物质跨物种传输与肥胖

doi:10.11852/zgetbjzz2025-0300

中国儿童保健杂志 ›› 2025, Vol. 33 ›› Issue (10): 1091-1094.DOI: 10.11852/zgetbjzz2025-0300

物质跨物种传输与肥胖

王瑞, 郭锡熔

上海市同仁医院,上海交通大学医学院附属同仁医院,虹桥国际医学研究院,上海 200336

收稿日期:2025-03-27 修回日期:2025-07-07 发布日期:2025-10-11
通讯作者: 郭锡熔,E-mail:xrguo@shsmu.edu.cn
作者简介:王瑞(1996—),男,助理研究员,博士,主要研究为代谢性疾病的精准防治。
基金资助:
国家重点研发计划(2021YFC2701900, 2021YFC2701903);国家自然科学基金(82170869)

Cross-species transmission in obesity

WANG Rui, GUO Xirong

Hongqiao International Institute of Medicine, Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336, China

Received:2025-03-27 Revised:2025-07-07 Published:2025-10-11
Contact: GUO Xirong, E-mail: xrguo@shsmu.edu.cn

摘要/Abstract

摘要： 儿童肥胖已成为21世纪全球公共卫生难题之一。饮食结构的改变不仅导致过量能量摄入,还可通过物质跨物种传输调控人体代谢,是引发儿童肥胖的关键因素。人类与微生物、植物等其他物种在共同进化期间进行频繁的物质跨物种传输,除水平基因转移外,microRNA、同工酶和代谢物可通过肠道菌群、胞外囊泡等媒介进行跨物种传输,实现对人体代谢的跨物种调控。本文对物质跨物种传输的最新进展及肥胖中跨物种传输的最新发现进行系统阐述,以期为儿童肥胖的发生机制解析和防治策略制定提供科学依据与实践指导。

关键词: 儿童肥胖, 肠道菌群, 跨物种传输, 胞外囊泡

Abstract: Childhood obesity has constituted one of the global public health challenges of the 21st century.Changes in dietary structure not only contribute to excessive energy intake, but also regulate human metabolism through cross-species transmission of signal molecules, which plays an important role in the occurrence of childhood obesity.Humans and other species, such as microorganisms and plants, have frequently engaged in cross-species transmission of signal molecules during co-evolution.In addition to horizontal gene transfer, microRNAs, isoenzymes, and metabolites could be transferred across species through the medium of gut microbiota and extracellular vesicles to achieve cross-species regulation of human metabolism.In this study, the recent progress of cross-species transmission and the latest findings of cross-species transmission in obesity are systematically elaborated, in order to provide scientific basis and practical guidance for exploring mechanism of childhood obesity occurrence and formulating prevention and treatment strategies.

Key words: childhood obesity, gut microbiota, cross-species transmission, extracellular vesicles

中图分类号:

R179

王瑞, 郭锡熔. 物质跨物种传输与肥胖[J]. 中国儿童保健杂志, 2025, 33(10): 1091-1094.

WANG Rui, GUO Xirong. Cross-species transmission in obesity[J]. Chinese Journal of Child Health Care, 2025, 33(10): 1091-1094.

