儿童MP-IgG与脂质代谢水平的相关性

颜桑桑; 张静霞; 徐美妹; 王桂芝; 朱棠; 韩丽红

doi:10.11852/zgetbjzz2022-0606

PDF(662 KB)

中国儿童保健杂志 ›› 2023, Vol. 31 ›› Issue (8) : 904-908. DOI: 10.11852/zgetbjzz2022-0606

经验交流

儿童MP-IgG与脂质代谢水平的相关性

颜桑桑¹, 张静霞¹, 徐美妹², 王桂芝³, 朱棠¹, 韩丽红¹

作者信息 +

Relationship between MP-IgG and lipid metabolism in children

YAN Sangsang¹, ZHANG Jingxia¹, XU Meimei², WANG Guizhi³, ZHU Tang¹, HAN Lihong¹

Author information +

文章历史 +

摘要

目的分析儿童肺炎支原体(MP)感染与高脂血症之间的关系,为儿童MP感染的防治提供更好的指导方案。方法收集蒲田学院附属儿科门诊2020年10月—2021年1月期间472名常规体检儿童的血清标本,对MP-IgG和脂质代谢指标[甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)]分别进行检测。结果 MP-IgG阳性组TC、LDL-C水平均高于MP-IgG阴性组(Z=-2.746、-2.510,P<0.05)。MP-IgG阳性组的高TC血症比例大于MP-IgG阴性组(χ²=5.984,P=0.014)。MP-IgG等级与TC等级、LDL-C等级之间均存在统计学上的线性趋势(χ²=12.704、9.731,P<0.05),即剂量反应关系。Spearman相关性检验和Kendall'tau b 相关性检验均显示 MP-IgG与TC、LDL-C 呈正相关(P＜0.05)。多分类Logistic回归分析结果表明,高TC血症可能是影响儿童MP感染的重要因素,高TC血症儿童出现MP-IgG强阳性的概率是TC正常儿童的2.865倍(95%CI:1.202~6.832)。结论儿童MP感染与高脂血症存在相关性,适当降低TC水平可能有利于防治儿童MP感染。

Abstract

Objective To investigate the relationship between Mycoplasma pneumonia (MP) infection and hyperlipidemia in children, in order to provide better guidance for the prevention and treatment of MP infection in children. Methods Serum specimens were collected from 472 children who took routine physical examinations in pediatric outpatient clinic from October 2020 to January 2021.MP-IgG and lipid metabolism indicators, including triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (ApoA), apolipoprotein Protein B (ApoB), was detected separately. Results The levels of TC and LDL-C in theMP-IgG positivegroup were higher than those in the MP-IgG negative group (Z=-2.746,-2.510, P＜0.05).The proportion of hypercholesterolemia in the MP-IgG positive group was significantly higher than that in theMP-IgG negative group (χ²=5.984, P=0.014).There was a statistically linear trend, also named a dose-response relationship, between MP-IgG grades and TC grades/LDL-C grades (χ²=12.704, 9.731, P＜0.05).Both Spearman correlation test and Kendall'tau b correlation test showed that MP-IgG was positively correlated with TC and LDL-C(P<0.05).Multi-class Logistic regression analysis showed that hypercholesterolemia may be an important factor affecting MP infection in children.The probability of MP-IgG positive in children with hypercholesterolemia was 2.865(95%CI:1.202 - 6.832) times that in children with normal TC. Conclusions There is a correlation between MP infection in children and hyperlipidemia.Appropriately reduction in cholesterol level may be beneficial to prevent and treat MP infection in children.

导出引用

颜桑桑, 张静霞, 徐美妹, 王桂芝, 朱棠, 韩丽红. 儿童MP-IgG与脂质代谢水平的相关性[J]. 中国儿童保健杂志. 2023, 31(8): 904-908 https://doi.org/10.11852/zgetbjzz2022-0606

YAN Sangsang, ZHANG Jingxia, XU Meimei, WANG Guizhi, ZHU Tang, HAN Lihong. Relationship between MP-IgG and lipid metabolism in children[J]. Chinese Journal of Child Health Care. 2023, 31(8): 904-908 https://doi.org/10.11852/zgetbjzz2022-0606

