关键词: 神经管缺陷, 流行病学, 监测, 动态变化

Abstract: 【Objective】 To study the variation trend in incidence of neural tube defects (NTDs) during 2002 to 2010 in Shandong Province. 【Methods】 Data were collected by hospital-based monitoring,with women of gestation of 28 weeks to seven days after birth as study subjects.And 642 282 perinates were monitored in the Provincial Birth Defect Monitoring Network in 17 regions all over the province,and 242 cases of NTDs during 2002 to 2010 were recorded and analyzed. 【Results】 Incidence of NTDs was 2.1 per 10 000 in 2010,69.1% reduction from 6.8 per 10 000 in 2002,and yearly average reduction of 13.7%.Incidence of NTDs decreased by 61.1% and 75% in rural and urban areas,respectively,and incidence of spina bifida and encephalocele fell by 70.8% and 80.0%,respectively. 【Conclusions】 Incidence of NTDs showed a falling trend in Shandong province,more decrease in rural areas than in urban areas,and incidences of spina bifida and encephalocele fell faster.Babies with NTDs were in poor birth quality,higher perinatal mortality and poor prognosis.Effective preventive measures and prenatal diagnosis should be strengthened to reduce the occurrences of neural tube defects.

Key words: neural tube defects, epidemiology, monitoring, dynamic variation