细胞生物力学视角下的儿童肥胖研究进展

doi:10.11852/zgetbjzz2025-0303

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (10): 1086-1090.DOI: 10.11852/zgetbjzz2025-0303

细胞生物力学视角下的儿童肥胖研究进展

彭舟^1,2, 王晓雨³, 郭锡熔^1,2

1.上海市同仁医院,上海交通大学医学院附属同仁医院,虹桥国际医学研究院,上海 200336;
2.上海市同仁医院,上海交通大学医学院附属同仁医院内分泌科,上海 200336;
3.蚌埠医科大学生命科学学院

收稿日期:2025-03-27 修回日期:2025-07-14 发布日期:2025-10-11
通讯作者: 郭锡熔,E-mail:xrguo@shsmu.edu.cn
作者简介:彭舟(1988—),男,助理研究员,博士,主要研究方向为儿童肥胖的临床和基础研究。
基金资助:
国家重点研发计划 (2021YFC2701900, 2021YFC2701903);国家自然科学基金(82170869,82200951)

Research progress of pediatric obesity from the perspective of cellular biomechanics

PENG Zhou^1,2, WANG Xiaoyu³, GUO Xirong^1,2

1. Hongqiao International Medical Research Institute, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;
2. Department of Endocrinology, Tongren Hospital, ShanghaiJiao Tong University School of Medicine, Shanghai 200336, China;
3. College of Life Sciences, Bengbu Medical College

Received:2025-03-27 Revised:2025-07-14 Published:2025-10-11
Contact: GUO Xirong, E-mail: xrguo@shsmu.edu.cn

摘要/Abstract

摘要： 近年来细胞生物力学在肥胖防治中的研究逐渐受到关注。儿童肥胖是成年代谢性疾病早期关键的防治窗口,细胞生物力学可为儿童肥胖的防治提供新的可能。传统上主要聚焦于宏观层面的运动力学,而近年来的研究已进一步深入至细胞和分子水平。为了解细胞生物力学下儿童肥胖研究进展,以细胞生物力学和儿童肥胖为检索词,通过计算机系统检索PubMed、Web of Science及CNKI等数据库,检索时限为2011—2025年,纳入近五年文献率90%以上。本文通过介绍生物力学作用元件,总结饮食运动管理和遗传因素相关的细胞生物力学研究成果,并对细胞生物力学视角下儿童肥胖的未来发展进行了展望,以期为儿童肥胖的研究拓展研究思路,提供参考。

关键词: 细胞生物力学, 儿童肥胖, 细胞外基质, 机械信号转导, 肥胖防治

Abstract: In recent years, cellular biomechanics has gained increasing attention in the field of obesity prevention and management.Childhood obesity serves as a critical early intervention window for preventing adult metabolic diseases, and cellular biomechanics may offer novel strategies for addressing this issue.Traditionally, research has focused on macro-level exercise mechanics, but recent studies have delved deeper into cellular and molecular mechanisms.To explore advances in childhood obesity research from a cellular biomechanics perspective, a systematic search was conducted in PubMed, Web of Science, and CNKI databases using keywords such as cellular biomechanics and childhood obesity, covering publications from 2011 to 2025, with over 90% of the included literature from the past five years.This review introduces key biomechanical elements, summarizes findings related to dietary and exercise interventions as well as genetic factors, and discusses future directions for childhood obesity research from a cellular biomechanics standpoint.By exploring these insights, this article aims to inspire new research approaches and serve as a valuable resource for understanding pediatric obesity from a cellular biomechanic perspective.

Key words: cell biomechanics, pediatric obesity, extracellular matrix, mechanical signal transduction, prevention and treatment of obesity

中图分类号:

R174

彭舟, 王晓雨, 郭锡熔. 细胞生物力学视角下的儿童肥胖研究进展[J]. 中国儿童保健杂志, 2025, 33(10): 1086-1090.

PENG Zhou, WANG Xiaoyu, GUO Xirong. Research progress of pediatric obesity from the perspective of cellular biomechanics[J]. Chinese Journal of Child Health Care, 2025, 33(10): 1086-1090.

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细胞生物力学视角下的儿童肥胖研究进展

Research progress of pediatric obesity from the perspective of cellular biomechanics

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