中图分类号： R725.6 R725.8

参考文献

[1] 许东风,赵登峰,杨东明.肺炎支原体及流感病毒致患者呼吸道感染流行病学特征分析[J].中国病原生物学杂志,2018,13(11):1261-1264.
Xu DF,Zhao DF,Yang DM.Epidemiological analysis of respiratory infections caused by Mycoplasma pneumoniae and influenza virus[J].J Parthog Bio,2018,13(11):1261-1264.(in Chinese)
[2] Cho YJ,Han MS, Kim WS,et al.Correlation between chest radiographic findings and clinical features in hospitalized children with Mycoplasma pneumoniae pneumonia[J].PLoS One, 2019,14(8):e0219463.
[3] Kutty PK, Jain S, Taylor TH,et al.Mycoplasma pneumoniae among children hospitalized with community-acquired pneumonia[J].Clin Infect Dis, 2019,68(1):5-12.
[4] Rao H, Ericson JE, O'Hara C.Mycoplasma pneumoniae presenting with pericardial tamponade[J].Clin Pediatr(Phila), 2020,59(2):198-200.
[5] 高磊,高岭.南京地区儿童肺炎支原体感染现状分析及检测方法学比较[J].检验医学与临床,2020,17(5):633-639.
Gao L,Gao L.Analysis of current situation of Mycoplasma pneumoniae infection in children in Nanjing area and comparison of detection methods[J].Lab Med Clin,2020,17(5):633-639.(in Chinese)
[6] Groot RCAD, Sauteur PMM, Unger WWJ,et al.Things that could be Mycoplasma pneumoniae[J].J Infect, 2017,74(1):95-100.
[7] Gordon O, Oster Y, Michael-Gayego A,et al.The clinical presentation of pediatric Mycoplasma pneumoniae infections-a single center cohort[J].The Pediatr Infect Dis J, 2019,38(7):698-705.
[8] 肖培,程红,郁兆仓,等.基于体脂肪的肥胖评估指标在学龄儿童持续性血脂异常筛查中的应用[J].中华流行病学杂志,2020, 41(12):2066-2071.
Xiao P,Cheng H,Yu ZC,et al.Application of obesity indicators based on body fat in the screening of persistent dyslipidemia among school-aged children[J].Chin J Epidemiol,2020, 41(12):2066-2071.(in Chinese)
[9] 范奕,陈婷,程慧健,等.江西省6～17岁儿童青少年血脂水平[J].中国学校卫生,2021,42(5):772-775.
Fan Y,Chen T,Cheng HJ,et al.Levels of blood lipid among children and adolescents aged 6-17 years in Jiangxi Province[J].Chin J Sch Health,2021,42(5):772-775.(in Chinese)
[10] 丁文清,董虹孛,米杰.中国儿童青少年血脂异常流行现状Meta分析[J].中华流行病学杂志,2015,36(1):71-77.
Ding WQ,Dong HB,Mi J.Prevalence of dyslipidemia in Chinese children and adolescents:A Meta-analysis[J].Chin J Epidemiol,2015,36(1):71-77.(in Chinese)
[11] 施风兰.儿童青少年血糖、血脂异常流行现状及影响因素概述[J].中国妇幼保健,2017,32(10):2266-2270.
Shi FL.Overview of the epidemic status and influencing factors of glycaemia and dyslipidemia in children and adolescents[J].Matern Child Health Care China,2017,32(10):2266-2270.(in Chinese)
[12] 王明夏,贾丽红,翟玲玲,等.肥胖儿童脂肪组织内质网应激促动脉粥样硬化研究进展[J].中国医药导报,2018,15(32):24-27.
Wang MX,Jia LH,Zai LL,et al.Research progress on atherosclerosis promoted by endoplasmic reticulum stress of adipose tissue in children with obesity[J].China Med Her,2018,15(32):24-27.(in Chinese)
[13] 胡童鑫,李卫芹,乔毅娟,等.天津市学龄前儿童血脂现状分析[J].中国公共卫生,2022,38(1):25-28.
Hu TX,Li WQ,Qiao YJ,et al.Serum lipid profile and its associates in preschool children in Tianjin city[J].Chin J Public Health,2022,38(1):25-28.(in Chinese)
[14] 孔路科,刘婷婷.肺炎支原体感染与高密度脂蛋白代谢的研究进展[J].中国基层医药,2020,27(7):892-896.
Kong LK,Liu TT.Research progress on mycoplasma pneumoniae infection and high-density lipoprotein metabolism[J].Chin J Primary Med Pharm,2020,27(7):892-896.(in Chinese)
[15] 黎西,林超群,谢健敏,等.血脂检测在细菌性肺炎与支原体肺炎鉴别诊断中的作用[J].检验医学与临床,2011,8(22):2697-2700.