参考文献

[1] Caprio S, Santoro N, Weiss R.Childhood obesity and the associated rise in cardiometabolic complications[J].Nat Metab, 2020, 2(3): 223-232.
[2] Kansra AR, Lakkunarajah S, Jay MS.Childhood and adolescent obesity: A review[J].Front Pediatr, 2021, 8: 581461.
[3] Nixon CA, Moore HJ,Douthwaite W, et al.Identifying effective behavioural models and behaviour change strategies underpinning preschool-and school-based obesity prevention interventions aimed at 4-6-year-olds: A systematic review[J].Obes Rev, 2012, 13: 106-117.
[4] Blüher M.Obesity: Global epidemiology and pathogenesis[J].Nat Rev Endocrinol, 2019, 15(5): 288-298.
[5] Derrien M, Alvarez AS, de Vos WM.The gut microbiota in the first decade of life[J].Trends Microbiol, 2019, 27(12): 997-1010.
[6] Meyerowitz EMJ S.Plants compared to animals: The broadest comparative study of development[J].Science, 2002, 295(5559): 1482-1485.
[7] Li Y,Teng Z, Zhao D.Plant-derived cross-kingdom gene regulation benefits human health[J].Trends Plant Sci, 2023, 28(6): 626-629.
[8] Delaux PM, Schornack S.Plant evolution driven by interactions with symbiotic and pathogenic microbes[J].Science, 2021, 371(6531): eaba6605.
[9] Widen SA, Bes IC,Koreshova A, et al.Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities[J].Science, 2023, 380(6652): eade0705.
[10] Zhou Z, Li X, Liu J, et al.Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses[J].Cell Res, 2014, 25(1): 39-49.
[11] Teng Y, Ren Y, Sayed M, et al.Plant-derived exosomal microRNAs shape the gut microbiota[J].Cell Host Microbe, 2018, 24(5): 637-652.
[12] Shahid S, Kim G, Johnson NR, et al.MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs[J].Nature, 2018, 553(7686): 82-85.
[13] Betti F, Ladera-Carmona MJ, Weits DA, et al.Exogenous miRNAs induce post-transcriptional gene silencing in plants[J].Nat Plants, 2021, 7(10): 1379-1388.
[14] Wang K, Zhang Z, Hang J, et al.Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target[J].Science, 2023, 381(6657): eadd5787.
[15] Liu Y,Jarman JB, Low YS, et al.A widely distributed gene cluster compensates for uricase loss in hominids[J].Cell, 2023, 186(16): 3400-3413.
[16] Zhang N, Qian Z, He J, et al.Gut bacteria of lepidopteran herbivores facilitate digestion of plant toxins[J].Proc NatlAcad Sci USA, 2024, 121(42): e2412165121.
[17] Qi Y, Ding L, Zhang S, et al.A plant immune protein enables broad antitumor response by rescuing microRNA deficiency[J].Cell, 2022, 185(11): 1888-1904.
[18] Li Y, Wang Y, Lin X, et al.Algicidal bacteria-derived membrane vesicles as shuttles mediating cross-kingdom interactions between bacteria and algae[J].Sci Adv, 2024, 10(32): eadn4526.
[19] Choi JK,Naffouje SA, Goto M, et al.Cross-talk between cancer and Pseudomonas aeruginosa mediates tumor suppression[J].Commun Biol, 2023, 6(1): 16.
[20] Rana VS,Kitsou C, Dutta S, et al.Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development[J].Science, 2023, 379(6628): eabl3837.
[21] Chen P, Liu X,Gu C, et al.A plant-derived natural photosynthetic system for improving cell anabolism[J].Nature, 2022, 612(7940): 546-554.
[22] Cani PD, Van Hul M.Gut microbiota in overweight and obesity: Crosstalk with adipose tissue[J].Nat Rev Gastroenterol Hepatol, 2023, 21(3): 164-183.
[23] Wu C, Yang F,Zhong H, et al.Obesity-enriched gut microbe degrades myo-inositol and promotes lipid absorption[J].Cell Host Microbe, 2024, 32(8): 1301-1314.
[24] Takeuchi T,Kameyama K, Miyauchi E, et al.Fatty acid overproduction by gut commensal microbiota exacerbates obesity[J].Cell Metab, 2023, 35(2): 361-375.
[25] Fan Y, Qin M, Zhu J, et al.MicroRNA sensing and regulating microbiota-host crosstalk via diet motivation[J].Crit Rev Food Sci Nutr, 2022, 64(13): 4116-4133.
[26] Rodrigues RR,Gurung M, Li Z, et al.Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes[J].Nat Commun, 2021, 12(1): 101.
[27] Rocha BS,Laranjinha J.Nitrate from diet might fuel gut microbiota metabolism: Minding the gap between redox signaling and inter-kingdom communication[J].Free Radic Biol Med, 2020, 149: 37-43.
[28] Zhang L,Hou D, Chen X, et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: Evidence of cross-kingdom regulation by microRNA[J].Cell Res, 2011, 22(1): 107-126.
[29] Aquilano K, Ceci V, Gismondi A, et al.Adipocyte metabolism is improved by TNF receptor-targeting small RNAs identified from dried nuts[J].Commun Biol, 2019, 2(1): 317.
[30] Zhang JY, Ren CQ, Cao YN, et al.Role of MicroRNAs in dietary interventions for obesity and obesity-related diseases[J].JAgric Food Chem, 2023, 71(40): 14396-14412.
[31] Xu D, Zhou S, Liu Y, et al.Complement in breast milk modifies offspring gut microbiota to promote infant health[J].Cell, 2024, 187(3): 750-763.
[32] Yang Z, Yang M,Deehan EC, et al.Dietary fiber for the prevention of childhood obesity: A focus on the involvement of the gut microbiota[J].Gut Microbes, 2024, 16(1): 2387796.
[33] Forbes JD, Azad MB,Vehling L, et al.Association of exposure to formula in the hospital and subsequent infant feeding practices with gut microbiota and risk of overweight in the first year of life[J].JAMA Pediatr, 2018, 172(7): e181161.
[34] Woith E, Fuhrmann G, Melzig MF.Extracellular vesicles—connecting kingdoms[J].Int J Mol Sci, 2019, 20(22): 5695.

物质跨物种传输与肥胖

Cross-species transmission in obesity

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