中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (6): 550-552.

• 临床研究与分析 • 上一篇    下一篇

宝鸡地区小儿急性下呼吸道感染病毒和肺炎支原体病原学的多中心研究分析

魏升云1,汤淑斌2,李武军3,刘宁霞4,李文军5,梅桂巧1   

  1. 1 宝鸡市人民医院,陕西 宝鸡 721000;
    2 宝鸡市妇幼保健院儿童医院儿科,陕西 宝鸡 721099;
    3 宝鸡市中医医院儿科,陕西 宝鸡 721001;
    4 宝鸡市陈仓中医医院儿科,陕西 宝鸡 721300;
    5 宝鸡市中心医院儿科,陕西 宝鸡 721008
  • 收稿日期:2011-12-15 发布日期:2012-06-06 出版日期:2012-06-06
  • 作者简介:魏升云(1963-),男,陕西人,主任医师,本科学历,主要研究方向为感染和免疫性疾病

Multi-center research and analysis of children with acute of lower respiratory tract infection and pneumonia,mycoplasma etiology in Baoji

WEI Sheng-yun1,TANG Shu-bin2,LI Wu-jun3,LIU Ning-xia4,LI Wen-jun5,MEI Gui-qiao1   

  1. 1 Baoji Municipal People's Hospital,Baoji,Shaanxi 721000,China;
    2 Department of Pediatric,Maternal and Child Health Hospital of Baoji City,Children's Hospital,Baoji,Shaanxi 721099,China;
    3 Departmen of Pediatric,Baoji City Chinese Medicine Hospital,Baoji,Shaanxi 721001,China;
    4 Departmen of Pediatric,the Baoji Chencang Chinese Medicine Hospital,Baoji,Shaanxi 721300,China;
    5 Departmen of Pediatric,Baoji Central Hospital,Baoji,Shaanxi 721008,China
  • Received:2011-12-15 Online:2012-06-06 Published:2012-06-06

摘要: 【目的】 了解病毒和肺炎支原体病原在宝鸡地区小儿急性下呼吸道感染(acute lower respiratory infections,ALRI)患儿中的构成特点。 【方法】 收集宝鸡市5家医院2010年8月-2011年7月ALRI住院小儿7 979例的病毒和肺炎支原体病原学检测结果进行汇总分析。 【结果】 小儿ALRI患儿血清7种急性病毒抗体IgM总阳性率为32.7%;阳性率由高到低依次为:EB病毒抗衣壳抗原抗体IgM 7.6%,柯萨奇病毒抗体IgM 7.2%,巨细胞病毒抗体IgM 5.5%,埃可病毒抗体IgM 5.1%,副流感病毒抗体IgM 4.1%,腺病毒抗体IgM 2%,呼吸道合胞病毒抗体IgM 1.2%。肺炎支原体抗体IgM阳性率12.6%。下呼吸道分泌物病原核酸(PCR-荧光探针法)检测阳性率结果为:EB病毒DNA 24.4%,肠道病毒(普通型)RNA 10.7%,呼吸道合胞病毒RNA 4.3%,柯萨奇病毒A 16 3.8%;肺炎支原体核酸定量阳性率为11.7%。 临床最常见的混合感染是EBV和MP混合感染。 【结论】 小儿ALRI病原学分布存在人群、地区和季节、年份等的差异性,病毒和肺炎支原体是宝鸡地区小儿ALRI的重要病原,病毒以EBV为主。应开展多方法、多病原的联合检测。

关键词: 呼吸道感染, 病毒, 肺炎支原体, 流行病学

Abstract: 【Objective】 To understand of the compositional characteristics the pathogenic virus and Mycoplasma pneumoniae in acute lower respiratory infections (ALRI) children in Baoji. 【Method】 From five hospitals in Baoji City,August 2010-July 2011,7 979 cases of ALRI were collected in children hospitalized with virus and Mycoplasma pneumoniae pathogen test results for meta-analysis. 【Results】 The 7 kinds of serum acute virus IgM antibody positive rate was 32.7% in ALRI children;The positive rate were:EB virus capsid antigen antibody anti-IgM 7.6%,coxsackie virus antibody IgM 7.2%,CMV antibody IgM 5.5%,echovirus antibody IgM 5.1%,parainfluenza virus antibody IgM 4.1%,adenovirus antibody IgM 2%,respiratory syncytial virus antibody IgM 1.2%,mycoplasma pneumoniae antibody IgM positive rate 12.6%.The pathogenic nucleic acid (PCR-fluorescent probe) positive rate of lower respiratory tract secretions were:EB virus DNA 24.4%,enteric virus(ordinary type) RNA 10.7%,RSV RNA 4.3%,Coxsackie virus A16 3.8%;Mycoplasma pneumoniae nucleic acid quantitation positive rate was 11.7%.The most common clinical EBV mixed infection was with MP. 【Conclusions】 The etiology of ALRI in children shows differences in the distribution of population,area and season,year,etc.EBV and Mycoplasma pneumoniae in children with ALRI in Baoji were important pathogen.Multi-method,multi-joint detection of pathogens should be carried out.

Key words: respiratory tract infection, virus, mycoplasma pneumoniae, epidemiology

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