Li X,Lin CQ,Xie JM,et al.The effect of blood lipid test in the diagnosis of bacterial pneumonia and mycoplasma pneumonia[J].Lab Med Clin,2011,8(22):2697-2700.(in Chinese)
[16] Higuchi ML, Sambiase N, Palomino S,et al.Detection of Mycoplasma pneumoniae and chlamydia pneumoniae in ruptured atherosclerotic plaques[J].Braz J Med Biol Res, 2000,33(9):1023-1026.
[17] 王政和,邹志勇,阳益德,等.2012年中国7省份6～17岁儿童青少年血脂异常流行情况及相关因素分析[J].中华预防医学杂志,2018,52(8):798-801.
Wang ZH,Zou ZY,Yang YD,et al.Analysis of dyslipidemia prevalence and related factors among children aged 6 to 17 years in 7 provinces of China in 2012[J].Chin J Prev Med,2018,52(8):798-801.(in Chinese)
[18] 袁炜华,邓婷,冯月平.儿童呼吸道感染中肺炎支原体IgM抗体的检测结果及临床意义分析[J].中国实用医药,2021,16(4):56-58.
Yuan WH,Deng T,Feng YP.Detection results and clinical significance analysis of IgM antibody to M plasma pneumoniae in pediatric respiratory infection[J].Chin Prac Med,2021,16(4):56-58.(in Chinese)
[19] Kim JH, Kim JY, Yoo CH,et al.Macrolide resistance and its impacts on M.Pneumoniae pneumonia in children:Comparison of two recent epidemics in Korea[J].Allergy Asthma Immunol Res, 2017,9(4):340-346.
[20] 钱前.苏州地区2006-2014年住院儿童肺炎支原体呼吸道感染的流行病学特征分析[D].苏州:苏州大学,2016.
Qian Q.Epidemiological characteristics of respiratory infections of M.pneumoniae in hospitalized children in Suzhou from 2006 to 2014[D].Suzhou: Soochow University,2016.(in Chinese)
[21] 嵇龙飞,蔡云祥,张佩,等.湖州市儿童肺炎支原体感染流行病学特征[J].预防医学,2017,29(11):1165-1169.
Ji LF,Cai YX,Zhang P,et al.Epidemiological characteristics of M.pneumoniae infection in Huzhou children[J].Prev Med,2017,29(11):1165-1169.(in Chinese)
[22] 常青,高燕敏,闫超,等.2015-2016年无锡地区儿童肺炎支原体流行基因特征分析[J].中国人兽共患病学报,2018,34(7):668-672.
Chang Q,Gao YM,Yan C,et al.Genotype analysis of Mycoplasma pneumonia in children in Wuxi,2015-2016[J].Chinese Journal of Zoonoses,2018,34(7):668-672.(in Chinese)
[23] 褚爱娟,陈捷.肺炎支原体感染与冠心病发病的相关性分析[J].中国乡村医药, 2016,23(6):55-56.
Chu AJ,Chen J.Correlation analysis between M.pneumoniae infection and CHD onset[J].Chin J Rural Med Pharma, 2016,23(6):55-56.(in Chinese)
[24] 崔丽华,孙书霞,李景书,等.成人肺炎支原体感染与高脂血症相关性的研究[J].临床和实验医学杂志,2008,7(3):5-6.
Cui LH,Sun SX,Li JS,et al.Study On relationship between mycoplasma pneumonia and hyperlipidemia in adults[J].J Clin Exp Med,2008,7(3):5-6.(in Chinese)
[25] 张长娟,段全纪,周清霞.哮喘患儿血清胆固醇水平与易感肺炎支原体的关系[J].潍坊医学院学报,2014,36(6):420-422.
Zhang CJ,Duan QJ,Zhou QX.Relationship between the cholesterol level in children with asthma and susceptibility of mycoplasma pneumoniae[J].Acta Acad Med Weifang,2014,36(6):420-422.(in Chinese)
[26] 孔路科,刘婷婷,赵书青,等.肺炎支原体肺炎患儿血清HDL-C、ApoA I水平变化及其临床意义[J].山东医药,2019,59(19):27-30.
Kong LK,Liu TT,Zhao SQ,et al.Changes in serum HDL-C and ApoA Ⅰ levels in children with Mycoplasma pneumoniae pneumonia and their clinical significance[J].Shandong Med J,2019,59(19):27-30.(in Chinese)
[27] 叶玲飞.儿童肺炎支原体感染肺外损害的分析[D].合肥:安徽医科大学,2020.
Ye LF.Analysis of extrapulmonary damage to Mycoplasma pneumoniae infection in children[D].Hefei:Anhui Medical University,2020.(in Chinese)
[28] 殷剑松,徐迪,薛菲,等.儿童肺炎支原体肺炎与血脂水平的相关性研究[J].实用临床医药杂志,2022,26(5):105-108,112.
Yin JS,Xu D,Xue F,et al.Correlation between Mycoplasma pneumoniae pneumonia and blood lipid levels in children[J].J Clin Med Pract,2022,26(5):105-108,112.(in Chinese)