体的重要器官,其发育过程复杂且精细,受到多种内外因素的调控。研究表明,生命早期接触BPs可能通过模拟或干扰内源性激素的作用,影响胚胎和儿童的心脏发育。本综述重在阐明BPs对发育中心脏的影响及其病理生理机制,以期为制定有效的预防干预策略提供理论依据。

关键词: 双酚类物质, 心脏发育, 内分泌干扰物, 机制

Abstract: The early stages of life are a crucial period for individual growth and development, during which exposure to environmental endocrine-disrupting chemicals can have profound impacts on children's health. Bisphenols (BPs), such as bisphenol A (BPA) and bisphenol S (BPS), are a group of chemical compounds widely used in the manufacture of plastics, food packaging, and various consumer products.Due to its potential endocrine-disrupting properties, the impact of exposure to BPs on children's health has received widespread attention in recent years. The heart, as an important organ of the human body, has a complex and delicate development process that is regulated by various internal and external factors. Studies suggest that early-life exposure to BPs in life may affect embryonic and child cardiac development by simulating or interfering with the effects of endogenous hormones. This review aims to elucidate the impact of BPs on developing hearts and their underlying pathophysiological mechanisms, so as to provide a theoretical foundation for the development of effective preventive and interventional strategies.

Key words: bisphenols, cardiac development, endocrine disruptors, mechanism

中图分类号:

R179

杨梅, 杨凡, 杨蓓蓓, 卢游. 生命早期双酚类物质暴露对儿童心脏发育影响及机制[J]. 中国儿童保健杂志, 2025, 33(5): 533-536.

YANG Mei, YANG Fan, YANG Beibei, LU You. Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development[J]. Chinese Journal of Child Health Care, 2025, 33(5): 533-536.

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生命早期双酚类物质暴露对儿童心脏发育影响及机制

Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development

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