目的 了解沈阳地区0～3岁婴幼儿维生素D(VitD)营养状况与其性别、年龄以及季节的关系,为本地区婴幼儿合理进行VitD的补充提供科学依据。方法 对沈阳市妇婴医院儿童保健门诊体检的0～3岁婴幼儿,采用化学发光法进行血清25(OH)D水平检测。结果 2 381例婴幼儿25(OH)D总体平均水平为(36.73±18.75)ng/ml,其中25(OH)D水平严重缺乏组8例(0.34%)、缺乏组174例(7.31%)、不足组149例(6.55%)、正常组2 026例(85.09%)、过量组24例(1.01%);不同性别间血清25(OH)D水平差异无统计学意义(P＞0.05);0～1岁婴儿组血清25(OH)D水平低于1～3岁幼儿组,两组差异有统计学意义(P＜0.05);不同季节婴幼儿血清25(OH)D水平冬季最高,春季最低。结论 沈阳地区0～3岁婴幼儿VitD的总体营养状况较好,但仍存在VitD缺乏及过量现象。应注重科学合理补充VitD,避免出现VitD不足、过量及中毒情况。

Objective To investigate the levels of vitamin D in the young children aged 0～3 years old and relationship with genders,ages and seasons. Method The serum levels of 25(OH)D in 2 381 children aged 0～3 years old were detected by electrochemiluminescence. Results Among 2 381 cases,the serum levels of 25(OH)D were (36.73±18.75)ng/ml,in which 8 cases(0.34%) were severe deficiency; 174 cases(7.31%) were deficiency;149 cases(6.55%) were insufficiency;2 026 cases(85.09%) were sufficiency; 24 cases(1.01%) were excess.There was no statistical difference between gender groups(P＞0.05).The serum 25(OH)D levels in the infants aged 0~1 year old were much lower than those of the children aged 1～3 years old group.There was statistical difference between 0~1 year old group and 1~3 years old group (P＜0.05).The serum 25(OH)D levels reached the highest in winter and the lowest in spring. Conclusions The level of serum 25(OH)D is great in the children aged 0～3 years old in Shenyang area.Supplementation of vitamin D should pay attention to scientific and reasonable,avoid VitD deficiency or excess,and even intoxication.